The Full Wiki

Liver receptor homolog-1: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

edit
Nuclear receptor subfamily 5, group A, member 2

PDB rendering based on 1yok.
Available structures
1yok, 1yuc, 1zdu, 2a66, 2ff0
Identifiers
Symbols NR5A2; B1F; B1F2; CPF; FTF; FTZ-F1; FTZ-F1beta; LRH-1; hB1F; hB1F-2
External IDs OMIM604453 MGI1346834 HomoloGene20827 GeneCards: NR5A2 Gene
Orthologs
Species Human Mouse
Entrez 2494 26424
Ensembl ENSG00000116833 ENSMUSG00000026398
UniProt O00482 Q1WLP7
RefSeq (mRNA) NM_003822 XM_990082
RefSeq (protein) NP_003813 XP_995176
Location (UCSC) Chr 1:
198.26 - 198.41 Mb
Chr 1:
138.66 - 138.78 Mb
PubMed search [1] [2]

The liver receptor homolog-1 (LRH-1) protein is a member of the nuclear receptor family of intracellular transcription factors and is encoded by the NR5A2 gene (nuclear receptor subfamily 5, group A, member 2).[1][2]

LRH-1 plays a critical role in the regulation of development, cholesterol transport, bile acid homeostasis and steroidogenesis.[3]

Contents

Interactions

Liver receptor homolog-1 has been shown to interact with Small heterodimer partner.[4][5]

References

  1. ^ Bernier D, Thomassin H, Allard D, et al. (1993). "Functional analysis of developmentally regulated chromatin-hypersensitive domains carrying the alpha 1-fetoprotein gene promoter and the albumin/alpha 1-fetoprotein intergenic enhancer.". Mol. Cell. Biol. 13 (3): 1619–33. PMID 7680097.  
  2. ^ Galarneau L, Drouin R, Bélanger L (1998). "Assignment of the fetoprotein transcription factor gene (FTF) to human chromosome band 1q32.11 by in situ hybridization.". Cytogenet. Cell Genet. 82 (3-4): 269–70. doi:10.1159/000015116. PMID 9858833.  
  3. ^ Fayard E, Auwerx J, Schoonjans K (2004). "LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis.". Trends Cell Biol. 14 (5): 250–60. doi:10.1016/j.tcb.2004.03.008. PMID 15130581.  
  4. ^ Brendel, Carole; Schoonjans Kristina, Botrugno Oronza A, Treuter Eckardt, Auwerx Johan (Sep. 2002). "The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity". Mol. Endocrinol. (United States) 16 (9): 2065–76. ISSN 0888-8809. PMID 12198243.  
  5. ^ Lee, Yoon-Kwang; Moore David D (Jan. 2002). "Dual mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner". J. Biol. Chem. (United States) 277 (4): 2463–7. doi:10.1074/jbc.M105161200. ISSN 0021-9258. PMID 11668176.  

