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Homeobox HB9
Symbols MNX1;HLXB9; HB9; HOXHB9; SCRA1
External IDs OMIM142994 MGI109160 HomoloGene21137 GeneCards: MNX1 Gene
RNA expression pattern
PBB GE HLXB9 214614 at tn.png
More reference expression data
Species Human Mouse
Entrez 3110 15285
Ensembl ENSG00000130675 ENSMUSG00000001566
UniProt P50219 Q9QZW9
RefSeq (mRNA) NM_005515 NM_019944
RefSeq (protein) NP_005506 NP_064328
Location (UCSC) Chr 7:
156.49 - 156.5 Mb
Chr 5:
29.8 - 29.81 Mb
PubMed search [1] [2]

Motor neuron and pancreas homeobox 1 (MNX1) also known as Homeobox HB9 (HLXB9), is a human gene.[1]


Further reading

  • Catala M (2002). "Genetic control of caudal development.". Clin. Genet. 61 (2): 89–96. doi:10.1034/j.1399-0004.2002.610202.x. PMID 11940082.  
  • Deguchi Y, Kehrl JH (1991). "Nucleotide sequence of a novel diverged human homeobox gene encodes a DNA binding protein.". Nucleic Acids Res. 19 (13): 3742. doi:10.1093/nar/19.13.3742. PMID 1677181.  
  • Deguchi Y, Kehrl JH (1991). "Selective expression of two homeobox genes in CD34-positive cells from human bone marrow.". Blood 78 (2): 323–8. PMID 1712647.  
  • Lynch SA, Bond PM, Copp AJ, et al. (1995). "A gene for autosomal dominant sacral agenesis maps to the holoprosencephaly region at 7q36.". Nat. Genet. 11 (1): 93–5. doi:10.1038/ng0995-93. PMID 7550324.  
  • Harrison KA, Druey KM, Deguchi Y, et al. (1994). "A novel human homeobox gene distantly related to proboscipedia is expressed in lymphoid and pancreatic tissues.". J. Biol. Chem. 269 (31): 19968–75. PMID 7914194.  
  • Ross AJ, Ruiz-Perez V, Wang Y, et al. (1998). "A homeobox gene, HLXB9, is the major locus for dominantly inherited sacral agenesis.". Nat. Genet. 20 (4): 358–61. doi:10.1038/3828. PMID 9843207.  
  • Heus HC, Hing A, van Baren MJ, et al. (1999). "A physical and transcriptional map of the preaxial polydactyly locus on chromosome 7q36.". Genomics 57 (3): 342–51. doi:10.1006/geno.1999.5796. PMID 10329000.  
  • Belloni E, Martucciello G, Verderio D, et al. (2000). "Involvement of the HLXB9 homeobox gene in Currarino syndrome.". Am. J. Hum. Genet. 66 (1): 312–9. doi:10.1086/302723. PMID 10631160.  
  • Hagan DM, Ross AJ, Strachan T, et al. (2000). "Mutation analysis and embryonic expression of the HLXB9 Currarino syndrome gene.". Am. J. Hum. Genet. 66 (5): 1504–15. doi:10.1086/302899. PMID 10749657.  
  • Köchling J, Karbasiyan M, Reis A (2001). "Spectrum of mutations and genotype-phenotype analysis in Currarino syndrome.". Eur. J. Hum. Genet. 9 (8): 599–605. doi:10.1038/sj.ejhg.5200683. PMID 11528505.  
  • Nagel S, Scherr M, Quentmeier H, et al. (2005). "HLXB9 activates IL6 in Hodgkin lymphoma cell lines and is regulated by PI3K signalling involving E2F3.". Leukemia 19 (5): 841–6. doi:10.1038/sj.leu.2403716. PMID 15772702.  
  • Cheng J, Kapranov P, Drenkow J, et al. (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution.". Science 308 (5725): 1149–54. doi:10.1126/science.1108625. PMID 15790807.  
  • Hori Y, Gu X, Xie X, Kim SK (2006). "Differentiation of insulin-producing cells from human neural progenitor cells.". PLoS Med. 2 (4): e103. doi:10.1371/journal.pmed.0020103. PMID 15839736.  
  • Kapranov P, Drenkow J, Cheng J, et al. (2005). "Examples of the complex architecture of the human transcriptome revealed by RACE and high-density tiling arrays.". Genome Res. 15 (7): 987–97. doi:10.1101/gr.3455305. PMID 15998911.  
  • von Bergh AR, van Drunen E, van Wering ER, et al. (2006). "High incidence of t(7;12)(q36;p13) in infant AML but not in infant ALL, with a dismal outcome and ectopic expression of HLXB9.". Genes Chromosomes Cancer 45 (8): 731–9. doi:10.1002/gcc.20335. PMID 16646086.  
  • Kim IS, Oh SY, Choi SJ, et al. (2007). "Clinical and genetic analysis of HLXB9 gene in Korean patients with Currarino syndrome.". J. Hum. Genet. 52 (8): 698–701. doi:10.1007/s10038-007-0173-y. PMID 17612791.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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