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Mesenchyme homeobox 2
Symbols MEOX2; GAX; MOX2
External IDs OMIM600535 MGI103219 HomoloGene4330 GeneCards: MEOX2 Gene
RNA expression pattern
PBB GE MEOX2 206201 s at tn.png
More reference expression data
Species Human Mouse
Entrez 4223 17286
Ensembl ENSG00000106511 ENSMUSG00000036144
UniProt P50222 Q99M23
RefSeq (mRNA) NM_005924 NM_008584
RefSeq (protein) NP_005915 NP_032610
Location (UCSC) Chr 7:
15.62 - 15.69 Mb
Chr 12:
37.62 - 37.69 Mb
PubMed search [1] [2]

Homeobox protein MOX-2 is a protein that in humans is encoded by the MEOX2 gene.[1][2]

This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease.[2]



MEOX2 has been shown to interact with PAX1[3] and PAX3.[3]


  1. ^ LePage DF, Altomare DA, Testa JR, Walsh K (May 1995). "Molecular cloning and localization of the human GAX gene to 7p21". Genomics 24 (3): 535–40. doi:10.1006/geno.1994.1663. PMID 7713505.  
  2. ^ a b "Entrez Gene: MEOX2 mesenchyme homeobox 2".  
  3. ^ a b Stamataki, D; Kastrinaki M, Mankoo B S, Pachnis V, Karagogeos D (Jun. 2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors". FEBS Lett. (Netherlands) 499 (3): 274–8. ISSN 0014-5793. PMID 11423130.  

Further reading

  • Grigoriou M, Kastrinaki MC, Modi WS, et al. (1995). "Isolation of the human MOX2 homeobox gene and localization to chromosome 7p22.1-p21.3.". Genomics 26 (3): 550–5. doi:10.1016/0888-7543(95)80174-K. PMID 7607679.  
  • Reardon W, McManus SP, Summers D, Winter RM (1994). "Cytogenetic evidence that the Saethre-Chotzen gene maps to 7p21.2.". Am. J. Med. Genet. 47 (5): 633–6. doi:10.1002/ajmg.1320470510. PMID 8266988.  
  • Quinn LM, Latham SE, Kalionis B (2000). "The homeobox genes MSX2 and MOX2 are candidates for regulating epithelial-mesenchymal cell interactions in the human placenta.". Placenta 21 Suppl A: S50–4. doi:10.1053/plac.1999.0514. PMID 10831122.  
  • Stamataki D, Kastrinaki M, Mankoo BS, et al. (2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors.". FEBS Lett. 499 (3): 274–8. doi:10.1016/S0014-5793(01)02556-X. PMID 11423130.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.  
  • Gorski DH, Leal AJ (2003). "Inhibition of endothelial cell activation by the homeobox gene Gax.". J. Surg. Res. 111 (1): 91–9. doi:10.1016/S0022-4804(03)00042-8. PMID 12842453.  
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Wu Z, Guo H, Chow N, et al. (2005). "Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease.". Nat. Med. 11 (9): 959–65. doi:10.1038/nm1287. PMID 16116430.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Lin J, Friesen MT, Bocangel P, et al. (2006). "Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10.". Mol. Cell. Biochem. 275 (1-2): 75–84. doi:10.1007/s11010-005-0823-3. PMID 16335786.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  
  • Chen Y, Leal AD, Patel S, Gorski DH (2007). "The homeobox gene GAX activates p21WAF1/CIP1 expression in vascular endothelial cells through direct interaction with upstream AT-rich sequences.". J. Biol. Chem. 282 (1): 507–17. doi:10.1074/jbc.M606604200. PMID 17074759.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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