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MLX (gene): Wikis


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MAX-like protein X
Symbols MLX; MAD7; MXD7; TCFL4
External IDs OMIM602976 MGI108398 HomoloGene7969 GeneCards: MLX Gene
RNA expression pattern
PBB GE MLX 213708 s at tn.png
PBB GE MLX 210752 s at tn.png
PBB GE MLX 217909 s at tn.png
More reference expression data
Species Human Mouse
Entrez 6945 21428
Ensembl ENSG00000108788 ENSMUSG00000017801
UniProt Q9UH92 Q3UQB4
RefSeq (mRNA) NM_170607 NM_011550
RefSeq (protein) NP_733752 NP_035680
Location (UCSC) Chr 17:
37.97 - 37.98 Mb
Chr 11:
100.9 - 100.91 Mb
PubMed search [1] [2]

Max-like protein X is a protein that in humans is encoded by the MLX gene.[1][2]

The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[2]



MLX (gene) has been shown to interact with MNT,[3][4] MXD1[3][4] and MLXIPL.[3]


  1. ^ Bjerknes M, Cheng H (Jan 1997). "TCFL4: a gene at 17q21.1 encoding a putative basic helix-loop-helix leucine-zipper transcription factor". Gene 181 (1-2): 7–11. PMID 8973301.  
  2. ^ a b "Entrez Gene: MLX MAX-like protein X".  
  3. ^ a b c Cairo, S; Merla G, Urbinati F, Ballabio A, Reymond A (Mar. 2001). "WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network". Hum. Mol. Genet. (England) 10 (6): 617–27. ISSN 0964-6906. PMID 11230181.  
  4. ^ a b Meroni, G; Cairo S, Merla G, Messali S, Brent R, Ballabio A, Reymond A (Jul. 2000). "Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?". Oncogene (ENGLAND) 19 (29): 3266–77. doi:10.1038/sj.onc.1203634. ISSN 0950-9232. PMID 10918583.  

Further reading

  • Rommens JM, Durocher F, McArthur J, et al. (1996). "Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21.". Genomics 28 (3): 530–42. doi:10.1006/geno.1995.1185. PMID 7490091.  
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  
  • Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.  
  • Billin AN, Eilers AL, Queva C, Ayer DE (2000). "Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors.". J. Biol. Chem. 274 (51): 36344–50. doi:10.1074/jbc.274.51.36344. PMID 10593926.  
  • Meroni G, Cairo S, Merla G, et al. (2000). "Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?". Oncogene 19 (29): 3266–77. doi:10.1038/sj.onc.1203634. PMID 10918583.  
  • Billin AN, Eilers AL, Coulter KL, et al. (2000). "MondoA, a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network.". Mol. Cell. Biol. 20 (23): 8845–54. doi:10.1128/MCB.20.23.8845-8854.2000. PMID 11073985.  
  • Cairo S, Merla G, Urbinati F, et al. (2001). "WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network.". Hum. Mol. Genet. 10 (6): 617–27. doi:10.1093/hmg/10.6.617. PMID 11230181.  
  • Eilers AL, Sundwall E, Lin M, et al. (2003). "A novel heterodimerization domain, CRM1, and 14-3-3 control subcellular localization of the MondoA-Mlx heterocomplex.". Mol. Cell. Biol. 22 (24): 8514–26. doi:10.1128/MCB.22.24.8514-8526.2002. PMID 12446771.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Merla G, Howald C, Antonarakis SE, Reymond A (2005). "The subcellular localization of the ChoRE-binding protein, encoded by the Williams-Beuren syndrome critical region gene 14, is regulated by 14-3-3.". Hum. Mol. Genet. 13 (14): 1505–14. doi:10.1093/hmg/ddh163. PMID 15163635.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Ma L, Tsatsos NG, Towle HC (2005). "Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes.". J. Biol. Chem. 280 (12): 12019–27. doi:10.1074/jbc.M413063200. PMID 15664996.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Sans CL, Satterwhite DJ, Stoltzman CA, et al. (2006). "MondoA-Mlx heterodimers are candidate sensors of cellular energy status: mitochondrial localization and direct regulation of glycolysis.". Mol. Cell. Biol. 26 (13): 4863–71. doi:10.1128/MCB.00657-05. PMID 16782875.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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