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MASP1 (protein): Wikis


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mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
Symbol MASP1
Alt. symbols CRARF, PRSS5
Entrez 5648
HUGO 6901
OMIM 600521
RefSeq NM_001879
UniProt P48740
Other data
Locus Chr. 3 q27-q28

Mannose-associated serine protease 1 (MASP1) is a human gene.[1][2]

The protein encoded by this gene is involved in the lectin pathway of the complement system and is responsible for cleaving C4 and C2 to form C4b2a, a C3-convertase.[3]

See also


  1. ^ Takada F, Takayama Y, Hatsuse H, Kawakami M (October 1993). "A new member of the C1s family of complement proteins found in a bactericidal factor, Ra-reactive factor, in human serum". Biochem. Biophys. Res. Commun. 196 (2): 1003–9. doi:10.1006/bbrc.1993.2349. PMID 8240317.  
  2. ^ Sato T, Endo Y, Matsushita M, Fujita T (April 1994). "Molecular characterization of a novel serine protease involved in activation of the complement system by mannose-binding protein". Int. Immunol. 6 (4): 665–9. doi:10.1093/intimm/6.4.665. PMID 8018603.  
  3. ^ Matsushita M, Thiel S, Jensenius JC, Terai I, Fujita T (1 September 2000). "Proteolytic activities of two types of mannose-binding lectin-associated serine protease". J. Immunol. 165 (5): 2637–42. PMID 10946292.  

External links



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