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MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C)

PDB rendering based on 1c7u.
Available structures
1c7u, 1egw
Identifiers
Symbols MEF2C;
External IDs OMIM600662 MGI99458 HomoloGene31087 GeneCards: MEF2C Gene
RNA expression pattern
PBB GE MEF2C 209199 s at tn.png
PBB GE MEF2C 207968 s at tn.png
PBB GE MEF2C 209200 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4208 17260
Ensembl ENSG00000081189 ENSMUSG00000005583
UniProt Q06413 n/a
RefSeq (mRNA) NM_002397 NM_025282
RefSeq (protein) NP_002388 NP_079558
Location (UCSC) Chr 5:
88.05 - 88.21 Mb
Chr 13:
83.98 - 84.14 Mb
PubMed search [1] [2]

MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C), also known as MEF2C, is a transcription factor in the Mef2 family.[1][2] The Mef2c gene is necessary for proper embryonic development: mice without a functional copy of the Mef2c gene die before birth and have abnormalities in the heart and vascular system.[3]

Contents

Interactions

MEF2C has been shown to interact with MAPK7,[4] EP300,[5] Sp1 transcription factor,[6] TEAD1,[7] SOX18[8] and HDAC4.[9][10]

See also

References

  1. ^ Molkentin JD, Black BL, Martin JF, Olson EN (1996). "Mutational analysis of the DNA binding, dimerization, and transcriptional activation domains of MEF2C.". Mol Cell Biol. 16 (6): 2627–36. PMID 8649370.  
  2. ^ "Entrez Gene: MEF2C myocyte enhancer factor 2C". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4208.  
  3. ^ Bi W, Drake CJ, Schwarz JJ (1999). "The transcription factor MEF2C-null mouse exhibits complex vascular malformations and reduced cardiac expression of angiopoietin 1 and VEGF". Developmental Biology 211 (2): 255–67. doi:10.1006/dbio.1999.9307. PMID 10395786.  
  4. ^ Yang, C C; Ornatsky O I, McDermott J C, Cruz T F, Prody C A (Oct. 1998). "Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1". Nucleic Acids Res. (ENGLAND) 26 (20): 4771–7. ISSN 0305-1048. PMID 9753748.  
  5. ^ Sartorelli, V; Huang J, Hamamori Y, Kedes L (Feb. 1997). "Molecular mechanisms of myogenic coactivation by p300: direct interaction with the activation domain of MyoD and with the MADS box of MEF2C". Mol. Cell. Biol. (UNITED STATES) 17 (2): 1010–26. ISSN 0270-7306. PMID 9001254.  
  6. ^ Krainc, D; Bai G, Okamoto S, Carles M, Kusiak J W, Brent R N, Lipton S A (Oct. 1998). "Synergistic activation of the N-methyl-D-aspartate receptor subunit 1 promoter by myocyte enhancer factor 2C and Sp1". J. Biol. Chem. (UNITED STATES) 273 (40): 26218–24. ISSN 0021-9258. PMID 9748305.  
  7. ^ Maeda, Tomoji; Gupta Mahesh P, Stewart Alexandre F R (Jun. 2002). "TEF-1 and MEF2 transcription factors interact to regulate muscle-specific promoters". Biochem. Biophys. Res. Commun. (United States) 294 (4): 791–7. doi:10.1016/S0006-291X(02)00556-9. ISSN 0006-291X. PMID 12061776.  
  8. ^ Hosking, B M; Wang S C, Chen S L, Penning S, Koopman P, Muscat G E (Sep. 2001). "SOX18 directly interacts with MEF2C in endothelial cells". Biochem. Biophys. Res. Commun. (United States) 287 (2): 493–500. doi:10.1006/bbrc.2001.5589. ISSN 0006-291X. PMID 11554755.  
  9. ^ Wang, A H; Bertos N R, Vezmar M, Pelletier N, Crosato M, Heng H H, Th'ng J, Han J, Yang X J (Nov. 1999). "HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor". Mol. Cell. Biol. (UNITED STATES) 19 (11): 7816–27. ISSN 0270-7306. PMID 10523670.  
  10. ^ Wang, A H; Yang X J (Sep. 2001). "Histone deacetylase 4 possesses intrinsic nuclear import and export signals". Mol. Cell. Biol. (United States) 21 (17): 5992–6005. ISSN 0270-7306. PMID 11486037.  

