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Myelin transcription factor 1
Symbols MYT1; MTF1; C20orf36; MYTI; PLPB1
External IDs OMIM600379 MGI1100535 HomoloGene3332 GeneCards: MYT1 Gene
RNA expression pattern
PBB GE MYT1 210341 at tn.png
PBB GE MYT1 215822 x at tn.png
More reference expression data
Species Human Mouse
Entrez 4661 17932
Ensembl ENSG00000196132 ENSMUSG00000010505
UniProt Q01538 Q3UXY0
RefSeq (mRNA) NM_004535 NM_008665
RefSeq (protein) NP_004526 NP_032691
Location (UCSC) Chr 20:
62.25 - 62.34 Mb
Chr 2:
181.72 - 181.76 Mb
PubMed search [1] [2]

Myelin transcription factor 1 is a protein that in humans is encoded by the MYT1 gene.[1][2][3]

The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system.[3]



MYT1 has been shown to interact with PIN1.[4]


  1. ^ Kim JG, Hudson LD (Dec 1992). "Novel member of the zinc finger superfamily: A C2-HC finger that recognizes a glia-specific gene". Mol Cell Biol 12 (12): 5632–9. PMID 1280325.  
  2. ^ Booher RN, Holman PS, Fattaey A (Oct 1997). "Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity". J Biol Chem 272 (35): 22300–6. PMID 9268380.  
  3. ^ a b "Entrez Gene: MYT1 myelin transcription factor 1".  
  4. ^ Wells, N J; Watanabe N, Tokusumi T, Jiang W, Verdecia M A, Hunter T (Oct. 1999). "The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M progression". J. Cell. Sci. (ENGLAND) 112 ( Pt 19): 3361–71. ISSN 0021-9533. PMID 10504341.  

Further reading

  • Gogate N, Verma L, Zhou JM, et al. (1994). "Plasticity in the adult human oligodendrocyte lineage.". J. Neurosci. 14 (8): 4571–87. PMID 7519254.  
  • Armstrong RC, Kim JG, Hudson LD (1996). "Expression of myelin transcription factor I (MyTI), a "zinc-finger" DNA-binding protein, in developing oligodendrocytes.". Glia 14 (4): 303–21. doi:10.1002/glia.440140407. PMID 8530187.  
  • Liu F, Stanton JJ, Wu Z, Piwnica-Worms H (1997). "The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex.". Mol. Cell. Biol. 17 (2): 571–83. PMID 9001210.  
  • Kim JG, Armstrong RC, v Agoston D, et al. (1998). "Myelin transcription factor 1 (Myt1) of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system.". J. Neurosci. Res. 50 (2): 272–90. doi:10.1002/(SICI)1097-4547(19971015)50:2<272::AID-JNR16>3.0.CO;2-A. PMID 9373037.  
  • Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.  
  • Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.  
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Hirayama A, Oka A, Ito M, et al. (2003). "Myelin transcription factor 1 (MyT1) immunoreactivity in infants with periventricular leukomalacia.". Brain Res. Dev. Brain Res. 140 (1): 85–92. doi:10.1016/S0165-3806(02)00585-0. PMID 12524179.  
  • Nielsen JA, Berndt JA, Hudson LD, Armstrong RC (2004). "Myelin transcription factor 1 (Myt1) modulates the proliferation and differentiation of oligodendrocyte lineage cells.". Mol. Cell. Neurosci. 25 (1): 111–23. doi:10.1016/j.mcn.2003.10.001. PMID 14962745.  
  • Vana AC, Lucchinetti CF, Le TQ, Armstrong RC (2007). "Myelin transcription factor 1 (Myt1) expression in demyelinated lesions of rodent and human CNS.". Glia 55 (7): 687–97. doi:10.1002/glia.20492. PMID 17330875.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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