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Lymphotoxin beta receptor (TNFR superfamily, member 3)

Crystallographic structure of a 24-residue peptide from the lymphotoxin-B receptor bound to TRAF3.[1]
Available structures
1RF3
Identifiers
Symbols LTBR; CD18; D12S370; LT-BETA-R; TNF-R-III; TNFCR; TNFR-RP; TNFR2-RP; TNFRSF3
External IDs OMIM600979 MGI104875 HomoloGene1753 GeneCards: LTBR Gene
RNA expression pattern
PBB GE LTBR 203005 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4055 17000
Ensembl ENSG00000111321 n/a
UniProt P36941 n/a
RefSeq (mRNA) NM_002342 XM_982227
RefSeq (protein) NP_002333 XP_987321
Location (UCSC) Chr 12:
6.36 - 6.37 Mb
n/a
PubMed search [1] [2]

Lymphotoxin beta receptor is a receptor for lymphotoxin which in humans is encoded by the LTBR gene.[2][3][4]

Contents

Function

The protein encoded by this gene is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta). The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and transformed cells. Activation of the encoded protein can trigger apoptosis.[2]

Not only does the LTBR help trigger apoptosis, it can lead to the release of the cytokine interleukin 8. Overexpression of LTBR in HEK293 cells increases IL-8 promoter activity and leads to IL-8 release. LTBR is also essential for development and organization of the secondary lymphoid organs and chemokine release.[5]

Structure

The Ramachandran plots show that 64.6% of all residues were in a favored region. This structure was found using X-ray diffraction. The resolution is 3.50 angstroms. The alpha and beta angles are 90 degrees while the gamma angle is 120 degrees. These plots can be found by using the second external link at the bottom of the page.

Interactions

Lymphotoxin beta receptor has been shown to interact with Diablo homolog[6] and TRAF3.[7][8][9]

References

  1. ^PDB 1RF3; Li C, Norris PS, Ni CZ, Havert ML, Chiong EM, Tran BR, Cabezas E, Reed JC, Satterthwait AC, Ware CF, Ely KR (December 2003). "Structurally distinct recognition motifs in lymphotoxin-beta receptor and CD40 for tumor necrosis factor receptor-associated factor (TRAF)-mediated signaling". J. Biol. Chem. 278 (50): 50523–9. doi:10.1074/jbc.M309381200. PMID 14517219.  
  2. ^ a b "Entrez Gene: LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4055.  
  3. ^ Baens M, Chaffanet M, Cassiman JJ, van den Berghe H, Marynen P (April 1993). "Construction and evaluation of a hncDNA library of human 12p transcribed sequences derived from a somatic cell hybrid". Genomics 16 (1): 214–8. doi:10.1006/geno.1993.1161. PMID 8486360.  
  4. ^ Crowe PD, VanArsdale TL, Walter BN, Ware CF, Hession C, Ehrenfels B, Browning JL, Din WS, Goodwin RG, Smith CA (April 1994). "A lymphotoxin-beta-specific receptor". Science (journal) 264 (5159): 707–10. doi:10.1126/science.8171323. PMID 8171323.  
  5. ^ Chang YH, Hsieh SL, Chen MC, Lin WW (August 2002). "Lymphotoxin beta receptor induces interleukin 8 gene expression via NF-kappaB and AP-1 activation". Exp. Cell Res. 278 (2): 166–74. doi:10.1006/excr.2002.5573. PMID 12169272.  
  6. ^ Kuai, Jun; Nickbarg Elliott, Wooters Joe, Qiu Yongchang, Wang Jack, Lin Lih-Ling (Apr. 2003). "Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis". J. Biol. Chem. (United States) 278 (16): 14363–9. doi:10.1074/jbc.M208672200. ISSN 0021-9258. PMID 12571250.  
  7. ^ VanArsdale, T L; VanArsdale S L, Force W R, Walter B N, Mosialos G, Kieff E, Reed J C, Ware C F (Mar. 1997). "Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (6): 2460–5. ISSN 0027-8424. PMID 9122217.  
  8. ^ Wu, M Y; Wang P Y, Han S H, Hsieh S L (Apr. 1999). "The cytoplasmic domain of the lymphotoxin-beta receptor mediates cell death in HeLa cells". J. Biol. Chem. (UNITED STATES) 274 (17): 11868–73. ISSN 0021-9258. PMID 10207006.  
  9. ^ Marsters, S A; Ayres T M, Skubatch M, Gray C L, Rothe M, Ashkenazi A (May. 1997). "Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1". J. Biol. Chem. (UNITED STATES) 272 (22): 14029–32. ISSN 0021-9258. PMID 9162022.  

