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Myeloid/lymphoid or mixed-lineage leukemia 2
Symbols MLL2; ALR; AAD10
External IDs OMIM602113 MGI2682319 HomoloGene86893 GeneCards: MLL2 Gene
RNA expression pattern
PBB GE MLL2 211790 s at tn.png
PBB GE MLL2 216845 x at tn.png
More reference expression data
Species Human Mouse
Entrez 8085 381022
Ensembl ENSG00000167548 n/a
UniProt O14686 n/a
RefSeq (mRNA) NM_003482 XM_619357
RefSeq (protein) NP_003473 XP_619357
Location (UCSC) Chr 12:
47.7 - 47.74 Mb
PubMed search [1] [2]

Histone-lysine N-methyltransferase MLL2 is an enzyme that in humans is encoded by the MLL2 gene.[1][2] This is a Trithorax-group protein


  1. ^ Prasad R, Zhadanov AB, Sedkov Y, Bullrich F, Druck T, Rallapalli R, Yano T, Alder H, Croce CM, Huebner K, Mazo A, Canaani E (Aug 1997). "Structure and expression pattern of human ALR, a novel gene with strong homology to ALL-1 involved in acute leukemia and to Drosophila trithorax". Oncogene 15 (5): 549-60. doi:10.1038/sj.onc.1201211. PMID 9247308.  
  2. ^ "Entrez Gene: MLL2 myeloid/lymphoid or mixed-lineage leukemia 2".  

Further reading

  • Jiang JX, Deprez RH, Zwarthoff EC, Riegman PH (1996). "Characterization of four novel CAG repeat-containing cDNAs.". Genomics 30 (1): 91–3. doi:10.1006/geno.1995.0015. PMID 8595911.  
  • Imbert G, Saudou F, Yvert G, et al. (1996). "Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats.". Nat. Genet. 14 (3): 285–91. doi:10.1038/ng1196-285. PMID 8896557.  
  • Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMID 10737800.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Goo YH, Sohn YC, Kim DH, et al. (2003). "Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.". Mol. Cell. Biol. 23 (1): 140–9. doi:10.1128/MCB.23.1.140-149.2003. PMID 12482968.  
  • Hughes CM, Rozenblatt-Rosen O, Milne TA, et al. (2004). "Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus.". Mol. Cell 13 (4): 587–97. doi:10.1016/S1097-2765(04)00081-4. PMID 14992727.  
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.  
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.  
  • Mo R, Rao SM, Zhu YJ (2006). "Identification of the MLL2 complex as a coactivator for estrogen receptor alpha.". J. Biol. Chem. 281 (23): 15714–20. doi:10.1074/jbc.M513245200. PMID 16603732.  
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.  
  • Issaeva I, Zonis Y, Rozovskaia T, et al. (2007). "Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth.". Mol. Cell. Biol. 27 (5): 1889–903. doi:10.1128/MCB.01506-06. PMID 17178841.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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