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MLLT1: Wikis


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Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
Symbols MLLT1; ENL; LTG19; YEATS1
External IDs OMIM159556 MGI1927238 HomoloGene4339 GeneCards: MLLT1 Gene
RNA expression pattern
PBB GE MLLT1 214477 at tn.png
PBB GE MLLT1 gnf1h01846 at tn.png
More reference expression data
Species Human Mouse
Entrez 4298 64144
Ensembl ENSG00000130382 ENSMUSG00000024212
UniProt Q03111 n/a
RefSeq (mRNA) NM_005934 XM_974773
RefSeq (protein) NP_005925 XP_979867
Location (UCSC) Chr 19:
6.16 - 6.23 Mb
Chr 17:
56.58 - 56.62 Mb
PubMed search [1] [2]

Protein ENL is a protein that in humans is encoded by the MLLT1 gene.[1]



MLLT1 has been shown to interact with CBX8.[2]


  1. ^ "Entrez Gene: MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1".  
  2. ^ García-Cuéllar, M P; Zilles O, Schreiner S A, Birke M, Winkler T H, Slany R K (Jan. 2001). "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3". Oncogene (England) 20 (4): 411–9. doi:10.1038/sj.onc.1204108. ISSN 0950-9232. PMID 11313972.  

Further reading

  • Tkachuk DC, Kohler S, Cleary ML (1992). "Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias.". Cell 71 (4): 691–700. PMID 1423624.  
  • Thirman MJ, Levitan DA, Kobayashi H, et al. (1995). "Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia.". Proc. Natl. Acad. Sci. U.S.A. 91 (25): 12110–4. PMID 7991593.  
  • Rubnitz JE, Morrissey J, Savage PA, Cleary ML (1994). "ENL, the gene fused with HRX in t(11;19) leukemias, encodes a nuclear protein with transcriptional activation potential in lymphoid and myeloid cells.". Blood 84 (6): 1747–52. PMID 8080983.  
  • Yamamoto K, Seto M, Komatsu H, et al. (1993). "Two distinct portions of LTG19/ENL at 19p13 are involved in t(11;19) leukemia.". Oncogene 8 (10): 2617–25. PMID 8378076.  
  • Lavau C, Luo RT, Du C, Thirman MJ (2000). "Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice.". Proc. Natl. Acad. Sci. U.S.A. 97 (20): 10984–9. doi:10.1073/pnas.190167297. PMID 10995463.  
  • García-Cuéllar MP, Zilles O, Schreiner SA, et al. (2001). "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3.". Oncogene 20 (4): 411–9. doi:10.1038/sj.onc.1204108. PMID 11313972.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Nie Z, Yan Z, Chen EH, et al. (2003). "Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner.". Mol. Cell. Biol. 23 (8): 2942–52. PMID 12665591.  
  • Gué M, Sun JS, Boudier T (2006). "Simultaneous localization of MLL, AF4 and ENL genes in interphase nuclei by 3D-FISH: MLL translocation revisited.". BMC Cancer 6: 20. doi:10.1186/1471-2407-6-20. PMID 16433901.  
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.  
  • Meyer C, Burmeister T, Strehl S, et al. (2007). "Spliced MLL fusions: a novel mechanism to generate functional chimeric MLL-MLLT1 transcripts in t(11;19)(q23;p13.3) leukemia.". Leukemia 21 (3): 588–90. doi:10.1038/sj.leu.2404542. PMID 17252016.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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