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Loreclezole: Wikis

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Loreclezole
Systematic (IUPAC) name
1-[(Z)-2-chloro-2-(2,4-dichlorophenyl)vinyl]-1H-1,2,4-triazole
Identifiers
CAS number 117857-45-1
ATC code none
PubChem 3034012
Chemical data
Formula C10H6Cl3N3 
Mol. mass 274.534 g/mol
Therapeutic considerations
Pregnancy cat.  ?
Legal status

Loreclezole is a sedative and an anticonvulsant which acts as a GABA agonist. It binds allosterically to the GABAA receptor.[1] The binding site of loreclezole has been shown experimentally to be shared by valerenic acid, an extract of the root of the valerian plant.[2]

References

  1. ^ Wingrove PB, Wafford KA, Bain C, Whiting PJ (May 1994). "The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunit". Proc Natl Acad Sci USA. 91 (10): 4569–73. PMID 8183949. PMC 43827. http://www.pnas.org/cgi/pmidlookup?view=long&pmid=8183949. 
  2. ^ Khom S, Baburin I, Timin E, et al. (Jul 2007). "Valerenic acid potentiates and inhibits GABA(A) receptors: molecular mechanism and subunit specificity". Neuropharmacology 53 (1): 178–87. doi:10.1016/j.neuropharm.2007.04.018. PMID 17585957. 
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