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MORF4L1: Wikis


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Mortality factor 4 like 1

PDB rendering based on 2aql.
Available structures
2aql, 2f5j, 2f5k
Symbols MORF4L1; Eaf3; FWP006; HsT17725; MGC10631; MORFRG15; MRG15; S863-6
External IDs OMIM607303 MGI1096551 HomoloGene86043 GeneCards: MORF4L1 Gene
Species Human Mouse
Entrez 10933 21761
Ensembl n/a ENSMUSG00000062270
UniProt n/a Q3U5J6
RefSeq (mRNA) NM_006791 NM_001039147
RefSeq (protein) NP_006782 NP_001034236
Location (UCSC) n/a Chr 9:
89.89 - 89.91 Mb
PubMed search [1] [2]

Mortality factor 4-like protein 1 is a protein that in humans is encoded by the MORF4L1 gene.[1][2][3]


MORF4L1 has been shown to interact with MYST1,[4] Retinoblastoma protein[5][4] and MRFAP1.[5][4]


  1. ^ Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.  
  2. ^ Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Jun 1997). "Large-scale concatenation cDNA sequencing". Genome Res 7 (4): 353–8. PMID 9110174.  
  3. ^ "Entrez Gene: MORF4L1 mortality factor 4 like 1".  
  4. ^ a b c Pardo, Patricia S; Leung James K, Lucchesi John C, Pereira-Smith Olivia M (Dec. 2002). "MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation". J. Biol. Chem. (United States) 277 (52): 50860–6. doi:10.1074/jbc.M203839200. ISSN 0021-9258. PMID 12397079.  
  5. ^ a b Leung, J K; Berube N, Venable S, Ahmed S, Timchenko N, Pereira-Smith O M (Oct. 2001). "MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14". J. Biol. Chem. (United States) 276 (42): 39171–8. doi:10.1074/jbc.M103435200. ISSN 0021-9258. PMID 11500496.  

Further reading

  • Doyon Y, Côté J (2004). "The highly conserved and multifunctional NuA4 HAT complex.". Curr. Opin. Genet. Dev. 14 (2): 147–54. doi:10.1016/j.gde.2004.02.009. PMID 15196461.  
  • Pena AN, Pereira-Smith OM (2007). "The role of the MORF/MRG family of genes in cell growth, differentiation, DNA repair, and thereby aging.". Ann. N. Y. Acad. Sci. 1100: 299–305. doi:10.1196/annals.1395.031. PMID 17460191.  
  • Bertram MJ, Bérubé NG, Hang-Swanson X, et al. (1999). "Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes.". Mol. Cell. Biol. 19 (2): 1479–85. PMID 9891081.  
  • Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMID 11042152.  
  • Leung JK, Berube N, Venable S, et al. (2001). "MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14.". J. Biol. Chem. 276 (42): 39171–8. doi:10.1074/jbc.M103435200. PMID 11500496.  
  • Yochum GS, Ayer DE (2002). "Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split.". Mol. Cell. Biol. 22 (22): 7868–76. doi:10.1128/MCB.22.22.7868-7876.2002. PMID 12391155.  
  • Pardo PS, Leung JK, Lucchesi JC, Pereira-Smith OM (2003). "MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation.". J. Biol. Chem. 277 (52): 50860–6. doi:10.1074/jbc.M203839200. PMID 12397079.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Cai Y, Jin J, Tomomori-Sato C, et al. (2003). "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex.". J. Biol. Chem. 278 (44): 42733–6. doi:10.1074/jbc.C300389200. PMID 12963728.  
  • Tominaga K, Leung JK, Rookard P, et al. (2004). "MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner.". J. Biol. Chem. 278 (49): 49618–24. doi:10.1074/jbc.M309192200. PMID 14506250.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Doyon Y, Selleck W, Lane WS, et al. (2004). "Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans.". Mol. Cell. Biol. 24 (5): 1884–96. doi:10.1128/MCB.24.5.1884-1896.2004. PMID 14966270.  
  • Tominaga K, Magee DM, Matzuk MM, Pereira-Smith OM (2004). "PAM14, a novel MRG- and Rb-associated protein, is not required for development and T-cell function in mice.". Mol. Cell. Biol. 24 (19): 8366–73. doi:10.1128/MCB.24.19.8366-8373.2004. PMID 15367658.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression.". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMID 15498874.  
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.  
  • Cai Y, Jin J, Florens L, et al. (2005). "The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes.". J. Biol. Chem. 280 (14): 13665–70. doi:10.1074/jbc.M500001200. PMID 15647280.  


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