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Methylenedioxypyrovalerone
Systematic (IUPAC) name
(RS)-1-(benzo[d][1,3]dioxol-5-yl)-2-(pyrrolidin-1-yl)pentan-1-one
Identifiers
CAS number 687603-66-3
24622-62-6 (HCl)
ATC code  ?
PubChem 20111961
Chemical data
Formula C16H21NO3 
Mol. mass 275.35 g/mol
Pharmacokinetic data
Half life 3 to 5 hours[citation needed]
Therapeutic considerations
Pregnancy cat.  ?
Legal status Unscheduled (illegal in Denmark and Sweden)
Routes Oral, Insufflation, Intravenous, Rectal, Vaporization

Methylenedioxypyrovalerone (MDPV) is a psychoactive drug with stimulant properties which acts as a norepinephrine-dopamine reuptake inhibitor (NDRI), reportedly with four times the potency of methylphenidate (Ritalin, Concerta).[1] MDPV has no history of FDA approved medical use but has been sold since around 2007 as a research chemical.[2]

Contents

Appearance

The substance appears as a pure white to light-brown, significantly hydrophilic crumbly powder with a slight odour. It appears to darken slightly in colour and take on a potato-tuber-like odor if exposed to air for any significant length of time. In some of the first batches that appeared on the research chemical market, an impurity was identified and said to consist of pyrrolidine, which could account for its earthy odour when left uncapped. It has also been observed to rapidly degrade and lose potency when in solution.

Effects

MDPV acts as a stimulant. Thus, the acute effects include:

  • physical: rapid heartbeat, increase in blood pressure, vasoconstriction, sweating
  • mental: increases in alertness & awareness, increased wakefulness and arousal, euphoria, anxiety, agitation, perception of a diminished requirement for food and sleep.

The effects have a duration of roughly 3 to 4 hours, with after effects such as tachycardia, hypertension, and mild stimulation lasting from 6 to 8 hours. High doses have been observed to cause intense, prolonged panic attacks in stimulant-intolerant users, and there are anecdotal reports of psychosis from sleep withdrawal and addiction at higher doses or more frequent dosing intervals. MDPV has been remarked about more than once for its powers as an aphrodisiac, which have been said to rival those of methamphetamine when dosed correctly. Users often report to feel compelled to continue redosing but then lose interest in taking it quickly because of the unpleasant side effects caused by higher doses.

MDPV is the 3,4-methylenedioxy ring-substituted analogue of the anorectic or appetite suppressant pyrovalerone. However, despite its structural similarity, the effects of MDPV bear little resemblance to other methylenedioxyphenylalkylamine derivatives such as 3,4-methylenedioxy-N-methylamphetamine (MDMA), instead producing purely stimulant effects with no entactogenic qualities. Extended binges on MDPV have also been reported to produce severe comedown syndrome similar to that of methamphetamine, characterized by depression, lethargy, headache, anxiety, postural hypotension (lightheadedness and weakness of the muscles), and in some cases severely bloodshot eyes. Time is the solution for these symptoms, which usually subside within 4 to 8 hours. Abdominal pain consistent with kidney pain has also been reported when MDPV is used for extended periods of time.[3] MDPV may also cause temporary trismus and/or bruxism. Side effects are highly dose-dependant.

Legality

MDPV is not specifically listed as a controlled substance in any country besides Denmark and Sweden.

Other drugs with a similar chemical structure include α-pyrrolidinopropiophenone (α-PPP), which has a shorter alkyl chain and no ring substitution, pyrovalerone, which has a 4'-methyl group instead of a methylenedioxy ring, as well as analogues with between 3 and 6 carbons on the alkyl chain.[4]

These compounds have been reported as stimulants of abuse mainly in Germany and other European countries since the early 2000s, but they have remained generally vaguely known and rarely used illicitly or encountered by law enforcement.[5]

In March 2010 dead drug abusers have been found to have large quantities of MDPV in their bodies in Finland. These quantities have been large enough to be a possible cause of death, although this hasn't yet been officially stated. [6]

References

  1. ^ 1-[(3,4-Methylenedioxy)phenyl]-2-pyrrolidino-1-alkanones as stimulants. (Boehringer Ingelheim G.m.b.H.). Brit. (1969), 7 pp. CODEN: BRXXAA GB 1149366 19690423 Patent written in English. Priority: DE 19650523. CAN 72:21608 AN 1970:21608 CAPLUS
  2. ^ Westphal F, Junge T, Rösner P, Sönnichsen F, Schuster F (June 2009). "Mass and NMR spectroscopic characterization of 3,4-methylenedioxypyrovalerone: A designer drug with alpha-pyrrolidinophenone structure". Forensic Science International. doi:10.1016/j.forsciint.2009.05.001. PMID 19500924. 
  3. ^ MDPV Experience Report(s) - Drugs Forum
  4. ^ Meltzer PC, Butler D, Deschamps JR, Madras BK. 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. Journal of Medicinal Chemistry. 2006 Feb 23;49(4):1420-32.
  5. ^ Springer D, Fritschi G, Maurer HH. Metabolism of the new designer drug alpha-pyrrolidinopropiophenone (PPP) and the toxicological detection of PPP and 4'-methyl-alpha-pyrrolidinopropiophenone (MPPP) studied in rat urine using gas chromatography-mass spectrometry. Journal of Chromatography B, Analytical Technologies in the Biomedical Life Sciences. 2003 Nov 5;796(2):253-66.
  6. ^ Interview with head of the Department of Forensic Medicine at the University of Helsinki, Helsingin Sanomat 16.3.2010 http://www.hs.fi/kaupunki/artikkeli/Designhuume+yleistynyt+p%C3%A4%C3%A4kaupunkiseudulla/1135254435679

