The Full Wiki

More info on MAP3K11

MAP3K11: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

edit
Mitogen-activated protein kinase kinase kinase 11
Identifiers
Symbols MAP3K11; MGC17114; MLK-3; MLK3; PTK1; SPRK
External IDs OMIM600050 MGI1346880 HomoloGene37618 GeneCards: MAP3K11 Gene
RNA expression pattern
PBB GE MAP3K11 203652 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4296 26403
Ensembl ENSG00000173327 n/a
UniProt Q16584 n/a
RefSeq (mRNA) NM_002419 XM_979737
RefSeq (protein) NP_002410 XP_984831
Location (UCSC) Chr 11:
65.12 - 65.14 Mb
n/a
PubMed search [1] [2]

Mitogen-activated protein kinase kinase kinase 11 is an enzyme that in humans is encoded by the MAP3K11 gene.[1][2]

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42.[3]

Interactions

MAP3K11 has been shown to interact with MAPK8IP1,[4] CDC42,[5][6] SH3RF1,[7] MAPK8IP2[4] and AKT1.[8]

References

  1. ^ Smith CM, Ma NS, Nowak NJ, Shows TB, Gerhard DS (Oct 1997). "A 3-Mb contig from D11S987 to MLK3, a gene-rich region in 11q13". Genome Res 7 (8): 835–42. PMID 9267807.  
  2. ^ Ing YL, Leung IW, Heng HH, Tsui LC, Lassam NJ (Jun 1994). "MLK-3: identification of a widely-expressed protein kinase bearing an SH3 domain and a leucine zipper-basic region domain". Oncogene 9 (6): 1745–50. PMID 8183572.  
  3. ^ "Entrez Gene: MAP3K11 mitogen-activated protein kinase kinase kinase 11". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4296.  
  4. ^ a b Yasuda, J; Whitmarsh A J, Cavanagh J, Sharma M, Davis R J (Oct. 1999). "The JIP group of mitogen-activated protein kinase scaffold proteins". Mol. Cell. Biol. (UNITED STATES) 19 (10): 7245–54. ISSN 0270-7306. PMID 10490659.  
  5. ^ Nagata, K i; Puls A, Futter C, Aspenstrom P, Schaefer E, Nakata T, Hirokawa N, Hall A (Jan. 1998). "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3". EMBO J. (ENGLAND) 17 (1): 149–58. doi:10.1093/emboj/17.1.149. ISSN 0261-4189. PMID 9427749.  
  6. ^ Böck, B C; Vacratsis P O, Qamirani E, Gallo K A (May. 2000). "Cdc42-induced activation of the mixed-lineage kinase SPRK in vivo. Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylation". J. Biol. Chem. (UNITED STATES) 275 (19): 14231–41. ISSN 0021-9258. PMID 10799501.  
  7. ^ Figueroa, Claudia; Tarras Samantha, Taylor Jennifer, Vojtek Anne B (Nov. 2003). "Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex". J. Biol. Chem. (United States) 278 (48): 47922–7. doi:10.1074/jbc.M307357200. ISSN 0021-9258. PMID 14504284.  
  8. ^ Barthwal, Manoj K; Sathyanarayana Pradeep, Kundu Chanakya N, Rana Basabi, Pradeep Anamika, Sharma Chandan, Woodgett James R, Rana Ajay (Feb. 2003). "Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival". J. Biol. Chem. (United States) 278 (6): 3897–902. doi:10.1074/jbc.M211598200. ISSN 0021-9258. PMID 12458207.  

