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Mucin 1, cell surface associated

PDB rendering based on 2acm.
Available structures
2acm
Identifiers
Symbols MUC1; EMA; CD227; H23AG; MAM6; PEM; PEMT; PUM
External IDs OMIM158340 MGI97231 HomoloGene8416 GeneCards: MUC1 Gene
RNA expression pattern
PBB GE MUC1 207847 s at tn.png
PBB GE MUC1 211695 x at tn.png
PBB GE MUC1 213693 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4582 17829
Ensembl ENSG00000185499 ENSMUSG00000042784
UniProt P15941 Q99K60
RefSeq (mRNA) NM_001018021 NM_013605
RefSeq (protein) NP_001018021 NP_038633
Location (UCSC) Chr 1:
153.39 - 153.43 Mb
Chr 3:
89.31 - 89.32 Mb
PubMed search [1] [2]

Mucin 1, cell surface associated, also known as MUC1, is a protein which in humans is encoded by the MUC1 gene.[1] Mucin proteins penetrate the membranes of epithelial cells, on the inner surface of the intestine and other organs. Mucin protects the body from infection by binding to pathogens. Overexpression of the mucin protein is often associated with colon and many other cancers.[2]

Contents

Function

This gene is a member of the mucin family and encodes a membrane bound, glycosylated phosphoprotein. The protein is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type. It also includes a 20 amino acid variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length nature of only some has been determined.[3]

Interactions

MUC1 has been shown to interact with Beta-catenin,[4][5][6][7][8][9][10] HER2/neu,[11][12] Epidermal growth factor receptor,[12][10] Plakoglobin,[11] LYN,[5] GSK3B,[6][8] Src,[8][10] PRKCD,[9] CTNND1,[13] SOS1[14][12] and Grb2.[14]

See also

References

  1. ^ Gendler SJ, Lancaster CA, Taylor-Papadimitriou J, Duhig T, Peat N, Burchell J, Pemberton L, Lalani EN, Wilson D (September 1990). "Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin". J. Biol. Chem. 265 (25): 15286–93. PMID 1697589.  
  2. ^ Niv Y (April 2008). "MUC1 and colorectal cancer pathophysiology considerations". World J. Gastroenterol. 14 (14): 2139–41. doi:10.3748/wjg.14.2139. PMID 18407586.  
  3. ^ "Entrez Gene: MUC1 mucin 1, cell surface associated". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4582.  
  4. ^ Yamamoto, M; Bharti A, Li Y, Kufe D (May. 1997). "Interaction of the DF3/MUC1 breast carcinoma-associated antigen and beta-catenin in cell adhesion". J. Biol. Chem. (UNITED STATES) 272 (19): 12492–4. doi:10.1074/jbc.272.19.12492. ISSN 0021-9258. PMID 9139698.  
  5. ^ a b Li, Yongqing; Chen Wen, Ren Jian, Yu Wei-Hsuan, Li Quan, Yoshida Kiyotsugu, Kufe Donald (2003). "DF3/MUC1 signaling in multiple myeloma cells is regulated by interleukin-7". Cancer Biol. Ther. (United States) 2 (2): 187–93. ISSN 1538-4047. PMID 12750561.  
  6. ^ a b Li, Y; Bharti A, Chen D, Gong J, Kufe D (Dec. 1998). "Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin". Mol. Cell. Biol. (UNITED STATES) 18 (12): 7216–24. ISSN 0270-7306. PMID 9819408.  
  7. ^ Schroeder, Joyce A; Adriance Melissa C, Thompson Melissa C, Camenisch Todd D, Gendler Sandra J (Mar. 2003). "MUC1 alters beta-catenin-dependent tumor formation and promotes cellular invasion". Oncogene (England) 22 (9): 1324–32. doi:10.1038/sj.onc.1206291. ISSN 0950-9232. PMID 12618757.  
  8. ^ a b c Li, Y; Kuwahara H, Ren J, Wen G, Kufe D (Mar. 2001). "The c-Src tyrosine kinase regulates signaling of the human DF3/MUC1 carcinoma-associated antigen with GSK3 beta and beta-catenin". J. Biol. Chem. (United States) 276 (9): 6061–4. doi:10.1074/jbc.C000754200. ISSN 0021-9258. PMID 11152665.  
  9. ^ a b Ren, Jian; Li Yongqing, Kufe Donald (May. 2002). "Protein kinase C delta regulates function of the DF3/MUC1 carcinoma antigen in beta-catenin signaling". J. Biol. Chem. (United States) 277 (20): 17616–22. doi:10.1074/jbc.M200436200. ISSN 0021-9258. PMID 11877440.  
  10. ^ a b c Li, Y; Ren J, Yu W, Li Q, Kuwahara H, Yin L, Carraway K L, Kufe D (Sep. 2001). "The epidermal growth factor receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src and beta-catenin". J. Biol. Chem. (United States) 276 (38): 35239–42. doi:10.1074/jbc.C100359200. ISSN 0021-9258. PMID 11483589.  
  11. ^ a b Li, Yongqing; Yu Wei-Hsuan, Ren Jian, Chen Wen, Huang Lei, Kharbanda Surender, Loda Massimo, Kufe Donald (Aug. 2003). "Heregulin targets gamma-catenin to the nucleolus by a mechanism dependent on the DF3/MUC1 oncoprotein". Mol. Cancer Res. (United States) 1 (10): 765–75. ISSN 1541-7786. PMID 12939402.  
  12. ^ a b c Schroeder, J A; Thompson M C, Gardner M M, Gendler S J (Apr. 2001). "Transgenic MUC1 interacts with epidermal growth factor receptor and correlates with mitogen-activated protein kinase activation in the mouse mammary gland". J. Biol. Chem. (United States) 276 (16): 13057–64. doi:10.1074/jbc.M011248200. ISSN 0021-9258. PMID 11278868.  
  13. ^ Li, Y; Kufe D (Feb. 2001). "The Human DF3/MUC1 carcinoma-associated antigen signals nuclear localization of the catenin p120(ctn)". Biochem. Biophys. Res. Commun. (United States) 281 (2): 440–3. doi:10.1006/bbrc.2001.4383. ISSN 0006-291X. PMID 11181067.  
  14. ^ a b Pandey, P; Kharbanda S, Kufe D (Sep. 1995). "Association of the DF3/MUC1 breast cancer antigen with Grb2 and the Sos/Ras exchange protein". Cancer Res. (UNITED STATES) 55 (18): 4000–3. ISSN 0008-5472. PMID 7664271.  

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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