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MAS1 oncogene: Wikis

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MAS1 oncogene
Identifiers
Symbol MAS1
Entrez 4142
HUGO 6899
OMIM 165180
RefSeq NM_002377
UniProt P04201
Other data
Locus Chr. 6 q24-q27
MAS1 oncogene-like
Identifiers
Symbol MAS1L
Entrez 116511
HUGO 13961
OMIM 607235
RefSeq NM_052967
UniProt P35410
Other data
Locus Chr. 6 p21

The MAS1 oncogene is a G protein-coupled receptor[1] which binds the angiotensin-II metabolite angiotensin-(1-7).[2][3] The MAS1 receptor when activated by binding angiotensin-(1-7) opposes many of the effects of angiotensin-II activated angiotensin receptor. Hence MAS1 receptor agonists have similar therapeutic effects as angiotensin-II receptor antagonists including lowering blood pressure.[4]

References

  1. ^ Young D, Waitches G, Birchmeier C, Fasano O, Wigler M (1986). "Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains". Cell 45 (5): 711–9. doi:10.1016/0092-8674(86)90785-3. PMID 3708691.  
  2. ^ Santos RA, Simoes e Silva AC, Maric C, Silva DM, Machado RP, de Buhr I, Heringer-Walther S, Pinheiro SV, Lopes MT, Bader M, Mendes EP, Lemos VS, Campagnole-Santos MJ, Schultheiss HP, Speth R, Walther T (2003). "Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas". Proc. Natl. Acad. Sci. U.S.A. 100 (14): 8258–63. doi:10.1073/pnas.1432869100. PMID 12829792.  
  3. ^ Santos RA, Ferreira AJ (2007). "Angiotensin-(1-7) and the renin-angiotensin system". Curr. Opin. Nephrol. Hypertens. 16 (2): 122–8. doi:10.1097/MNH.0b013e328031f362. PMID 17293687.  
  4. ^ Santos RA, Ferreira AJ (2006). "Pharmacological effects of AVE 0991, a nonpeptide angiotensin-(1-7) receptor agonist". Cardiovascular drug reviews 24 (3-4): 239–46. doi:10.1111/j.1527-3466.2006.00239.x. PMID 17214600.  

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