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Lomustine
Systematic (IUPAC) name
N-(2-chloroethyl)-N'-cyclohexyl- N-nitrosourea
Identifiers
CAS number 13010-47-4
ATC code L01AD02
PubChem 3950
DrugBank APRD00292
Chemical data
Formula C 9H16ClN3O2  
Mol. mass 233.695 g/mol
Synonyms 1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-urea
Pharmacokinetic data
Bioavailability  ?
Protein binding 50%
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes Oral

Lomustine (or "CCNU")(Marketed under the name CeeNU in US) is an alkylating nitrosourea compound used in chemotherapy. It is in the same family as streptozotocin. This is a highly lipid soluble drug, and thus crosses the blood brain barrier. This property makes it ideal for treating brain tumors, and is its primary use. Lomustine has a long time to nadir (the time when white blood cells reach their lowest number).

Contents

Dose

Adults: 100-150mg/m2 PO every 6 weeks (subsequent dose based on WBC) [1]

Dosage Form

10mg, 40mg, 100mg Capsules

Other

It is the "C" in the "PCV" chemotherapy regimen.

References

  1. ^ Lexi-Comp Drug Information Handbook

External links

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