Further reading

  • van de Bovenkamp M, Nottet HS, Pereira CF (2003). "Interactions of human immunodeficiency virus-1 proteins with neurons: possible role in the development of human immunodeficiency virus-1-associated dementia.". Eur. J. Clin. Invest. 32 (8): 619–27. doi:10.1046/j.1365-2362.2002.01029.x. PMID 12190962.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Gallo KA, Mark MR, Scadden DT, et al. (1994). "Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity.". J. Biol. Chem. 269 (21): 15092–100. PMID 8195146.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Nagata K, Puls A, Futter C, et al. (1998). "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3.". EMBO J. 17 (1): 149–58. doi:10.1093/emboj/17.1.149. PMID 9427749.  
  • Tanaka S, Hanafusa H (1998). "Guanine-nucleotide exchange protein C3G activates JNK1 by a ras-independent mechanism. JNK1 activation inhibited by kinase negative forms of MLK3 and DLK mixed lineage kinases.". J. Biol. Chem. 273 (3): 1281–4. doi:10.1074/jbc.273.3.1281. PMID 9430657.  
  • Leung IW, Lassam N (1999). "Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated protein kinase kinase kinase, MLK-3.". J. Biol. Chem. 273 (49): 32408–15. doi:10.1074/jbc.273.49.32408. PMID 9829970.  
  • Merritt SE, Mata M, Nihalani D, et al. (1999). "The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate.". J. Biol. Chem. 274 (15): 10195–202. doi:10.1074/jbc.274.15.10195. PMID 10187804.  
  • Yasuda J, Whitmarsh AJ, Cavanagh J, et al. (2000). "The JIP group of mitogen-activated protein kinase scaffold proteins.". Mol. Cell. Biol. 19 (10): 7245–54. PMID 10490659.  
  • Kelkar N, Gupta S, Dickens M, Davis RJ (2000). "Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3.". Mol. Cell. Biol. 20 (3): 1030–43. doi:10.1128/MCB.20.3.1030-1043.2000. PMID 10629060.  
  • Hehner SP, Hofmann TG, Ushmorov A, et al. (2000). "Mixed-lineage kinase 3 delivers CD3/CD28-derived signals into the IkappaB kinase complex.". Mol. Cell. Biol. 20 (7): 2556–68. doi:10.1128/MCB.20.7.2556-2568.2000. PMID 10713178.  
  • Böck BC, Vacratsis PO, Qamirani E, Gallo KA (2000). "Cdc42-induced activation of the mixed-lineage kinase SPRK in vivo. Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylation.". J. Biol. Chem. 275 (19): 14231–41. doi:10.1074/jbc.275.19.14231. PMID 10799501.  
  • Leung IW, Lassam N (2001). "The kinase activation loop is the key to mixed lineage kinase-3 activation via both autophosphorylation and hematopoietic progenitor kinase 1 phosphorylation.". J. Biol. Chem. 276 (3): 1961–7. doi:10.1074/jbc.M004092200. PMID 11053428.  
  • Svensson AC, Raudsepp T, Larsson C, et al. (2001). "Chromosomal distribution, localization and expression of the human endogenous retrovirus ERV9.". Cytogenet. Cell Genet. 92 (1-2): 89–96. doi:10.1159/000056875. PMID 11306803.  
  • Zhang H, Gallo KA (2002). "Autoinhibition of mixed lineage kinase 3 through its Src homology 3 domain.". J. Biol. Chem. 276 (49): 45598–603. doi:10.1074/jbc.M107176200. PMID 11590155.  
  • Lambert JM, Karnoub AE, Graves LM, et al. (2002). "Role of MLK3-mediated activation of p70 S6 kinase in Rac1 transformation.". J. Biol. Chem. 277 (7): 4770–7. doi:10.1074/jbc.M109379200. PMID 11713255.  
  • Chadee DN, Yuasa T, Kyriakis JM (2002). "Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2.". Mol. Cell. Biol. 22 (3): 737–49. doi:10.1128/MCB.22.3.737-749.2002. PMID 11784851.  
  • Vacratsis PO, Phinney BS, Gage DA, Gallo KA (2002). "Identification of in vivo phosphorylation sites of MLK3 by mass spectrometry and phosphopeptide mapping.". Biochemistry 41 (17): 5613–24. doi:10.1021/bi016075c. PMID 11969422.  
Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message