Further reading

  • Elewaut D, Ware CF (2007). "The unconventional role of LT alpha beta in T cell differentiation.". Trends Immunol. 28 (4): 169–75. doi:10.1016/j.it.2007.02.005. PMID 17336158.  
  • Browning JL, Ngam-ek A, Lawton P, et al. (1993). "Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface.". Cell 72 (6): 847–56. doi:10.1016/0092-8674(93)90574-A. PMID 7916655.  
  • Crowe PD, VanArsdale TL, Walter BN, et al. (1994). "A lymphotoxin-beta-specific receptor.". Science 264 (5159): 707–10. doi:10.1126/science.8171323. PMID 8171323.  
  • Baens M, Chaffanet M, Cassiman JJ, et al. (1993). "Construction and evaluation of a hncDNA library of human 12p transcribed sequences derived from a somatic cell hybrid.". Genomics 16 (1): 214–8. doi:10.1006/geno.1993.1161. PMID 8486360.  
  • Baens M, Aerssens J, van Zand K, et al. (1996). "Isolation and regional assignment of human chromosome 12p cDNAs.". Genomics 29 (1): 44–52. doi:10.1006/geno.1995.1213. PMID 8530100.  
  • Wang X, Bornslaeger EA, Haub O, et al. (1996). "A candidate gene for the amnionless gastrulation stage mouse mutation encodes a TRAF-related protein.". Dev. Biol. 177 (1): 274–90. doi:10.1006/dbio.1996.0162. PMID 8660894.  
  • Nakano H, Oshima H, Chung W, et al. (1996). "TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor.". J. Biol. Chem. 271 (25): 14661–4. doi:10.1074/jbc.271.25.14661. PMID 8663299.  
  • Matsumoto M, Hsieh TY, Zhu N, et al. (1997). "Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-beta receptor.". J. Virol. 71 (2): 1301–9. PMID 8995654.  
  • VanArsdale TL, VanArsdale SL, Force WR, et al. (1997). "Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB.". Proc. Natl. Acad. Sci. U.S.A. 94 (6): 2460–5. doi:10.1073/pnas.94.6.2460. PMID 9122217.  
  • Wu MY, Hsu TL, Lin WW, et al. (1997). "Serine/threonine kinase activity associated with the cytoplasmic domain of the lymphotoxin-beta receptor in HepG2 cells.". J. Biol. Chem. 272 (27): 17154–9. doi:10.1074/jbc.272.27.17154. PMID 9202035.  
  • Chen CM, You LR, Hwang LH, Lee YH (1997). "Direct interaction of hepatitis C virus core protein with the cellular lymphotoxin-beta receptor modulates the signal pathway of the lymphotoxin-beta receptor.". J. Virol. 71 (12): 9417–26. PMID 9371602.  
  • Mizushima S, Fujita M, Ishida T, et al. (1998). "Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5).". Gene 207 (2): 135–40. doi:10.1016/S0378-1119(97)00616-1. PMID 9511754.  
  • Krajewska M, Krajewski S, Zapata JM, et al. (1998). "TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues.". Am. J. Pathol. 152 (6): 1549–61. PMID 9626059.  
  • Boussaud V, Soler P, Moreau J, et al. (1999). "Expression of three members of the TNF-R family of receptors (4-1BB, lymphotoxin-beta receptor, and Fas) in human lung.". Eur. Respir. J. 12 (4): 926–31. doi:10.1183/09031936.98.12040926. PMID 9817170.  
  • Murphy M, Walter BN, Pike-Nobile L, et al. (1999). "Expression of the lymphotoxin beta receptor on follicular stromal cells in human lymphoid tissues.". Cell Death Differ. 5 (6): 497–505. doi:10.1038/sj.cdd.4400374. PMID 10200501.  
  • Wu MY, Wang PY, Han SH, Hsieh SL (1999). "The cytoplasmic domain of the lymphotoxin-beta receptor mediates cell death in HeLa cells.". J. Biol. Chem. 274 (17): 11868–73. doi:10.1074/jbc.274.17.11868. PMID 10207006.  
  • Yu KY, Kwon B, Ni J, et al. (1999). "A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis.". J. Biol. Chem. 274 (20): 13733–6. doi:10.1074/jbc.274.20.13733. PMID 10318773.  
  • Rooney IA, Butrovich KD, Glass AA, et al. (2000). "The lymphotoxin-beta receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells.". J. Biol. Chem. 275 (19): 14307–15. doi:10.1074/jbc.275.19.14307. PMID 10799510.  
  • Langeggen H, Berge KE, Johnson E, Hetland G (2003). "Human umbilical vein endothelial cells express complement receptor 1 (CD35) and complement receptor 4 (CD11c/CD18) in vitro.". Inflammation 26 (3): 103–10. doi:10.1023/A:1015585530204. PMID 12083416.  
  • Chang YH, Hsieh SL, Chen MC, Lin WW (2002). "Lymphotoxin beta receptor induces interleukin 8 gene expression via NF-kappaB and AP-1 activation.". Exp. Cell Res. 278 (2): 166–74. doi:10.1006/excr.2002.5573. PMID 12169272.  

External links

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