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From Wikipedia, the free encyclopedia

Metal-regulatory transcription factor 1
Symbols MTF1; MGC23036; MTF-1; ZRF
External IDs OMIM600172 MGI101786 HomoloGene4347 GeneCards: MTF1 Gene
RNA expression pattern
PBB GE MTF1 205323 s at tn.png
PBB GE MTF1 205322 s at tn.png
More reference expression data
Species Human Mouse
Entrez 4520 17764
Ensembl ENSG00000188786 ENSMUSG00000028890
UniProt Q14872 Q80W60
RefSeq (mRNA) NM_005955 XM_622562
RefSeq (protein) NP_005946 XP_622562
Location (UCSC) Chr 1:
38.05 - 38.1 Mb
Chr 4:
124.3 - 124.35 Mb
PubMed search [1] [2]

Metal regulatory transcription factor 1 is a protein that in humans is encoded by the MTF1 gene.[1][2]

This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE).[2]


Further reading

  • Westin G, Schaffner W (1989). "A zinc-responsive factor interacts with a metal-regulated enhancer element (MRE) of the mouse metallothionein-I gene.". Embo J. 7 (12): 3763–70. PMID 3208749.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Chen X, Chu M, Giedroc DP (1999). "MRE-Binding transcription factor-1: weak zinc-binding finger domains 5 and 6 modulate the structure, affinity, and specificity of the metal-response element complex.". Biochemistry 38 (39): 12915–25. doi:10.1021/bi9913000. PMID 10504263.  
  • Otsuka F, Okugaito I, Ohsawa M, et al. (2000). "Novel responses of ZRF, a variant of human MTF-1, to in vivo treatment with heavy metals.". Biochim. Biophys. Acta 1492 (2-3): 330–40. PMID 11004505.  
  • Saydam N, Georgiev O, Nakano MY, et al. (2001). "Nucleo-cytoplasmic trafficking of metal-regulatory transcription factor 1 is regulated by diverse stress signals.". J. Biol. Chem. 276 (27): 25487–95. doi:10.1074/jbc.M009154200. PMID 11306562.  
  • Saydam N, Adams TK, Steiner F, et al. (2002). "Regulation of metallothionein transcription by the metal-responsive transcription factor MTF-1: identification of signal transduction cascades that control metal-inducible transcription.". J. Biol. Chem. 277 (23): 20438–45. doi:10.1074/jbc.M110631200. PMID 11923282.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Majumder S, Ghoshal K, Summers D, et al. (2003). "Chromium(VI) down-regulates heavy metal-induced metallothionein gene transcription by modifying transactivation potential of the key transcription factor, metal-responsive transcription factor 1.". J. Biol. Chem. 278 (28): 26216–26. doi:10.1074/jbc.M302887200. PMID 12716893.  
  • Saydam N, Steiner F, Georgiev O, Schaffner W (2003). "Heat and heavy metal stress synergize to mediate transcriptional hyperactivation by metal-responsive transcription factor MTF-1.". J. Biol. Chem. 278 (34): 31879–83. doi:10.1074/jbc.M302138200. PMID 12805380.  
  • Chen X, Zhang B, Harmon PM, et al. (2004). "A novel cysteine cluster in human metal-responsive transcription factor 1 is required for heavy metal-induced transcriptional activation in vivo.". J. Biol. Chem. 279 (6): 4515–22. doi:10.1074/jbc.M308924200. PMID 14610091.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Balamurugan K, Egli D, Selvaraj A, et al. (2005). "Metal-responsive transcription factor (MTF-1) and heavy metal stress response in Drosophila and mammalian cells: a functional comparison.". Biol. Chem. 385 (7): 597–603. doi:10.1515/BC.2004.074. PMID 15318808.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Joshi B, Ordonez-Ercan D, Dasgupta P, Chellappan S (2005). "Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors.". Oncogene 24 (13): 2204–17. doi:10.1038/sj.onc.1208206. PMID 15735762.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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