Further reading

  • Leifer D, Krainc D, Yu YT, et al. (1993). "MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex.". Proc. Natl. Acad. Sci. U.S.A. 90 (4): 1546–50. doi:10.1073/pnas.90.4.1546. PMID 7679508.  
  • McDermott JC, Cardoso MC, Yu YT, et al. (1993). "hMEF2C gene encodes skeletal muscle- and brain-specific transcription factors.". Mol. Cell. Biol. 13 (4): 2564–77. PMID 8455629.  
  • Hobson GM, Krahe R, Garcia E, et al. (1996). "Regional chromosomal assignments for four members of the MADS domain transcription enhancer factor 2 (MEF2) gene family to human chromosomes 15q26, 19p12, 5q14, and 1q12-q23.". Genomics 29 (3): 704–11. doi:10.1006/geno.1995.9007. PMID 8575763.  
  • Krainc D, Haas M, Ward DC, et al. (1996). "Assignment of human myocyte-specific enhancer binding factor 2C (hMEF2C) to human chromosome 5q14 and evidence that MEF2C is evolutionarily conserved.". Genomics 29 (3): 809–11. doi:10.1006/geno.1995.9927. PMID 8575784.  
  • Molkentin JD, Li L, Olson EN (1996). "Phosphorylation of the MADS-Box transcription factor MEF2C enhances its DNA binding activity.". J. Biol. Chem. 271 (29): 17199–204. doi:10.1074/jbc.271.29.17199. PMID 8663403.  
  • Black BL, Ligon KL, Zhang Y, Olson EN (1996). "Cooperative transcriptional activation by the neurogenic basic helix-loop-helix protein MASH1 and members of the myocyte enhancer factor-2 (MEF2) family.". J. Biol. Chem. 271 (43): 26659–63. doi:10.1074/jbc.271.43.26659. PMID 8900141.  
  • Gradwohl G, Fode C, Guillemot F (1997). "Restricted expression of a novel murine atonal-related bHLH protein in undifferentiated neural precursors.". Dev. Biol. 180 (1): 227–41. doi:10.1006/dbio.1996.0297. PMID 8948587.  
  • Sartorelli V, Huang J, Hamamori Y, Kedes L (1997). "Molecular mechanisms of myogenic coactivation by p300: direct interaction with the activation domain of MyoD and with the MADS box of MEF2C.". Mol. Cell. Biol. 17 (2): 1010–26. PMID 9001254.  
  • Han J, Jiang Y, Li Z, et al. (1997). "Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation.". Nature 386 (6622): 296–9. doi:10.1038/386296a0. PMID 9069290.  
  • Kato Y, Kravchenko VV, Tapping RI, et al. (1998). "BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C.". Embo J. 16 (23): 7054–66. doi:10.1093/emboj/16.23.7054. PMID 9384584.  
  • Krainc D, Bai G, Okamoto S, et al. (1998). "Synergistic activation of the N-methyl-D-aspartate receptor subunit 1 promoter by myocyte enhancer factor 2C and Sp1.". J. Biol. Chem. 273 (40): 26218–24. doi:10.1074/jbc.273.40.26218. PMID 9748305.  
  • Yang CC, Ornatsky OI, McDermott JC, et al. (1998). "Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1.". Nucleic Acids Res. 26 (20): 4771–7. doi:10.1093/nar/26.20.4771. PMID 9753748.  
  • Swanson BJ, Jäck HM, Lyons GE (1998). "Characterization of myocyte enhancer factor 2 (MEF2) expression in B and T cells: MEF2C is a B cell-restricted transcription factor in lymphocytes.". Mol. Immunol. 35 (8): 445–58. doi:10.1016/S0161-5890(98)00058-3. PMID 9798649.  
  • Zhao M, New L, Kravchenko VV, et al. (1999). "Regulation of the MEF2 family of transcription factors by p38.". Mol. Cell. Biol. 19 (1): 21–30. PMID 9858528.  
  • Wilson-Rawls J, Molkentin JD, Black BL, Olson EN (1999). "Activated notch inhibits myogenic activity of the MADS-Box transcription factor myocyte enhancer factor 2C.". Mol. Cell. Biol. 19 (4): 2853–62. PMID 10082551.  
  • Yang SH, Galanis A, Sharrocks AD (1999). "Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors.". Mol. Cell. Biol. 19 (6): 4028–38. PMID 10330143.  
  • Wang AH, Bertos NR, Vezmar M, et al. (1999). "HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor.". Mol. Cell. Biol. 19 (11): 7816–27. PMID 10523670.  
  • Lu J, McKinsey TA, Nicol RL, Olson EN (2000). "Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases.". Proc. Natl. Acad. Sci. U.S.A. 97 (8): 4070–5. doi:10.1073/pnas.080064097. PMID 10737771.  
  • Morin S, Charron F, Robitaille L, Nemer M (2000). "GATA-dependent recruitment of MEF2 proteins to target promoters.". Embo J. 19 (9): 2046–55. doi:10.1093/emboj/19.9.2046. PMID 10790371.  
  • Wu Z, Woodring PJ, Bhakta KS, et al. (2000). "p38 and extracellular signal-regulated kinases regulate the myogenic program at multiple steps.". Mol. Cell. Biol. 20 (11): 3951–64. doi:10.1128/MCB.20.11.3951-3964.2000. PMID 10805738.  

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