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Myeloid/lymphoid or mixed-lineage leukemia 4
Symbols MLL4; MLL2; HRX2; KIAA0304; TRX2; WBP7
External IDs OMIM606834 MGI109565 HomoloGene22838 GeneCards: MLL4 Gene
RNA expression pattern
PBB GE MLL4 203419 at tn.png
PBB GE MLL4 217075 x at tn.png
More reference expression data
Species Human Mouse
Entrez 9757 75410
Ensembl ENSG00000105663 ENSMUSG00000006307
UniProt Q9UMN6 Q6P6H8
RefSeq (mRNA) NM_014727 NM_029274
RefSeq (protein) NP_055542 NP_083550
Location (UCSC) Chr 19:
40.9 - 40.92 Mb
Chr 7:
30.28 - 30.3 Mb
PubMed search [1] [2]

Myeloid/lymphoid or mixed-lineage leukemia 4, also known as MLL4, is a human gene.[1]

This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene, however, the full length nature of the shorter transcript is not known.[1]


Further reading

  • Bedford MT, Chan DC, Leder P (1997). "FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands.". EMBO J. 16 (9): 2376–83. doi:10.1093/emboj/16.9.2376. PMID 9171351.  
  • Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.  
  • FitzGerald KT, Diaz MO (1999). "MLL2: A new mammalian member of the trx/MLL family of genes.". Genomics 59 (2): 187–92. doi:10.1006/geno.1999.5860. PMID 10409430.  
  • Huntsman DG, Chin SF, Muleris M, et al. (2000). "MLL2, the second human homolog of the Drosophila trithorax gene, maps to 19q13.1 and is amplified in solid tumor cell lines.". Oncogene 18 (56): 7975–84. doi:10.1038/sj.onc.1203291. PMID 10637508.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.  
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.  
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.  
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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