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Meis homeobox 1
Symbols MEIS1; MGC43380
External IDs OMIM601739 MGI104717 HomoloGene86803 GeneCards: MEIS1 Gene
RNA expression pattern
PBB GE MEIS1 204069 at tn.png
More reference expression data
Species Human Mouse
Entrez 4211 17268
Ensembl ENSG00000143995 ENSMUSG00000020160
UniProt O00470 Q3UJ00
RefSeq (mRNA) NM_002398 NM_010789
RefSeq (protein) NP_002389 NP_034919
Location (UCSC) Chr 2:
66.52 - 66.65 Mb
Chr 11:
18.78 - 18.92 Mb
PubMed search [1] [2]

Homeobox protein Meis1 is a protein that in humans is encoded by the MEIS1 gene.[1][2]

Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins.[2]



MEIS1 has been shown to interact with PBX1[3][4][5] and HOXA9.[6][3]


  1. ^ Moskow JJ, Bullrich F, Huebner K, Daar IO, Buchberg AM (Oct 1995). "Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice". Mol Cell Biol 15 (10): 5434–43. PMID 7565694.  
  2. ^ a b "Entrez Gene: MEIS1 Meis homeobox 1".  
  3. ^ a b Shen, W F; Rozenfeld S, Kwong A, Köm ves L G, Lawrence H J, Largman C (Apr. 1999). "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells". Mol. Cell. Biol. (UNITED STATES) 19 (4): 3051–61. ISSN 0270-7306. PMID 10082572.  
  4. ^ Shanmugam, K; Green N C, Rambaldi I, Saragovi H U, Featherstone M S (Nov. 1999). "PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins". Mol. Cell. Biol. (UNITED STATES) 19 (11): 7577–88. ISSN 0270-7306. PMID 10523646.  
  5. ^ Jacobs, Y; Schnabel C A, Cleary M L (Jul. 1999). "Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity". Mol. Cell. Biol. (UNITED STATES) 19 (7): 5134–42. ISSN 0270-7306. PMID 10373562.  
  6. ^ Shen, W F; Montgomery J C, Rozenfeld S, Moskow J J, Lawrence H J, Buchberg A M, Largman C (Nov. 1997). "AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins". Mol. Cell. Biol. (UNITED STATES) 17 (11): 6448–58. ISSN 0270-7306. PMID 9343407.  

Further reading

  • Allen TD, Zhu YX, Hawley TS, Hawley RG (2001). "TALE homeoproteins as HOX11-interacting partners in T-cell leukemia.". Leuk. Lymphoma 39 (3-4): 241–56. PMID 11342305.  
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  
  • Steelman S, Moskow JJ, Muzynski K, et al. (1997). "Identification of a conserved family of Meis1-related homeobox genes.". Genome Res. 7 (2): 142–56. doi:10.1101/gr.7.2.142. PMID 9049632.  
  • Smith JE, Bollekens JA, Inghirami G, Takeshita K (1997). "Cloning and mapping of the MEIS1 gene, the human homolog of a murine leukemogenic gene.". Genomics 43 (1): 99–103. doi:10.1006/geno.1997.4766. PMID 9226379.  
  • Shen WF, Montgomery JC, Rozenfeld S, et al. (1997). "AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins.". Mol. Cell. Biol. 17 (11): 6448–58. PMID 9343407.  
  • Knoepfler PS, Calvo KR, Chen H, et al. (1998). "Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1.". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14553–8. doi:10.1073/pnas.94.26.14553. PMID 9405651.  
  • "Toward a complete human genome sequence.". Genome Res. 8 (11): 1097–108. 1999. PMID 9847074.  
  • Shen WF, Rozenfeld S, Kwong A, et al. (1999). "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells.". Mol. Cell. Biol. 19 (4): 3051–61. PMID 10082572.  
  • Jacobs Y, Schnabel CA, Cleary ML (1999). "Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity.". Mol. Cell. Biol. 19 (7): 5134–42. PMID 10373562.  
  • Knoepfler PS, Bergstrom DA, Uetsuki T, et al. (1999). "A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1.". Nucleic Acids Res. 27 (18): 3752–61. doi:10.1093/nar/27.18.3752. PMID 10471746.  
  • Shanmugam K, Green NC, Rambaldi I, et al. (1999). "PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins.". Mol. Cell. Biol. 19 (11): 7577–88. PMID 10523646.  
  • Spieker N, van Sluis P, Beitsma M, et al. (2001). "The MEIS1 oncogene is highly expressed in neuroblastoma and amplified in cell line IMR32.". Genomics 71 (2): 214–21. doi:10.1006/geno.2000.6408. PMID 11161815.  
  • Wang Y, Yin L, Hillgartner FB (2001). "The homeodomain proteins PBX and MEIS1 are accessory factors that enhance thyroid hormone regulation of the malic enzyme gene in hepatocytes.". J. Biol. Chem. 276 (26): 23838–48. doi:10.1074/jbc.M102166200. PMID 11331288.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Okada Y, Nagai R, Sato T, et al. (2004). "Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene.". Blood 101 (12): 4748–56. doi:10.1182/blood-2002-02-0380. PMID 12609849.  
  • Zeisig BB, Milne T, García-Cuéllar MP, et al. (2004). "Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization.". Mol. Cell. Biol. 24 (2): 617–28. doi:10.1128/MCB.24.2.617-628.2004. PMID 14701735.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Pineault N, Abramovich C, Ohta H, Humphries RK (2004). "Differential and common leukemogenic potentials of multiple NUP98-Hox fusion proteins alone or with Meis1.". Mol. Cell. Biol. 24 (5): 1907–17. doi:10.1128/MCB.24.5.1907-1917.2004. PMID 14966272.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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