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MAS1 oncogene
Symbols MAS1; MAS; MGC119966
External IDs OMIM165180 MGI96918 HomoloGene1782 IUPHAR: MAS1 GeneCards: MAS1 Gene
RNA expression pattern
PBB GE MAS1 208210 at tn.png
More reference expression data
Species Human Mouse
Entrez 4142 17171
Ensembl ENSG00000130368 ENSMUSG00000068037
UniProt P04201 Q0VB49
RefSeq (mRNA) NM_002377 XM_622557
RefSeq (protein) NP_002368 XP_622557
Location (UCSC) Chr 6:
160.25 - 160.25 Mb
Chr 17:
12.68 - 12.69 Mb
PubMed search [1] [2]

MAS proto-oncogene is a protein that in humans is encoded by the MAS1 gene.[1]

The structure of the MAS1 product indicates that it belongs to the class of receptors that are coupled to GTP-binding proteins and share a conserved structural motif, which is described as a '7-transmembrane segment' following the prediction that these hydrophobic segments form membrane-spanning alpha-helices. The MAS1 protein may be a receptor that, when activated, modulates a critical component in a growth-regulating pathway to bring about oncogenic effects.[1]

See also


Further reading

  • Hanley MR (1992). "Molecular and cell biology of angiotensin receptors.". J. Cardiovasc. Pharmacol. 18 Suppl 2: S7–13. PMID 1725048.  
  • Hanley MR, Cheung WT, Hawkins P, et al. (1990). "The mas oncogene as a neural peptide receptor: expression, regulation and mechanism of action.". Ciba Found. Symp. 150: 23–38; discussion 38–46. PMID 2197067.  
  • Rabin M, Birnbaum D, Young D, et al. (1988). "Human ros1 and mas1 oncogenes located in regions of chromosome 6 associated with tumor-specific rearrangements.". Oncogene Res. 1 (2): 169–78. PMID 3329713.  
  • Jackson TR, Blair LA, Marshall J, et al. (1988). "The mas oncogene encodes an angiotensin receptor.". Nature 335 (6189): 437–40. doi:10.1038/335437a0. PMID 3419518.  
  • Young D, Waitches G, Birchmeier C, et al. (1986). "Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains.". Cell 45 (5): 711–9. doi:10.1016/0092-8674(86)90785-3. PMID 3708691.  
  • Riesewijk AM, Schepens MT, Mariman EM, et al. (1996). "The MAS proto-oncogene is not imprinted in humans.". Genomics 35 (2): 380–2. doi:10.1006/geno.1996.0372. PMID 8661154.  
  • Xu X, Quiambao AB, Roveri L, et al. (2000). "Degeneration of cone photoreceptors induced by expression of the Mas1 protooncogene.". Exp. Neurol. 163 (1): 207–19. doi:10.1006/exnr.2000.7370. PMID 10785460.  
  • Alenina N, Baranova T, Smirnow E, et al. (2002). "Cell type-specific expression of the Mas proto-oncogene in testis.". J. Histochem. Cytochem. 50 (5): 691–6. PMID 11967280.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Santos RA, Simoes e Silva AC, Maric C, et al. (2003). "Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas.". Proc. Natl. Acad. Sci. U.S.A. 100 (14): 8258–63. doi:10.1073/pnas.1432869100. PMID 12829792.  
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Canals M, Jenkins L, Kellett E, Milligan G (2006). "Up-regulation of the angiotensin II type 1 receptor by the MAS proto-oncogene is due to constitutive activation of Gq/G11 by MAS.". J. Biol. Chem. 281 (24): 16757–67. doi:10.1074/jbc.M601121200. PMID 16611642.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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