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Myosin IA
Identifiers
Symbols MYO1A; MIHC; BBMI; DFNA48; MYHL
External IDs OMIM601478 MGI107732 HomoloGene21113 GeneCards: MYO1A Gene
RNA expression pattern
PBB GE MYO1A 211916 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4640 432516
Ensembl ENSG00000166866 ENSMUSG00000025401
UniProt Q9UBC5 n/a
RefSeq (mRNA) NM_005379 XM_001005647
RefSeq (protein) NP_005370 XP_001005647
Location (UCSC) Chr 12:
55.71 - 55.73 Mb
Chr 10:
127.11 - 127.12 Mb
PubMed search [1] [2]

Myosin-Ia is a protein that in humans is encoded by the MYO1A gene.[1][2][3]

The protein encoded by this gene belongs to the myosin superfamily. Myosins are molecular motors that, upon interaction with actin filaments, utilize energy from ATP hydrolysis to generate mechanical force. Each myosin has a conserved N-terminal motor domain that contains both ATP-binding and actin-binding sequences. Following the motor domain is a light-chain-binding 'neck' region containing 1-6 copies of a repeat element, the IQ motif, that serves as a binding site for calmodulin or other members of the EF-hand superfamily of calcium-binding proteins. At the C-terminus, each myosin class has a distinct tail domain that serves in dimerization, membrane binding, protein binding, and/or enzymatic activities and targets each myosin to its particular subcellular location. The myosin-1a protein is expressed by enterocytes, the epithelial cells that line the luminal surface of the small intestine. In these cells the myosin-1a protein localizes specifically to the brush border. Experiments indicate that the brush border population of the encoded protein turns over rapidly, while its head and tail domains interact transiently with the core actin and plasma membrane, respectively. A rapidly exchanging pool of the myosin-1a protein binds to the actin core bundle, which turns over on a much slower timescale.[4]

References

  1. ^ Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, Anderson BL, Sherr EH, Chen ZY, Greene LA, Ward DC, Corey DP, Mooseker MS, Copeland NG, Jenkins NA (Feb 1997). "Mapping of unconventional myosins in mouse and human". Genomics 36 (3): 431-9. doi:10.1006/geno.1996.0488. PMID 8884266.  
  2. ^ Donaudy F, Ferrara A, Esposito L, Hertzano R, Ben-David O, Bell RE, Melchionda S, Zelante L, Avraham KB, Gasparini P (May 2003). "Multiple mutations of MYO1A, a cochlear-expressed gene, in sensorineural hearing loss". Am J Hum Genet 72 (6): 1571-7. doi:10.1086/375654. PMID 12736868.  
  3. ^ "Entrez Gene: MYO1A myosin IA". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4640.  
  4. ^ Tyska MJ, Mooseker MS (April 2002). "MYO1A (brush border myosin I) dynamics in the brush border of LLC-PK1-CL4 cells". Biophys. J. 82 (4): 1869–83. doi:10.1016/S0006-3495(02)75537-9. PMID 11916846. PMC 1301984. http://www.biophysj.org/cgi/content/abstract/82/4/1869.  

Further reading

  • Hofmann WA, Johnson T, Klapczynski M, et al. (2007). "From transcription to transport: emerging roles for nuclear myosin I.". Biochem. Cell Biol. 84 (4): 418–26. doi:10.1139/o06-069. PMID 16936815.  
  • Hoshimaru M, Fujio Y, Sobue K, et al. (1990). "Immunochemical evidence that myosin I heavy chain-like protein is identical to the 110-kilodalton brush-border protein.". J. Biochem. 106 (3): 455–9. PMID 2606897.  
  • Bement WM, Hasson T, Wirth JA, et al. (1994). "Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types.". Proc. Natl. Acad. Sci. U.S.A. 91 (14): 6549–53. doi:10.1073/pnas.91.14.6549. PMID 8022818.  
  • Durrbach A, Collins K, Matsudaira P, et al. (1996). "Brush border myosin-I truncated in the motor domain impairs the distribution and the function of endocytic compartments in an hepatoma cell line.". Proc. Natl. Acad. Sci. U.S.A. 93 (14): 7053–8. doi:10.1073/pnas.93.14.7053. PMID 8692943.  
  • Skowron JF, Bement WM, Mooseker MS (1999). "Human brush border myosin-I and myosin-Ic expression in human intestine and Caco-2BBe cells.". Cell Motil. Cytoskeleton 41 (4): 308–24. doi:10.1002/(SICI)1097-0169(1998)41:4<308::AID-CM4>3.0.CO;2-J. PMID 9858156.  
  • Li W, Wang J, Coluccio LM, et al. (2000). "Brush border myosin I (BBMI): a basally localized transcript in human jejunal enterocytes.". J. Histochem. Cytochem. 48 (1): 89–94. PMID 10653589.  
  • Otterbein LR, Graceffa P, Dominguez R (2001). "The crystal structure of uncomplexed actin in the ADP state.". Science 293 (5530): 708–11. doi:10.1126/science.1059700. PMID 11474115.  
  • Tyska MJ, Mooseker MS (2002). "MYO1A (brush border myosin I) dynamics in the brush border of LLC-PK1-CL4 cells.". Biophys. J. 82 (4): 1869–83. doi:10.1016/S0006-3495(02)75537-9. PMID 11916846.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • D'Adamo P, Pinna M, Capobianco S, et al. (2003). "A novel autosomal dominant non-syndromic deafness locus (DFNA48) maps to 12q13-q14 in a large Italian family.". Hum. Genet. 112 (3): 319–20. doi:10.1007/s00439-002-0880-6. PMID 12596055.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
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