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Metastasis associated 1 family, member 3

PDB rendering based on 2crg.
Available structures
Symbols MTA3; KIAA1266
External IDs OMIM609050 MGI2151172 HomoloGene14282 GeneCards: MTA3 Gene
Species Human Mouse
Entrez 57504 116871
Ensembl ENSG00000057935 ENSMUSG00000055817
UniProt Q9BTC8 Q3U3A7
RefSeq (mRNA) NM_020744 NM_054082
RefSeq (protein) NP_065795 NP_473423
Location (UCSC) Chr 2:
42.65 - 42.84 Mb
Chr 17:
83.61 - 83.73 Mb
PubMed search [1] [2]

Metastasis-associated protein MTA3 is a protein that in humans is encoded by the MTA3 gene.[1][2][3]


  1. ^ Fujita N, Jaye DL, Kajita M, Geigerman C, Moreno CS, Wade PA (Apr 2003). "MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer". Cell 113 (2): 207-19. PMID 12705869.  
  2. ^ Kumar R, Wang RA, Bagheri-Yarmand R (Nov 2003). "Emerging roles of MTA family members in human cancers". Semin Oncol 30 (5 Suppl 16): 30-7. PMID 14613024.  
  3. ^ "Entrez Gene: MTA3 metastasis associated 1 family, member 3".  

Further reading

  • Wade PA, Gegonne A, Jones PL, et al. (1999). "Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation.". Nat. Genet. 23 (1): 62–6. doi:10.1038/12664. PMID 10471500.  
  • Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.  
  • Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome.". Science 291 (5507): 1304–51. doi:10.1126/science.1058040. PMID 11181995.  
  • Simpson A, Uitto J, Rodeck U, Mahoney MG (2001). "Differential expression and subcellular distribution of the mouse metastasis-associated proteins Mta1 and Mta3.". Gene 273 (1): 29–39. doi:10.1016/S0378-1119(01)00563-7. PMID 11483358.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Yao YL, Yang WM (2004). "The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity.". J. Biol. Chem. 278 (43): 42560–8. doi:10.1074/jbc.M302955200. PMID 12920132.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Mishra SK, Talukder AH, Gururaj AE, et al. (2004). "Upstream determinants of estrogen receptor-alpha regulation of metastatic tumor antigen 3 pathway.". J. Biol. Chem. 279 (31): 32709–15. doi:10.1074/jbc.M402942200. PMID 15169784.  
  • Fujita N, Kajita M, Taysavang P, Wade PA (2005). "Hormonal regulation of metastasis-associated protein 3 transcription in breast cancer cells.". Mol. Endocrinol. 18 (12): 2937–49. doi:10.1210/me.2004-0258. PMID 15358836.  
  • Fujita N, Jaye DL, Geigerman C, et al. (2004). "MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation.". Cell 119 (1): 75–86. doi:10.1016/j.cell.2004.09.014. PMID 15454082.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Zhang H, Singh RR, Talukder AH, Kumar R (2006). "Metastatic tumor antigen 3 is a direct corepressor of the Wnt4 pathway.". Genes Dev. 20 (21): 2943–8. doi:10.1101/gad.1461706. PMID 17050676.  

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