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Mitogen-activated protein kinase-activated protein kinase 5
External IDs OMIM606723 MGI1333110 HomoloGene69077 GeneCards: MAPKAPK5 Gene
RNA expression pattern
PBB GE MAPKAPK5 212871 at tn.png
PBB GE MAPKAPK5 gnf1h00042 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8550 17165
Ensembl ENSG00000089022 ENSMUSG00000029454
UniProt Q8IW41 Q3UV25
RefSeq (mRNA) NM_003668 XM_990515
RefSeq (protein) NP_003659 XP_995609
Location (UCSC) Chr 12:
110.79 - 110.82 Mb
Chr 5:
121.79 - 121.81 Mb
PubMed search [1] [2]

MAP kinase-activated protein kinase 5 is an enzyme that in humans is encoded by the MAPKAPK5 gene.[1][2] The protein encoded by this gene is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported.[2]


Further reading

  • de Carvalho MG, McCormack AL, Olson E, et al. (1996). "Identification of phosphorylation sites of human 85-kDa cytosolic phospholipase A2 expressed in insect cells and present in human monocytes.". J. Biol. Chem. 271 (12): 6987–97. doi:10.1074/jbc.271.12.6987. PMID 8636128.  
  • Börsch-Haubold AG, Bartoli F, Asselin J, et al. (1998). "Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells.". J. Biol. Chem. 273 (8): 4449–58. doi:10.1074/jbc.273.8.4449. PMID 9468497.  
  • Ni H, Wang XS, Diener K, Yao Z (1998). "MAPKAPK5, a novel mitogen-activated protein kinase (MAPK)-activated protein kinase, is a substrate of the extracellular-regulated kinase (ERK) and p38 kinase.". Biochem. Biophys. Res. Commun. 243 (2): 492–6. doi:10.1006/bbrc.1998.8135. PMID 9480836.  
  • Sudo T, Maruyama M, Osada H (2000). "p62 functions as a p38 MAP kinase regulator.". Biochem. Biophys. Res. Commun. 269 (2): 521–5. doi:10.1006/bbrc.2000.2333. PMID 10708586.  
  • Hefner Y, Borsch-Haubold AG, Murakami M, et al. (2001). "Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases.". J. Biol. Chem. 275 (48): 37542–51. doi:10.1074/jbc.M003395200. PMID 10978317.  
  • Zhou J, Lottenbach KR, Barenkamp SJ, et al. (2002). "Recurrent variable region gene usage and somatic mutation in the human antibody response to the capsular polysaccharide of Streptococcus pneumoniae type 23F.". Infect. Immun. 70 (8): 4083–91. doi:10.1128/IAI.70.8.4083-4091.2002. PMID 12117915.  
  • Perfetti V, Casarini S, Palladini G, et al. (2002). "Analysis of V(lambda)-J(lambda) expression in plasma cells from primary (AL) amyloidosis and normal bone marrow identifies 3r (lambdaIII) as a new amyloid-associated germline gene segment.". Blood 100 (3): 948–53. doi:10.1182/blood-2002-01-0114. PMID 12130507.  
  • Knebel A, Haydon CE, Morrice N, Cohen P (2002). "Stress-induced regulation of eukaryotic elongation factor 2 kinase by SB 203580-sensitive and -insensitive pathways.". Biochem. J. 367 (Pt 2): 525–32. doi:10.1042/BJ20020916. PMID 12171600.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • New L, Jiang Y, Han J (2004). "Regulation of PRAK subcellular location by p38 MAP kinases.". Mol. Biol. Cell 14 (6): 2603–16. doi:10.1091/mbc.E02-08-0538. PMID 12808055.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Sun P, Yoshizuka N, New L, et al. (2007). "PRAK is essential for ras-induced senescence and tumor suppression.". Cell 128 (2): 295–308. doi:10.1016/j.cell.2006.11.050. PMID 17254968.  


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