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V-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
Identifiers
Symbols MAFK; P18; FLJ32205; MGC71717; NFE2U
External IDs OMIM600197 MGI99951 HomoloGene1770 GeneCards: MAFK Gene
Orthologs
Species Human Mouse
Entrez 7975 17135
Ensembl ENSG00000198517 ENSMUSG00000018143
UniProt O60675 Q3U568
RefSeq (mRNA) NM_002360 NM_010757
RefSeq (protein) NP_002351 NP_034887
Location (UCSC) Chr 7:
1.54 - 1.55 Mb
Chr 5:
140.04 - 140.06 Mb
PubMed search [1] [2]

Transcription factor MafK is a protein that in humans is encoded by the MAFK gene.[1][2]

The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase (PBGD; MIM 609806) and ferrochelatase (FECH; MIM 177000). NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG (MIM 602020), or MafK) and p45 (MIM 601490). Both subunits are members of the activator protein-1 superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160). Maf homodimers suppress transcription at NFE2 sites.[supplied by OMIM][2]

References

  1. ^ Iwata T, Kogame K, Toki T, Yokoyama M, Yamamoto M, Ito E (Nov 1998). "Structure and chromosome mapping of the human small maf-genes MAFG and MAFK". Cytogenet Cell Genet 82 (1-2): 88-90. PMID 9763667.  
  2. ^ a b "Entrez Gene: MAFK v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7975.  

Further reading

  • Ney PA, Andrews NC, Jane SM, et al. (1993). "Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner.". Mol. Cell. Biol. 13 (9): 5604–12. PMID 8355703.  
  • Oyake T, Itoh K, Motohashi H, et al. (1996). "Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site.". Mol. Cell. Biol. 16 (11): 6083–95. PMID 8887638.  
  • Toki T, Itoh J, Kitazawa J, et al. (1997). "Human small Maf proteins form heterodimers with CNC family transcription factors and recognize the NF-E2 motif.". Oncogene 14 (16): 1901–10. doi:10.1038/sj.onc.1201024. PMID 9150357.  
  • Quevillon S, Robinson JC, Berthonneau E, et al. (1999). "Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein.". J. Mol. Biol. 285 (1): 183–95. doi:10.1006/jmbi.1998.2316. PMID 9878398.  
  • Kobayashi A, Ito E, Toki T, et al. (1999). "Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3.". J. Biol. Chem. 274 (10): 6443–52. doi:10.1074/jbc.274.10.6443. PMID 10037736.  
  • Nguyen T, Huang HC, Pickett CB (2000). "Transcriptional regulation of the antioxidant response element. Activation by Nrf2 and repression by MafK.". J. Biol. Chem. 275 (20): 15466–73. doi:10.1074/jbc.M000361200. PMID 10747902.  
  • Dhakshinamoorthy S, Jaiswal AK (2001). "Small maf (MafG and MafK) proteins negatively regulate antioxidant response element-mediated expression and antioxidant induction of the NAD(P)H:Quinone oxidoreductase1 gene.". J. Biol. Chem. 275 (51): 40134–41. doi:10.1074/jbc.M003531200. PMID 11013233.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.  
  • Newman JR, Keating AE (2003). "Comprehensive identification of human bZIP interactions with coiled-coil arrays.". Science 300 (5628): 2097–101. doi:10.1126/science.1084648. PMID 12805554.  
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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