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MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)
Identifiers
Symbols MCM7; MCM2; CDABP0042; CDC47; P1.1-MCM3; P1CDC47; P85MCM; PNAS-146
External IDs OMIM600592 MGI1298398 HomoloGene4323 GeneCards: MCM7 Gene
RNA expression pattern
PBB GE MCM7 208795 s at tn.png
PBB GE MCM7 210983 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4176 17220
Ensembl ENSG00000166508 ENSMUSG00000029730
UniProt P33993 Q3U4T8
RefSeq (mRNA) NM_005916 NM_008568
RefSeq (protein) NP_005907 NP_032594
Location (UCSC) Chr 7:
99.53 - 99.54 Mb
Chr 5:
138.39 - 138.4 Mb
PubMed search [1] [2]

DNA replication licensing factor MCM7 is a protein that in humans is encoded by the MCM7 gene.[1]

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[2]

See also

Interactions

MCM7 has been shown to interact with Replication protein A1,[3] ORC3L,[3] Retinoblastoma protein,[4] MCM5,[3][5][6] MCM6,[7][3][5][8] ORC1L,[3] ORC2L,[3] ORC5L,[3] MCM4,[7][5][9][8] MCM3,[3][10][5][11] CDC6,[3][10] MNAT1,[12] DBF4,[3] MCM2,[7][3][13][5][8] UBE3A,[14] CDC45-related protein[3][15] and Cell division cycle 7-related protein kinase.[3]

