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myosin, heavy chain 13, skeletal muscle
Symbol MYH13
External IDs OMIM603487 MGI1339967 HomoloGene55780 GeneCards: MYH13 Gene
Species Human Mouse
Entrez 8735 544791
Ensembl ENSG00000006788 ENSMUSG00000060180
UniProt Q9UKX3 B1AR69
RefSeq (mRNA) NM_003802 NM_001081250
RefSeq (protein) NP_003793 NP_001074719
Location (UCSC) Chr 17:
10.13 - 10.22 Mb
Chr 11:
67.14 - 67.19 Mb
PubMed search [1] [2]

Myosin-13 also known as myosin, heavy chain 13 is a protein which in humans is encoded by the MYH13 gene.[1]


MYH13 is a myosin whose expression is restricted primarily to the extrinsic eye muscles which are specialized for function in eye movement.[2]


  1. ^ Winters LM, Briggs MM, Schachat F (November 1998). "The human extraocular muscle myosin heavy chain gene (MYH13) maps to the cluster of fast and developmental myosin genes on chromosome 17". Genomics 54 (1): 188–9. doi:10.1006/geno.1998.5558. PMID 9806854. 
  2. ^ Weiss A, Schiaffino S, Leinwand LA (July 1999). "Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity". J. Mol. Biol. 290 (1): 61–75. doi:10.1006/jmbi.1999.2865. PMID 10388558. 

Further reading

  • Weiss A, McDonough D, Wertman B, et al. (1999). "Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved.". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2958-63. PMID 10077619. 
  • Schachat F, Briggs MM (2002). "Phylogenetic implications of the superfast myosin in extraocular muscles.". J. Exp. Biol. 205 (Pt 15): 2189-201. PMID 12110653. 
  • Trynka G, Zhernakova A, Romanos J, et al. (2009). "Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.". Gut 58 (8): 1078-83. doi:10.1136/gut.2008.169052. PMID 19240061. 
  • Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315-23. doi:10.1101/gr.2122004. PMID 15231747. 
  • Schjeide BM, McQueen MB, Mullin K, et al. (2009). "Assessment of Alzheimer's disease case-control associations using family-based methods.". Neurogenetics 10 (1): 19-25. doi:10.1007/s10048-008-0151-3. PMID 18830724. 
  • Shoeman RL, Sachse C, Höner B, et al. (1993). "Cleavage of human and mouse cytoskeletal and sarcomeric proteins by human immunodeficiency virus type 1 protease. Actin, desmin, myosin, and tropomyosin.". Am. J. Pathol. 142 (1): 221-30. PMID 8424456. 


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