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Myeloid cell nuclear differentiation antigen

PDB rendering based on 2dbg.
Available structures
Symbols MNDA; PYHIN3
External IDs OMIM159553 HomoloGene74438 GeneCards: MNDA Gene
RNA expression pattern
PBB GE MNDA 204959 at tn.png
More reference expression data
Species Human Mouse
Entrez 4332 n/a
Ensembl ENSG00000163563 n/a
UniProt P41218 n/a
RefSeq (mRNA) NM_002432 n/a
RefSeq (protein) NP_002423 n/a
Location (UCSC) Chr 1:
157.07 - 157.09 Mb
PubMed search [1] n/a

Myeloid cell nuclear differentiation antigen is a protein that in humans is encoded by the MNDA gene.[1][2][3]

The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons.[3]


  1. ^ Briggs JA, Burrus GR, Stickney BD, Briggs RC (Sep 1992). "Cloning and expression of the human myeloid cell nuclear differentiation antigen: regulation by interferon alpha". J Cell Biochem 49 (1): 82-92. doi:10.1002/jcb.240490114. PMID 1644857.  
  2. ^ Briggs RC, Briggs JA, Ozer J, Sealy L, Dworkin LL, Kingsmore SF, Seldin MF, Kaur GP, Athwal RS, Dessypris EN (May 1994). "The human myeloid cell nuclear differentiation antigen gene is one of at least two related interferon-inducible genes located on chromosome 1q that are expressed specifically in hematopoietic cells". Blood 83 (8): 2153-62. PMID 7512843.  
  3. ^ a b "Entrez Gene: MNDA myeloid cell nuclear differentiation antigen".  

Further reading

  • Burrus GR, Briggs JA, Briggs RC (1992). "Characterization of the human myeloid cell nuclear differentiation antigen: relationship to interferon-inducible proteins.". J. Cell. Biochem. 48 (2): 190–202. doi:10.1002/jcb.240480210. PMID 1377701.  
  • Ott J, Fràter-Schröder M (1982). "Absence of linkage between transcobalamin II and ABO.". Hum. Genet. 59 (2): 164–5. doi:10.1007/BF00293068. PMID 7327575.  
  • Dawson MJ, Trapani JA, Briggs RC, et al. (1995). "The closely linked genes encoding the myeloid nuclear differentiation antigen (MNDA) and IFI16 exhibit contrasting haemopoietic expression.". Immunogenetics 41 (1): 40–3. doi:10.1007/BF00188431. PMID 7806273.  
  • Briggs R, Dworkin L, Briggs J, et al. (1994). "Interferon alpha selectively affects expression of the human myeloid cell nuclear differentiation antigen in late stage cells in the monocytic but not the granulocytic lineage.". J. Cell. Biochem. 54 (2): 198–206. doi:10.1002/jcb.240540208. PMID 8175894.  
  • Xie J, Briggs JA, Briggs RC (1998). "Human hematopoietic cell specific nuclear protein MNDA interacts with the multifunctional transcription factor YY1 and stimulates YY1 DNA binding.". J. Cell. Biochem. 70 (4): 489–506. doi:10.1002/(SICI)1097-4644(19980915)70:4<489::AID-JCB6>3.0.CO;2-F. PMID 9712147.  
  • Doggett KL, Briggs JA, Linton MF, et al. (2002). "Retroviral mediated expression of the human myeloid nuclear antigen in a null cell line upregulates Dlk1 expression.". J. Cell. Biochem. 86 (1): 56–66. doi:10.1002/jcb.10190. PMID 12112016.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Fukushi M, Higuchi M, Oie M, et al. (2004). "Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus interacts with human myeloid cell nuclear differentiation antigen induced by interferon alpha.". Virus Genes 27 (3): 237–47. doi:10.1023/A:1026391715071. PMID 14618084.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Briggs RC, Atkinson JB, Miranda RN (2005). "Variable expression of human myeloid specific nuclear antigen MNDA in monocyte lineage cells in atherosclerosis.". J. Cell. Biochem. 95 (2): 293–301. doi:10.1002/jcb.20435. PMID 15778972.  
  • Asefa B, Dermott JM, Kaldis P, et al. (2006). "p205, a potential tumor suppressor, inhibits cell proliferation via multiple pathways of cell cycle regulation.". FEBS Lett. 580 (5): 1205–14. doi:10.1016/j.febslet.2006.01.032. PMID 16458891.  
  • Briggs RC, Shults KE, Flye LA, et al. (2006). "Dysregulated human myeloid nuclear differentiation antigen expression in myelodysplastic syndromes: evidence for a role in apoptosis.". Cancer Res. 66 (9): 4645–51. doi:10.1158/0008-5472.CAN-06-0229. PMID 16651415.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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