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MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D)

PDB rendering based on 1c7u.
Available structures
1c7u, 1egw
Identifiers
Symbols MEF2D; DKFZp686I1536
External IDs OMIM600663 MGI99533 HomoloGene4327 GeneCards: MEF2D Gene
RNA expression pattern
PBB GE MEF2D 203003 at tn.png
PBB GE MEF2D 203004 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4209 17261
Ensembl ENSG00000116604 ENSMUSG00000001419
UniProt Q14814 Q3URR2
RefSeq (mRNA) NM_005920 XM_987375
RefSeq (protein) NP_005911 XP_992469
Location (UCSC) Chr 1:
154.7 - 154.74 Mb
Chr 3:
88.23 - 88.25 Mb
PubMed search [1] [2]

Myocyte-specific enhancer factor 2D is a protein that in humans is encoded by the MEF2D gene.[1][2]

Contents

Interactions

MEF2D has been shown to interact with YWHAQ,[3] MAPK7,[4] EP300,[5][6] Sp1 transcription factor,[7] Myocyte-specific enhancer factor 2A,[8] NFATC2[9] and CABIN1.[6][10]

See also

References

  1. ^ Breitbart RE, Liang CS, Smoot LB, Laheru DA, Mahdavi V, Nadal-Ginard B (Feb 1994). "A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage". Development 118 (4): 1095–106. PMID 8269842.  
  2. ^ "Entrez Gene: MEF2D MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4209.  
  3. ^ Choi, S J; Park S Y, Han T H (Jul. 2001). "14-3-3tau associates with and activates the MEF2D transcription factor during muscle cell differentiation". Nucleic Acids Res. (England) 29 (13): 2836–42. PMID 11433030.  
  4. ^ Yang, C C; Ornatsky O I, McDermott J C, Cruz T F, Prody C A (Oct. 1998). "Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1". Nucleic Acids Res. (ENGLAND) 26 (20): 4771–7. ISSN 0305-1048. PMID 9753748.  
  5. ^ Youn, H D; Grozinger C M, Liu J O (Jul. 2000). "Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4". J. Biol. Chem. (UNITED STATES) 275 (29): 22563–7. doi:10.1074/jbc.C000304200. ISSN 0021-9258. PMID 10825153.  
  6. ^ a b Youn, H D; Liu J O (Jul. 2000). "Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2". Immunity (UNITED STATES) 13 (1): 85–94. ISSN 1074-7613. PMID 10933397.  
  7. ^ Park, So-Youn; Shin Hyun-Mu, Han Tae-Hee (Sep. 2002). "Synergistic interaction of MEF2D and Sp1 in activation of the CD14 promoter". Mol. Immunol. (England) 39 (1-2): 25–30. ISSN 0161-5890. PMID 12213324.  
  8. ^ Ornatsky, O I; McDermott J C (Oct. 1996). "MEF2 protein expression, DNA binding specificity and complex composition, and transcriptional activity in muscle and non-muscle cells". J. Biol. Chem. (UNITED STATES) 271 (40): 24927–33. ISSN 0021-9258. PMID 8798771.  
  9. ^ Youn, H D; Chatila T A, Liu J O (Aug. 2000). "Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis". EMBO J. (ENGLAND) 19 (16): 4323–31. doi:10.1093/emboj/19.16.4323. ISSN 0261-4189. PMID 10944115.  
  10. ^ Youn, H D; Sun L, Prywes R, Liu J O (Oct. 1999). "Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2". Science (UNITED STATES) 286 (5440): 790–3. ISSN 0036-8075. PMID 10531067.  

Further reading

  • Hobson GM, Krahe R, Garcia E, et al. (1996). "Regional chromosomal assignments for four members of the MADS domain transcription enhancer factor 2 (MEF2) gene family to human chromosomes 15q26, 19p12, 5q14, and 1q12-q23.". Genomics 29 (3): 704–11. doi:10.1006/geno.1995.9007. PMID 8575763.  
  • Ornatsky OI, McDermott JC (1996). "MEF2 protein expression, DNA binding specificity and complex composition, and transcriptional activity in muscle and non-muscle cells.". J. Biol. Chem. 271 (40): 24927–33. doi:10.1074/jbc.271.40.24927. PMID 8798771.  
  • Yang CC, Ornatsky OI, McDermott JC, et al. (1998). "Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1.". Nucleic Acids Res. 26 (20): 4771–7. doi:10.1093/nar/26.20.4771. PMID 9753748.  
  • Zhao M, New L, Kravchenko VV, et al. (1999). "Regulation of the MEF2 family of transcription factors by p38.". Mol. Cell. Biol. 19 (1): 21–30. PMID 9858528.  
  • Wang AH, Bertos NR, Vezmar M, et al. (1999). "HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor.". Mol. Cell. Biol. 19 (11): 7816–27. PMID 10523670.  
  • Lu J, McKinsey TA, Nicol RL, Olson EN (2000). "Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases.". Proc. Natl. Acad. Sci. U.S.A. 97 (8): 4070–5. doi:10.1073/pnas.080064097. PMID 10737771.  
  • Kato Y, Zhao M, Morikawa A, et al. (2000). "Big mitogen-activated kinase regulates multiple members of the MEF2 protein family.". J. Biol. Chem. 275 (24): 18534–40. doi:10.1074/jbc.M001573200. PMID 10849446.  
  • Youn HD, Chatila TA, Liu JO (2000). "Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis.". Embo J. 19 (16): 4323–31. doi:10.1093/emboj/19.16.4323. PMID 10944115.  
  • Slepak TI, Webster KA, Zang J, et al. (2001). "Control of cardiac-specific transcription by p300 through myocyte enhancer factor-2D.". J. Biol. Chem. 276 (10): 7575–85. doi:10.1074/jbc.M004625200. PMID 11096067.  
  • Choi SJ, Park SY, Han TH (2001). "14-3-3tau associates with and activates the MEF2D transcription factor during muscle cell differentiation.". Nucleic Acids Res. 29 (13): 2836–42. doi:10.1093/nar/29.13.2836. PMID 11433030.  
  • Okamoto S, Li Z, Ju C, et al. (2002). "Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis.". Proc. Natl. Acad. Sci. U.S.A. 99 (6): 3974–9. doi:10.1073/pnas.022036399. PMID 11904443.  
  • Park SY, Shin HM, Han TH (2002). "Synergistic interaction of MEF2D and Sp1 in activation of the CD14 promoter.". Mol. Immunol. 39 (1-2): 25–30. doi:10.1016/S0161-5890(02)00055-X. PMID 12213324.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Linseman DA, Bartley CM, Le SS, et al. (2003). "Inactivation of the myocyte enhancer factor-2 repressor histone deacetylase-5 by endogenous Ca(2+) //calmodulin-dependent kinase II promotes depolarization-mediated cerebellar granule neuron survival.". J. Biol. Chem. 278 (42): 41472–81. doi:10.1074/jbc.M307245200. PMID 12896970.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Grégoire S, Yang XJ (2005). "Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors.". Mol. Cell. Biol. 25 (6): 2273–87. doi:10.1128/MCB.25.6.2273-2287.2005. PMID 15743823.  
  • Prima V, Gore L, Caires A, et al. (2005). "Cloning and functional characterization of MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins created by a variant t(1;19)(q23;p13.3) in acute lymphoblastic leukemia.". Leukemia 19 (5): 806–13. doi:10.1038/sj.leu.2403684. PMID 15744350.  

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