The Full Wiki

More info on MEOX2

MEOX2: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

edit
Mesenchyme homeobox 2
Identifiers
Symbols MEOX2; GAX; MOX2
External IDs OMIM600535 MGI103219 HomoloGene4330 GeneCards: MEOX2 Gene
RNA expression pattern
PBB GE MEOX2 206201 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4223 17286
Ensembl ENSG00000106511 ENSMUSG00000036144
UniProt P50222 Q99M23
RefSeq (mRNA) NM_005924 NM_008584
RefSeq (protein) NP_005915 NP_032610
Location (UCSC) Chr 7:
15.62 - 15.69 Mb
Chr 12:
37.62 - 37.69 Mb
PubMed search [1] [2]

Homeobox protein MOX-2 is a protein that in humans is encoded by the MEOX2 gene.[1][2]

This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease.[2]

Contents

Interactions

MEOX2 has been shown to interact with PAX1[3] and PAX3.[3]

References

  1. ^ LePage DF, Altomare DA, Testa JR, Walsh K (May 1995). "Molecular cloning and localization of the human GAX gene to 7p21". Genomics 24 (3): 535–40. doi:10.1006/geno.1994.1663. PMID 7713505.  
  2. ^ a b "Entrez Gene: MEOX2 mesenchyme homeobox 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4223.  
  3. ^ a b Stamataki, D; Kastrinaki M, Mankoo B S, Pachnis V, Karagogeos D (Jun. 2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors". FEBS Lett. (Netherlands) 499 (3): 274–8. ISSN 0014-5793. PMID 11423130.  

Further reading

  • Grigoriou M, Kastrinaki MC, Modi WS, et al. (1995). "Isolation of the human MOX2 homeobox gene and localization to chromosome 7p22.1-p21.3.". Genomics 26 (3): 550–5. doi:10.1016/0888-7543(95)80174-K. PMID 7607679.  
  • Reardon W, McManus SP, Summers D, Winter RM (1994). "Cytogenetic evidence that the Saethre-Chotzen gene maps to 7p21.2.". Am. J. Med. Genet. 47 (5): 633–6. doi:10.1002/ajmg.1320470510. PMID 8266988.  
  • Quinn LM, Latham SE, Kalionis B (2000). "The homeobox genes MSX2 and MOX2 are candidates for regulating epithelial-mesenchymal cell interactions in the human placenta.". Placenta 21 Suppl A: S50–4. doi:10.1053/plac.1999.0514. PMID 10831122.  
  • Stamataki D, Kastrinaki M, Mankoo BS, et al. (2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors.". FEBS Lett. 499 (3): 274–8. doi:10.1016/S0014-5793(01)02556-X. PMID 11423130.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.  
  • Gorski DH, Leal AJ (2003). "Inhibition of endothelial cell activation by the homeobox gene Gax.". J. Surg. Res. 111 (1): 91–9. doi:10.1016/S0022-4804(03)00042-8. PMID 12842453.  
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Wu Z, Guo H, Chow N, et al. (2005). "Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease.". Nat. Med. 11 (9): 959–65. doi:10.1038/nm1287. PMID 16116430.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Lin J, Friesen MT, Bocangel P, et al. (2006). "Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10.". Mol. Cell. Biochem. 275 (1-2): 75–84. doi:10.1007/s11010-005-0823-3. PMID 16335786.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  
  • Chen Y, Leal AD, Patel S, Gorski DH (2007). "The homeobox gene GAX activates p21WAF1/CIP1 expression in vascular endothelial cells through direct interaction with upstream AT-rich sequences.". J. Biol. Chem. 282 (1): 507–17. doi:10.1074/jbc.M606604200. PMID 17074759.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message