References

  1. ^ Nakatsuru S, Sudo K, Nakamura Y (Mar 1995). "Isolation and mapping of a human gene (MCM2) encoding a product homologous to yeast proteins involved in DNA replication". Cytogenet Cell Genet 68 (3-4): 226–30. PMID 7842741.  
  2. ^ "Entrez Gene: MCM7 MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4176.  
  3. ^ a b c d e f g h i j k l m Kneissl, Margot; Pütter Vera, Szalay Aladar A, Grummt Friedrich (Mar. 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. (England) 327 (1): 111–28. ISSN 0022-2836. PMID 12614612.  
  4. ^ Sterner, J M; Dew-Knight S, Musahl C, Kornbluth S, Horowitz J M (May. 1998). "Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7". Mol. Cell. Biol. (UNITED STATES) 18 (5): 2748–57. ISSN 0270-7306. PMID 9566894.  
  5. ^ a b c d e Fujita, M; Kiyono T, Hayashi Y, Ishibashi M (Apr. 1997). "In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP". J. Biol. Chem. (UNITED STATES) 272 (16): 10928–35. ISSN 0021-9258. PMID 9099751.  
  6. ^ DaFonseca, C J; Shu F, Zhang J J (Mar. 2001). "Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma". Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (6): 3034–9. doi:10.1073/pnas.061487598. ISSN 0027-8424. PMID 11248027.  
  7. ^ a b c Yabuta, Norikazu; Kajimura Naoko, Mayanagi Kouta, Sato Michio, Gotow Takahito, Uchiyama Yasuo, Ishimi Yukio, Nojima Hiroshi (May. 2003). "Mammalian Mcm2/4/6/7 complex forms a toroidal structure". Genes Cells (England) 8 (5): 413–21. ISSN 1356-9597. PMID 12694531.  
  8. ^ a b c You, Zhiying; Ishimi Yukio, Masai Hisao, Hanaoka Fumio (Nov. 2002). "Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex". J. Biol. Chem. (United States) 277 (45): 42471–9. doi:10.1074/jbc.M205769200. ISSN 0021-9258. PMID 12207017.  
  9. ^ Ishimi, Y; Ichinose S, Omori A, Sato K, Kimura H (Sep. 1996). "Binding of human minichromosome maintenance proteins with histone H3". J. Biol. Chem. (UNITED STATES) 271 (39): 24115–22. ISSN 0021-9258. PMID 8798650.  
  10. ^ a b Fujita, M; Yamada C, Goto H, Yokoyama N, Kuzushima K, Inagaki M, Tsurumi T (Sep. 1999). "Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation". J. Biol. Chem. (UNITED STATES) 274 (36): 25927–32. ISSN 0021-9258. PMID 10464337.  
  11. ^ Fujita, Masatoshi; Ishimi Yukio, Nakamura Hiromu, Kiyono Tohru, Tsurumi Tatsuya (Mar. 2002). "Nuclear organization of DNA replication initiation proteins in mammalian cells". J. Biol. Chem. (United States) 277 (12): 10354–61. doi:10.1074/jbc.M111398200. ISSN 0021-9258. PMID 11779870.  
  12. ^ Wang, Y; Xu F, Hall F L (Oct. 2000). "The MAT1 cyclin-dependent kinase-activating kinase (CAK) assembly/targeting factor interacts physically with the MCM7 DNA licensing factor". FEBS Lett. (NETHERLANDS) 484 (1): 17–21. ISSN 0014-5793. PMID 11056214.  
  13. ^ You, Z; Komamura Y, Ishimi Y (Dec. 1999). "Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity". Mol. Cell. Biol. (UNITED STATES) 19 (12): 8003–15. ISSN 0270-7306. PMID 10567526.  
  14. ^ Kühne, C; Banks L (Dec. 1998). "E3-ubiquitin ligase/E6-AP links multicopy maintenance protein 7 to the ubiquitination pathway by a novel motif, the L2G box". J. Biol. Chem. (UNITED STATES) 273 (51): 34302–9. ISSN 0021-9258. PMID 9852095.  
  15. ^ Kukimoto, I; Igaki H, Kanda T (Nov. 1999). "Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha". Eur. J. Biochem. (GERMANY) 265 (3): 936–43. ISSN 0014-2956. PMID 10518787.  
  • Todorov IT, Lavigne J, Sakr F, et al. (1991). "Nuclear matrix protein mitotin messenger RNA is expressed at constant levels during the cell cycle.". Biochem. Biophys. Res. Commun. 177 (1): 395–400. doi:10.1016/0006-291X(91)91996-P. PMID 1710453.  
  • Musahl C, Schulte D, Burkhart R, Knippers R (1995). "A human homologue of the yeast replication protein Cdc21. Interactions with other Mcm proteins.". Eur. J. Biochem. 230 (3): 1096–101. PMID 7601140.  
  • Mincheva A, Todorov I, Werner D, et al. (1994). "The human gene for nuclear protein BM28 (CDCL1), a new member of the early S-phase family of proteins, maps to chromosome band 3q21.". Cytogenet. Cell Genet. 65 (4): 276–7. doi:10.1159/000133647. PMID 8258304.  
  • Hu B, Burkhart R, Schulte D, et al. (1994). "The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins.". Nucleic Acids Res. 21 (23): 5289–93. doi:10.1093/nar/21.23.5289-a. PMID 8265339.  
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.  
  • Fujita M, Kiyono T, Hayashi Y, Ishibashi M (1996). "hCDC47, a human member of the MCM family. Dissociation of the nucleus-bound form during S phase.". J. Biol. Chem. 271 (8): 4349–54. doi:10.1074/jbc.271.8.4349. PMID 8626784.  
  • Schulte D, Richter A, Burkhart R, et al. (1996). "Properties of the human nuclear protein p85Mcm. Expression, nuclear localization and interaction with other Mcm proteins.". Eur. J. Biochem. 235 (1-2): 144–51. doi:10.1111/j.1432-1033.1996.00144.x. PMID 8631321.  
  • Kiyono T, Fujita M, Hayashi Y, Ishibashi M (1996). "Cloning of a cDNA encoding a human homologue of CDC47, a member of the MCM family.". Biochim. Biophys. Acta 1307 (1): 31–4. PMID 8652665.  
  • Ishimi Y, Ichinose S, Omori A, et al. (1996). "Binding of human minichromosome maintenance proteins with histone H3.". J. Biol. Chem. 271 (39): 24115–22. doi:10.1074/jbc.271.39.24115. PMID 8798650.  
  • Fujita M, Kiyono T, Hayashi Y, Ishibashi M (1997). "In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP.". J. Biol. Chem. 272 (16): 10928–35. doi:10.1074/jbc.272.16.10928. PMID 9099751.  
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.  
  • Hiraiwa A, Fujita M, Nagasaka T, et al. (1997). "Immunolocalization of hCDC47 protein in normal and neoplastic human tissues and its relation to growth.". Int. J. Cancer 74 (2): 180–4. doi:10.1002/(SICI)1097-0215(19970422)74:2<180::AID-IJC7>3.0.CO;2-V. PMID 9133452.  
  • Ishimi Y (1997). "A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex.". J. Biol. Chem. 272 (39): 24508–13. doi:10.1074/jbc.272.39.24508. PMID 9305914.  
  • Sterner JM, Dew-Knight S, Musahl C, et al. (1998). "Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7.". Mol. Cell. Biol. 18 (5): 2748–57. PMID 9566894.  
  • Suzuki S, Adachi A, Hiraiwa A, et al. (1998). "Cloning and characterization of human MCM7 promoter.". Gene 216 (1): 85–91. doi:10.1016/S0378-1119(98)00323-0. PMID 9714754.  
  • Kühne C, Banks L (1999). "E3-ubiquitin ligase/E6-AP links multicopy maintenance protein 7 to the ubiquitination pathway by a novel motif, the L2G box.". J. Biol. Chem. 273 (51): 34302–9. doi:10.1074/jbc.273.51.34302. PMID 9852095.  
  • Fujita M, Yamada C, Goto H, et al. (1999). "Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation.". J. Biol. Chem. 274 (36): 25927–32. doi:10.1074/jbc.274.36.25927. PMID 10464337.  
  • Freeman A, Morris LS, Mills AD, et al. (1999). "Minichromosome maintenance proteins as biological markers of dysplasia and malignancy.". Clin. Cancer Res. 5 (8): 2121–32. PMID 10473096.  
  • Kukimoto I, Igaki H, Kanda T (1999). "Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha.". Eur. J. Biochem. 265 (3): 936–43. doi:10.1046/j.1432-1327.1999.00791.x. PMID 10518787.  
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