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Liver X receptor beta: Wikis


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From Wikipedia, the free encyclopedia

Nuclear receptor subfamily 1, group H, member 2

PDB rendering based on 1p8d.
Available structures
1p8d, 1pq6, 1pq9, 1pqc, 1upv, 1upw
Symbols NR1H2; UNR; LXR-b; LXRB; NER; NER-I; RIP15
External IDs OMIM600380 MGI1352463 HomoloGene21397 GeneCards: NR1H2 Gene
RNA expression pattern
PBB GE NR1H2 218215 s at tn.png
More reference expression data
Species Human Mouse
Entrez 7376 22260
Ensembl ENSG00000131408 ENSMUSG00000060601
UniProt P55055 Q8BP65
RefSeq (mRNA) NM_007121 XM_001002072
RefSeq (protein) NP_009052 XP_001002072
Location (UCSC) Chr 19:
55.57 - 55.58 Mb
Chr 7:
44.42 - 44.42 Mb
PubMed search [1] [2]

Liver X receptor beta (LXR-β) is a member of the nuclear receptor family of transcription factors. LXR-β is encoded by the NR1H2 gene (nuclear receptor subfamily 1, group H, member 2).[1]

The LX receptors (LXRs) were originally identified as orphan members of the nuclear receptor superfamily because their ligands were unknown. Like other receptors in the family, LXRs heterodimerize with retinoid X receptor (see MIM 180245) and bind to specific response elements (LXREs) characterized by direct repeats separated by 4 nucleotides. Two genes, alpha (LXRA, MIM 602423) and beta, are known to encode LXR proteins (Song et al., 1995).[supplied by OMIM][1]


Liver X receptor beta has been shown to interact with NCOA6[2] and Retinoid X receptor alpha.[3]


  1. ^ a b "Entrez Gene: NR1H2 nuclear receptor subfamily 1, group H, member 2".  
  2. ^ Lee, S K; Jung S Y, Kim Y S, Na S Y, Lee Y C, Lee J W (Feb. 2001). "Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2". Mol. Endocrinol. (United States) 15 (2): 241–54. ISSN 0888-8809. PMID 11158331.  
  3. ^ Seol, W; Choi H S, Moore D D (Jan. 1995). "Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors". Mol. Endocrinol. (UNITED STATES) 9 (1): 72–85. ISSN 0888-8809. PMID 7760852.  

Further reading

  • Song C, Hiipakka RA, Kokontis JM, Liao S (1995). "Ubiquitous receptor: structures, immunocytochemical localization, and modulation of gene activation by receptors for retinoic acids and thyroid hormones.". Ann. N. Y. Acad. Sci. 761: 38–49. doi:10.1111/j.1749-6632.1995.tb31367.x. PMID 7625741.  
  • Seol W, Choi HS, Moore DD (1995). "Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors.". Mol. Endocrinol. 9 (1): 72–85. doi:10.1210/me.9.1.72. PMID 7760852.  
  • Le Beau MM, Song C, Davis EM, et al. (1995). "Assignment of the human ubiquitous receptor gene (UNR) to 19q13.3 using fluorescence in situ hybridization.". Genomics 26 (1): 166–8. doi:10.1016/0888-7543(95)80100-Z. PMID 7782080.  
  • Shinar DM, Endo N, Rutledge SJ, et al. (1994). "NER, a new member of the gene family encoding the human steroid hormone nuclear receptor.". Gene 147 (2): 273–6. doi:10.1016/0378-1119(94)90080-9. PMID 7926814.  
  • Song C, Kokontis JM, Hiipakka RA, Liao S (1994). "Ubiquitous receptor: a receptor that modulates gene activation by retinoic acid and thyroid hormone receptors.". Proc. Natl. Acad. Sci. U.S.A. 91 (23): 10809–13. doi:10.1073/pnas.91.23.10809. PMID 7971966.  
  • Janowski BA, Grogan MJ, Jones SA, et al. (1999). "Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta.". Proc. Natl. Acad. Sci. U.S.A. 96 (1): 266–71. doi:10.1073/pnas.96.1.266. PMID 9874807.  
  • Feltkamp D, Wiebel FF, Alberti S, Gustafsson JA (1999). "Identification of a novel DNA binding site for nuclear orphan receptor OR1.". J. Biol. Chem. 274 (15): 10421–9. doi:10.1074/jbc.274.15.10421. PMID 10187832.  
  • Lee SK, Jung SY, Kim YS, et al. (2001). "Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2.". Mol. Endocrinol. 15 (2): 241–54. doi:10.1210/me.15.2.241. PMID 11158331.  
  • Whitney KD, Watson MA, Goodwin B, et al. (2001). "Liver X receptor (LXR) regulation of the LXRalpha gene in human macrophages.". J. Biol. Chem. 276 (47): 43509–15. doi:10.1074/jbc.M106155200. PMID 11546778.  
  • Whitney KD, Watson MA, Collins JL, et al. (2003). "Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system.". Mol. Endocrinol. 16 (6): 1378–85. doi:10.1210/me.16.6.1378. PMID 12040022.  
  • Brendel C, Schoonjans K, Botrugno OA, et al. (2003). "The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity.". Mol. Endocrinol. 16 (9): 2065–76. doi:10.1210/me.2001-0194. PMID 12198243.  
  • Mo J, Fang SJ, Chen W, Blobe GC (2003). "Regulation of ALK-1 signaling by the nuclear receptor LXRbeta.". J. Biol. Chem. 277 (52): 50788–94. doi:10.1074/jbc.M210376200. PMID 12393874.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Williams S, Bledsoe RK, Collins JL, et al. (2003). "X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch.". J. Biol. Chem. 278 (29): 27138–43. doi:10.1074/jbc.M302260200. PMID 12736258.  
  • Färnegårdh M, Bonn T, Sun S, et al. (2003). "The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands.". J. Biol. Chem. 278 (40): 38821–8. doi:10.1074/jbc.M304842200. PMID 12819202.  
  • Fukuchi J, Song C, Ko AL, Liao S (2004). "Transcriptional regulation of farnesyl pyrophosphate synthase by liver X receptors.". Steroids 68 (7-8): 685–91. doi:10.1016/S0039-128X(03)00100-4. PMID 12957674.  
  • Hoerer S, Schmid A, Heckel A, et al. (2004). "Crystal structure of the human liver X receptor beta ligand-binding domain in complex with a synthetic agonist.". J. Mol. Biol. 334 (5): 853–61. doi:10.1016/j.jmb.2003.10.033. PMID 14643652.  
  • Walczak R, Joseph SB, Laffitte BA, et al. (2004). "Transcription of the vascular endothelial growth factor gene in macrophages is regulated by liver X receptors.". J. Biol. Chem. 279 (11): 9905–11. doi:10.1074/jbc.M310587200. PMID 14699103.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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