External links


MDPV
Systematic (IUPAC) name
1-(benzo[d][1,3]dioxol-5-yl)-2-(pyrrolidin-1-yl)pentan-1-one
Identifiers
CAS number 687603-66-3 24622-62-6 (Hydrochloride)
ATC code  ?
PubChem 20111961
Chemical data
Formula C16H21NO3 
Mol. mass 275.35 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status

unscheduled (illegal in Denmark)

Routes oral, insufflation, intravenous

Methylenedioxypyrovalerone, also known as MDPV or MDPK, is a stimulant drug which acts as a norepinephrine and dopamine reuptake inhibitor, reportedly with four times the potency of methylphenidate.[1] This compound is reported to be used as a stimulant and an aphrodisiac. It has no history of medical use but has been sold as a designer drug for recreational use.

Contents

Appearance

The substance appears as a pure white to light-brown, significantly hydrophilic crumbly powder with a slight odour. It appears to darken slightly in colour and take on a potato-tuber-like odor if exposed to air for any significant length of time.[2] In some of the first batches that appeared on the research chemical market, an impurity was identified and said to consist of pyrrolidine, which could account for its earthy odour when left uncapped. It has also been observed to rapidly degrade and lose potency when in solution.

Effects

Subjective effects include CNS stimulation, euphoria, hypersexuality, agitation/anxiety and insomnia, with a duration of three to four hours, with aftereffects such as high BPM and CNS stimulation lasting from six to eight hours. High doses have been observed to cause intense, prolonged anxiety attacks in stimulant-intolerant users, and there are anecdotal reports of addiction at higher doses or more frequent dosing intervals. MDPV has been remarked about more than once for its powers as an aphrodisiac, which have been said to rival those of methamphetamine when dosed correctly.[3] Users often report to feel compelled to continue redosing, usually not due to the main stimulating effects of the drug, but due to the desire to retain the pro-sexual aphrodisiac qualitites experienced.

MDPV is the 3,4-methylenedioxy ring-substituted analogue of the appetite suppressant pyrovalerone, however despite its structural similarity the effects of MDPV bear little resemblance to other methylenedioxyphenylalkylamine derivatives such as MDMA and methylone, instead producing purely stimulant effects with no empathogenic qualities. Extended binges on MDPV have also been reported to produce severe come-down syndrome similar to that of methamphetamine and characterised by depression, lethargy, headache, anxiety, postural hypotension (lightheadedness and weakness of muscles) and in some cases severely bloodshot eyes. Time is the solution for these symptoms, which usually subside within four to eight hours. Kidney and liver pain has also been reported when MDPV is used for extended periods.[4] [5] [6] MDPV may also cause severe bruxism and strong disco fever.

Legality

MDPV is not specifically listed as an illegal drug in any country besides Denmark. Furthermore, MDPV is not illegal under the US Federal Analog Act as the legislation only applies to schedule I and II drugs, and pyrovalerone is schedule V under the US Controlled Substances Act. Other drugs with a similar structure include alpha-pyrrolidinopropiophenone, which has a shorter alkyl chain and no ring substitution, pyrovalerone, which has a 4'-methyl group instead of a methylenedioxy ring, as well as analogues with between 3 and 6 carbons on the alkyl chain.[7] These compounds have been reported as stimulants of abuse mainly in Germany and other European countries since the early 2000s, but they have remained little known and rarely used or encountered by law enforcement.[8]

References

  1. 1-[(3,4-Methylenedioxy)phenyl]-2-pyrrolidino-1-alkanones as stimulants. (Boehringer Ingelheim G.m.b.H.). Brit. (1969), 7 pp. CODEN: BRXXAA GB 1149366 19690423 Patent written in English. Priority: DE 19650523. CAN 72:21608 AN 1970:21608 CAPLUS
  2. 1-(3,4-methylenedioxy-phenyl)-2-pyrrolidin-1-yl-pentan-1-one - Bluelight
  3. Bluelight - View Single Post - The MDPV Discussion Thread
  4. 1-(3,4-methylenedioxy-phenyl)-2-pyrrolidin-1-yl-pentan-1-one - Bluelight
  5. Erowid Experience Vaults: MDPV - Diet MDE - 47047
  6. MDPV Experience Report(s) - Drugs Forum
  7. Meltzer PC, Butler D, Deschamps JR, Madras BK. 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. Journal of Medicinal Chemistry. 2006 Feb 23;49(4):1420-32.
  8. Springer D, Fritschi G, Maurer HH. Metabolism of the new designer drug alpha-pyrrolidinopropiophenone (PPP) and the toxicological detection of PPP and 4'-methyl-alpha-pyrrolidinopropiophenone (MPPP) studied in rat urine using gas chromatography-mass spectrometry. Journal of Chromatography B, Analytical Technologies in the Biomedical Life Sciences. 2003 Nov 5;796(2):253-66.

External links


Also known as MONKEY DUST








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