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Myeloid/lymphoid or mixed-lineage leukemia 3
Identifiers
Symbols MLL3; DKFZp686C08112; FLJ12625; FLJ38309; HALR; KIAA1506; MGC119851; MGC119852; MGC119853
External IDs OMIM606833 MGI2444959 HomoloGene46480 GeneCards: MLL3 Gene
Orthologs
Species Human Mouse
Entrez 58508 231051
Ensembl n/a ENSMUSG00000038056
UniProt n/a Q3TU00
RefSeq (mRNA) NM_021230 XM_001002522
RefSeq (protein) NP_067053 XP_001002522
Location (UCSC) n/a Chr 5:
24.78 - 25.01 Mb
PubMed search [1] [2]

Histone-lysine N-methyltransferase MLL3 is an enzyme that in humans is encoded by the MLL3 gene.[1][2]

This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a nuclear protein with an AT-hook DNA-binding domain, a DHHC-type zinc finger, six PHD-type zinc fingers, a SET domain, a post-SET domain and a RING-type zinc finger. This protein is a member of the ASC-2/NCOA6 complex (ASCOM), which possesses histone methylation activity and is involved in transcriptional coactivation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2]

Contents

Interactions

MLL3 has been shown to interact with NCOA6[3] and RBBP5.[3]

References

  1. ^ Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 7 (2): 143–50. PMID 10819331.  
  2. ^ a b "Entrez Gene: MLL3 myeloid/lymphoid or mixed-lineage leukemia 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=58508.  
  3. ^ a b Goo, Young-Hwa; Sohn Young Chang, Kim Dae-Hwan, Kim Seung-Whan, Kang Min-Jung, Jung Dong-Ju, Kwak Eunyee, Barlev Nickolai A, Berger Shelley L, Chow Vincent T, Roeder Robert G, Azorsa David O, Meltzer Paul S, Suh Pan-Gil, Song Eun Joo, Lee Kong-Joo, Lee Young Chul, Lee Jae Woon (Jan. 2003). "Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins". Mol. Cell. Biol. (United States) 23 (1): 140–9. ISSN 0270-7306. PMID 12482968.  

Further reading

  • Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.  
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  
  • "Toward a complete human genome sequence.". Genome Res. 8 (11): 1097–108. 1999. PMID 9847074.  
  • Tan YC, Chow VT (2002). "Novel human HALR (MLL3) gene encodes a protein homologous to ALR and to ALL-1 involved in leukemia, and maps to chromosome 7q36 associated with leukemia and developmental defects.". Cancer Detect. Prev. 25 (5): 454–69. PMID 11718452.  
  • Ruault M, Brun ME, Ventura M, et al. (2002). "MLL3, a new human member of the TRX/MLL gene family, maps to 7q36, a chromosome region frequently deleted in myeloid leukaemia.". Gene 284 (1-2): 73–81. doi:10.1016/S0378-1119(02)00392-X. PMID 11891048.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Goo YH, Sohn YC, Kim DH, et al. (2003). "Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.". Mol. Cell. Biol. 23 (1): 140–9. doi:10.1128/MCB.23.1.140-149.2003. PMID 12482968.  
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.  
  • Fukuda K, Sakakura C, Miyagawa K, et al. (2004). "Differential gene expression profiles of radioresistant oesophageal cancer cell lines established by continuous fractionated irradiation.". Br. J. Cancer 91 (8): 1543–50. doi:10.1038/sj.bjc.6602187. PMID 15365572.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  
  • Kim SC, Sprung R, Chen Y, et al. (2006). "Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.". Mol. Cell 23 (4): 607–18. doi:10.1016/j.molcel.2006.06.026. PMID 16916647.  
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.  
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.  
  • Cho YW, Hong T, Hong S, et al. (2007). "PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.". J. Biol. Chem. 282 (28): 20395–406. doi:10.1074/jbc.M701574200. PMID 17500065.  
  • Ahn CH, Yoo NJ, Lee JW, et al. (2007). "Absence of MLL3 mutations in colorectal carcinomas of Korean patients.". APMIS 115 (7): 859–60. doi:10.1111/j.1600-0463.2007.apm_696.x. PMID 17614854.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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