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MAX binding protein
Identifiers
Symbols MNT; MAD6; MXD6; ROX
External IDs OMIM603039 MGI109150 HomoloGene7842 GeneCards: MNT Gene
RNA expression pattern
PBB GE MNT 204206 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4335 17428
Ensembl ENSG00000070444 ENSMUSG00000000282
UniProt Q99583 Q3UGG9
RefSeq (mRNA) NM_020310 NM_010813
RefSeq (protein) NP_064706 NP_034943
Location (UCSC) Chr 17:
2.23 - 2.25 Mb
Chr 11:
74.65 - 74.66 Mb
PubMed search [1] [2]

Max-binding protein MNT is a protein that in humans is encoded by the MNT gene.[1][2]

The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain.[2]

Contents

Interactions

MNT (gene) has been shown to interact with MLX,[3][4] SIN3A[5] and MAX.[5]

References

  1. ^ Lo Nigro C, Venesio T, Reymond A, Meroni G, Alberici P, Cainarca S, Enrico F, Stack M, Ledbetter DH, Liscia DS, Ballabio A, Carrozzo R (Aug 1998). "The human ROX gene: genomic structure and mutation analysis in human breast tumors". Genomics 49 (2): 275–82. doi:10.1006/geno.1998.5241. PMID 9598315.  
  2. ^ a b "Entrez Gene: MNT MAX binding protein". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4335.  
  3. ^ Cairo, S; Merla G, Urbinati F, Ballabio A, Reymond A (Mar. 2001). "WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network". Hum. Mol. Genet. (England) 10 (6): 617–27. ISSN 0964-6906. PMID 11230181.  
  4. ^ Meroni, G; Cairo S, Merla G, Messali S, Brent R, Ballabio A, Reymond A (Jul. 2000). "Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?". Oncogene (ENGLAND) 19 (29): 3266–77. doi:10.1038/sj.onc.1203634. ISSN 0950-9232. PMID 10918583.  
  5. ^ a b Meroni, G; Reymond A, Alcalay M, Borsani G, Tanigami A, Tonlorenzi R, Lo Nigro C, Messali S, Zollo M, Ledbetter D H, Brent R, Ballabio A, Carrozzo R (May. 1997). "Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor". EMBO J. (ENGLAND) 16 (10): 2892–906. doi:10.1093/emboj/16.10.2892. ISSN 0261-4189. PMID 9184233.  

Further reading

  • Meroni G, Reymond A, Alcalay M, et al. (1997). "Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor.". EMBO J. 16 (10): 2892–906. doi:10.1093/emboj/16.10.2892. PMID 9184233.  
  • Hirotsune S, Pack SD, Chong SS, et al. (1997). "Genomic organization of the murine Miller-Dieker/lissencephaly region: conservation of linkage with the human region.". Genome Res. 7 (6): 625–34. PMID 9199935.  
  • Meroni G, Cairo S, Merla G, et al. (2000). "Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?". Oncogene 19 (29): 3266–77. doi:10.1038/sj.onc.1203634. PMID 10918583.  
  • Cairo S, Merla G, Urbinati F, et al. (2001). "WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network.". Hum. Mol. Genet. 10 (6): 617–27. PMID 11230181.  
  • Stoneley M, Spencer JP, Wright SC (2001). "An internal ribosome entry segment in the 5' untranslated region of the mnt gene.". Oncogene 20 (7): 893–7. doi:10.1038/sj.onc.1204157. PMID 11314024.  
  • Dintilhac A, Bernués J (2002). "HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences.". J. Biol. Chem. 277 (9): 7021–8. doi:10.1074/jbc.M108417200. PMID 11748221.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.  
  • Smith AG, Popov N, Imreh M, et al. (2005). "Expression and DNA-binding activity of MYCN/Max and Mnt/Max during induced differentiation of human neuroblastoma cells.". J. Cell. Biochem. 92 (6): 1282–95. doi:10.1002/jcb.20121. PMID 15258910.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer.". Mamm. Genome 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.  
  • Guo XL, Pan L, Zhang XJ, et al. (2007). "Expression and mutation analysis of genes that encode the Myc antagonists Mad1, Mxi1 and Rox in acute leukaemia.". Leuk. Lymphoma 48 (6): 1200–7. doi:10.1080/10428190701342018. PMID 17577784.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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