The Full Wiki

More info on MAFB (gene)

MAFB (gene): Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

edit
V-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
Identifiers
Symbols MAFB; KRML; MGC43127
External IDs OMIM608968 MGI104555 HomoloGene31315 GeneCards: MAFB Gene
RNA expression pattern
PBB GE MAFB 218559 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9935 16658
Ensembl ENSG00000204103 ENSMUSG00000074622
UniProt Q9Y5Q3 Q3U3C8
RefSeq (mRNA) NM_005461 NM_010658
RefSeq (protein) NP_005452 NP_034788
Location (UCSC) Chr 20:
38.75 - 38.75 Mb
Chr 2:
160.06 - 160.06 Mb
PubMed search [1] [2]

Transcription factor MafB is a protein that in humans is encoded by the MAFB gene.[1][2]

The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis. The encoded nuclear protein represses ETS1-mediated transcription of erythroid-specific genes in myeloid cells. This gene contains no introns.[2]

References

  1. ^ Wang PW, Eisenbart JD, Cordes SP, Barsh GS, Stoffel M, Le Beau MM (Nov 1999). "Human KRML (MAFB): cDNA cloning, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias". Genomics 59 (3): 275-81. doi:10.1006/geno.1999.5884. PMID 10444328.  
  2. ^ a b "Entrez Gene: MAFB v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9935.  

Further reading

  • Cordes SP, Barsh GS (1995). "The mouse segmentation gene kr encodes a novel basic domain-leucine zipper transcription factor.". Cell 79 (6): 1025–34. doi:10.1016/0092-8674(94)90033-7. PMID 8001130.  
  • Sieweke MH, Tekotte H, Frampton J, Graf T (1996). "MafB is an interaction partner and repressor of Ets-1 that inhibits erythroid differentiation.". Cell 85 (1): 49–60. doi:10.1016/S0092-8674(00)81081-8. PMID 8620536.  
  • Stoffel M, Le Beau MM, Espinosa R, et al. (1996). "A yeast artificial chromosome-based map of the region of chromosome 20 containing the diabetes-susceptibility gene, MODY1, and a myeloid leukemia related gene.". Proc. Natl. Acad. Sci. U.S.A. 93 (9): 3937–41. doi:10.1073/pnas.93.9.3937. PMID 8632993.  
  • Li R, Pei H, Watson DK, Papas TS (2000). "EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes.". Oncogene 19 (6): 745–53. doi:10.1038/sj.onc.1203385. PMID 10698492.  
  • Yamada K, Tomita H, Yoshiura K, et al. (2000). "An autosomal dominant posterior polar cataract locus maps to human chromosome 20p12-q12.". Eur. J. Hum. Genet. 8 (7): 535–9. doi:10.1038/sj.ejhg.5200485. PMID 10909854.  
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Rosenberger G, Jantke I, Gal A, Kutsche K (2003). "Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling.". Hum. Mol. Genet. 12 (2): 155–67. doi:10.1093/hmg/ddg019. PMID 12499396.  
  • Hashizume H, Hamalainen H, Sun Q, et al. (2004). "Downregulation of mafB expression in T-helper cells during early differentiation in vitro.". Scand. J. Immunol. 57 (1): 28–34. doi:10.1046/j.1365-3083.2003.01181.x. PMID 12542795.  
  • Fernández-Calotti PX, Salamone G, Gamberale R, et al. (2004). "Downregulation of mac-1 expression in monocytes by surface-bound IgG.". Scand. J. Immunol. 57 (1): 35–44. doi:10.1046/j.1365-3083.2003.01187.x. PMID 12542796.  
  • Mechta-Grigoriou F, Giudicelli F, Pujades C, et al. (2003). "c-jun regulation and function in the developing hindbrain.". Dev. Biol. 258 (2): 419–31. doi:10.1016/S0012-1606(03)00135-0. PMID 12798298.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Kim JC, Badano JL, Sibold S, et al. (2004). "The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression.". Nat. Genet. 36 (5): 462–70. doi:10.1038/ng1352. PMID 15107855.  
  • Sevinsky JR, Whalen AM, Ahn NG (2004). "Extracellular signal-regulated kinase induces the megakaryocyte GPIIb/CD41 gene through MafB/Kreisler.". Mol. Cell. Biol. 24 (10): 4534–45. doi:10.1128/MCB.24.10.4534-4545.2004. PMID 15121870.  
  • Petersen HH, Hilpert J, Jacobsen C, et al. (2004). "Low-density lipoprotein receptor-related protein interacts with MafB, a regulator of hindbrain development.". FEBS Lett. 565 (1-3): 23–7. doi:10.1016/j.febslet.2004.03.069. PMID 15135046.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Bakri Y, Sarrazin S, Mayer UP, et al. (2005). "Balance of MafB and PU.1 specifies alternative macrophage or dendritic cell fate.". Blood 105 (7): 2707–16. doi:10.1182/blood-2004-04-1448. PMID 15598817.  
  • Gemelli C, Montanari M, Tenedini E, et al. (2006). "Virally mediated MafB transduction induces the monocyte commitment of human CD34+ hematopoietic stem/progenitor cells.". Cell Death Differ. 13 (10): 1686–96. doi:10.1038/sj.cdd.4401860. PMID 16456583.  
  • Lee LC, Zhang AY, Chong AK, et al. (2006). "Expression of a novel gene, MafB, in Dupuytren's disease.". The Journal of hand surgery 31 (2): 211–8. doi:10.1016/j.jhsa.2005.09.007. PMID 16473681.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message