Further reading

  • Bernier D, Thomassin H, Allard D, et al. (1993). "Functional analysis of developmentally regulated chromatin-hypersensitive domains carrying the alpha 1-fetoprotein gene promoter and the albumin/alpha 1-fetoprotein intergenic enhancer.". Mol. Cell. Biol. 13 (3): 1619–33. PMID 7680097.  
  • Wong M, Ramayya MS, Chrousos GP, et al. (1997). "Cloning and sequence analysis of the human gene encoding steroidogenic factor 1.". J. Mol. Endocrinol. 17 (2): 139–47. doi:10.1677/jme.0.0170139. PMID 8938589.  
  • Li M, Xie YH, Kong YY, et al. (1998). "Cloning and characterization of a novel human hepatocyte transcription factor, hB1F, which binds and activates enhancer II of hepatitis B virus.". J. Biol. Chem. 273 (44): 29022–31. doi:10.1074/jbc.273.44.29022. PMID 9786908.  
  • Galarneau L, Drouin R, Bélanger L (1999). "Assignment of the fetoprotein transcription factor gene (FTF) to human chromosome band 1q32.11 by in situ hybridization.". Cytogenet. Cell Genet. 82 (3-4): 269–70. doi:10.1159/000015116. PMID 9858833.  
  • Nitta M, Ku S, Brown C, et al. (1999). "CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase gene.". Proc. Natl. Acad. Sci. U.S.A. 96 (12): 6660–5. doi:10.1073/pnas.96.12.6660. PMID 10359768.  
  • Goodwin B, Jones SA, Price RR, et al. (2000). "A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis.". Mol. Cell 6 (3): 517–26. doi:10.1016/S1097-2765(00)00051-4. PMID 11030332.  
  • Wang ZN, Bassett M, Rainey WE (2001). "Liver receptor homologue-1 is expressed in the adrenal and can regulate transcription of 11 beta-hydroxylase.". J. Mol. Endocrinol. 27 (2): 255–8. doi:10.1677/jme.0.0270255. PMID 11564608.  
  • Zhang CK, Lin W, Cai YN, et al. (2001). "Characterization of the genomic structure and tissue-specific promoter of the human nuclear receptor NR5A2 (hB1F) gene.". Gene 273 (2): 239–49. doi:10.1016/S0378-1119(01)00586-8. PMID 11595170.  
  • Lee YK, Moore DD (2002). "Dual mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner.". J. Biol. Chem. 277 (4): 2463–7. doi:10.1074/jbc.M105161200. PMID 11668176.  
  • Clyne CD, Speed CJ, Zhou J, Simpson ER (2002). "Liver receptor homologue-1 (LRH-1) regulates expression of aromatase in preadipocytes.". J. Biol. Chem. 277 (23): 20591–7. doi:10.1074/jbc.M201117200. PMID 11927588.  
  • Brendel C, Gelman L, Auwerx J (2003). "Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism.". Mol. Endocrinol. 16 (6): 1367–77. doi:10.1210/me.16.6.1367. PMID 12040021.  
  • Sirianni R, Seely JB, Attia G, et al. (2002). "Liver receptor homologue-1 is expressed in human steroidogenic tissues and activates transcription of genes encoding steroidogenic enzymes.". J. Endocrinol. 174 (3): R13–7. doi:10.1677/joe.0.174R013. PMID 12208674.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Sablin EP, Krylova IN, Fletterick RJ, Ingraham HA (2003). "Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1.". Mol. Cell 11 (6): 1575–85. doi:10.1016/S1097-2765(03)00236-3. PMID 12820970.  
  • Privalsky ML (2003). "Activation incarnate.". Dev. Cell 5 (1): 1–2. doi:10.1016/S1534-5807(03)00196-5. PMID 12852843.  
  • Fayard E, Schoonjans K, Annicotte JS, Auwerx J (2003). "Liver receptor homolog 1 controls the expression of carboxyl ester lipase.". J. Biol. Chem. 278 (37): 35725–31. doi:10.1074/jbc.M302370200. PMID 12853459.  
  • Annicotte JS, Fayard E, Swift GH, et al. (2003). "Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development.". Mol. Cell. Biol. 23 (19): 6713–24. doi:10.1128/MCB.23.19.6713-6724.2003. PMID 12972592.  
  • Peng N, Kim JW, Rainey WE, et al. (2004). "The role of the orphan nuclear receptor, liver receptor homologue-1, in the regulation of human corpus luteum 3beta-hydroxysteroid dehydrogenase type II.". J. Clin. Endocrinol. Metab. 88 (12): 6020–8. doi:10.1210/jc.2003-030880. PMID 14671206.  
  • Cai YN, Zhou Q, Kong YY, et al. (2004). "LRH-1/hB1F and HNF1 synergistically up-regulate hepatitis B virus gene transcription and DNA replication.". Cell Res. 13 (6): 451–8. doi:10.1038/sj.cr.7290187. PMID 14728801.  
  • Saxena D, Safi R, Little-Ihrig L, Zeleznik AJ (2004). "Liver receptor homolog-1 stimulates the progesterone biosynthetic pathway during follicle-stimulating hormone-induced granulosa cell differentiation.". Endocrinology 145 (8): 3821–9. doi:10.1210/en.2004-0423. PMID 15117876.  

External links

Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message