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Lymphotoxin: Wikis


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lymphotoxin alpha (TNF superfamily, member 1)
Symbol LTA
Alt. symbols TNFB
Entrez 4049
HUGO 6709
OMIM 153440
RefSeq NM_000595
UniProt P01374
Other data
Locus Chr. 6 p21.3
lymphotoxin beta (TNF superfamily, member 3)
Symbol LTB
Alt. symbols TNFC
Entrez 4050
HUGO 6711
OMIM 600978
RefSeq NM_002341
UniProt Q06643
Other data
Locus Chr. 6 p21.3

Lymphotoxin (also known as tumor necrosis factor-beta) is a lymphokine cytokine.

It is a protein that is produced by "killer" CD8+ T cells that kill the virally infected cells by producing holes in the cell's cell membrane.

See also

Lymphotoxin is homologous to Tumor Necrosis Factor beta, but secreted by T-cells. It is paracrine due to the small amounts produced. The effects are similar to TNF-alpha, but TNF-beta is also important for the development of lymphoid organs.

External links



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