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Lutheran antigen system is a human blood group system based upon genes on chromosome 19.

This system is a single locus system, with antigens Lua and Lub. The Lu(a) negative phenotype is very rare. Antibodies to Lutheran antigens are IgG. The genes of the Lutheran group are linked to the genes responsible for the secretion of ABH substances.

A complex blood group system having pairs of alternate antigens and amorphic genes, but also subject to a dominant independently segregating repressor.

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