From Wikipedia, the free encyclopedia
Malaoxon is a breakdown product of malathion. It is more toxic
than malathion.
Air
& Water Reactions
This chemical may be sensitive to prolonged exposure to air.
(NTP, 1992). Slightly water soluble.
Fire
Hazard
This chemical is probably combustible. (NTP, 1992)
Health
Hazard
Symptoms of exposure to this type of compound include
cholinesterase inhibition, miosis, frontal headache, increased
bronchial secretion, nausea, vomiting, sweating, abdominal cramps,
diarrhea, lacrimation, increased salivation, bradycardia, cyanosis
and muscular twitching of the eyelids, tongue, face and neck,
possibly progressing to convulsions. Other symptoms include
hyperemia of the conjunctiva, dimness of vision, rhinorrhea,
bronchoconstriction, cough, fasciculation, anorexia, incontinence,
eye changes, weakness, dyspnea, bronchospasm, hypotension or
hypertension due to asphyxia, restlessness, anxiety, dizziness,
drowsiness, tremor, ataxia, depression, confusion, neuropathy
(rare), coma and death from depression of respiratory or
cardiovascular systems. Exposure to this type of compound may
result in giddiness, nervousness, blurred vision, discomfort
(tightness) in chest, papilledema, muscular weakness, loss of
reflexes, loss of sphincter control, cardiac arrhythmias, various
degrees of heart block and cardiac arrest. It may also result in
spasm of accommodation, aching pain in and about the eye,
nystagmus, delayed distal axonopathy and parethesias and paralysis
of limbs. A decrease in blood pressure may occur. Respiratory
failure may also occur.
Acute/Chronic Hazards
This compound is toxic by ingestion. It is a CHOLINESTERASE
INHIBITOR. When heated to decomposition it emits toxic fumes of
sulfur oxides and phosphorus oxides. (NTP, 1992)
Reactivity
Profile
A thioorganophosphate, ester. Organophosphates are susceptible
to formation of highly toxic and flammable phosphine gas in the
presence of strong reducing agents such as hydrides. Partial
oxidation by oxidizing agents may result in the release of toxic
phosphorus oxides. Esters react with acids to liberate heat along
with alcohols and acids. Strong oxidizing acids may cause a
vigorous reaction that is sufficiently exothermic to ignite the
reaction products. Heat is also generated by the interaction of
esters with caustic solutions. Flammable hydrogen is generated by
mixing esters with alkali metals and hydrides.
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Receptor
Ligands |
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Agonists:
77-LH-28-1 • AC-42 • AC-260,584 • Aceclidine • Acetylcholine • AF30 • AF150(S) • AF267B
• AFDX-384 • Alvameline • AQRA-741 • Arecoline • Bethanechol • Butyrylcholine • Carbachol • CDD-0034 • CDD-0078 • CDD-0097 •
CDD-0098 • CDD-0102 • Cevimeline • cis-Dioxolane •
Ethoxysebacylcholine • LY-593,039 • L-689,660 • LY-2,033,298 •
McNA343 • Methacholine • Milameline • Muscarine • NGX-267 • Ocvimeline • Oxotremorine •
PD-151,832 • Pilocarpine • RS86 • Sabcomeline • SDZ 210-086 • Sebacylcholine
• Suberylcholine • Talsaclidine • Thiopilocarpine • Vedaclidine •
VU-0029767 • VU-0090157 • VU-0152099 • VU-0152100 • VU-0238429 •
WAY-132,983 • Xanomeline • YM-796
Antagonists: 3-Quinuclidinyl Benzilate •
4-DAMP • Atropine •
Atropine Methonitrate • Benactyzine • Benzatropine (Benztropine) • Benzydamine • BIBN 99 •
Biperiden • Bornaprine • CAR-226,086 • CAR-301,060 • CAR-302,196 •
CAR-302,282 • CAR-302,368 • CAR-302,537 • CAR-302,668 • CS-27349 •
Cyclobenzaprine • Cyclopentolate •
Darifenacin •
DAU-5884 • Dimethindene • Dexetimide • DIBD • Dicyclomine
(Dicycloverine) • Ditran • EA-3167 • EA-3443 • EA-3580 • EA-3834 • Elemicin • Etanautine • Etybenzatropine (Ethylbenztropine) • Flavoxate • Himbacine • HL-031,120 • Ipratropium • J-104,129
• Hyoscyamine • Mamba Toxin 3 • Mamba Toxin 7 • Mazaticol • Mebeverine • Methoctramine • Metixene • Myristicin • N-Ethyl-3-Piperidyl
Benzilate • N-Methyl-3-Piperidyl
Benzilate • Orphenadrine • Otenzepad • Oxybutynin • PBID •
PD-102,807 • Phenglutarimide • Phenyltoloxamine • Pirenzepine • Piroheptine • Procyclidine • Profenamine • RU-47,213
• SCH-57,790 • SCH-72,788 • SCH-217,443 • Scopolamine (Hyoscine) • Solifenacin • Telenzepine • Tiotropium • Tolterodine • Trihexyphenidyl
• Tripitamine • Tropatepine • Tropicamide • WIN-2299 • Zamifenacin;
Others: 1st
Generation Antihistamines ( Brompheniramine • Chlorpheniramine, Cyclizine, Cyproheptadine, Dimenhydrinate,
Diphenhydramine, Doxylamine, Hydroxyzine, Meclizine, Mepyramine/ Pyrilamine, Phenindamine, Pheniramine, Tripelennamine,
Triprolidine, etc)
• Tricyclic Antidepressants ( Amitriptyline, Doxepin, Trimipramine, etc) •
Tetracyclic Antidepressants
( Amoxapine, Maprotiline, etc) • Typical
Antipsychotics ( Chlorpromazine, Thioridazine, etc) • Atypical Antipsychotics ( Clozapine, Olanzapine, Quetiapine, etc)
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Agonists: 5-HIAA • A-84,543 • A-366,833 • A-582,941 • A-867,744 • ABT-202 • ABT-418 • ABT-560 • ABT-894 • Acetylcholine • Altinicline • Anabasine • AR-R17779 • Butyrylcholine •
Carbachol • Cotinine • Cytisine • Decamethonium • Desformylflustrabromine • Dianicline • Dimethylphenylpiperazinium •
Epibatidine • Epiboxidine •
Ethoxysebacylcholine • EVP-4473 • EVP-6124 • Galantamine • GTS-21 • Ispronicline • Lobeline • MEM-63,908 (RG-3487) • Nicotine • NS-1738 • PHA-543,613 •
PHA-709,829 • PNU-120,596 • PNU-282,987 • Pozanicline • Rivanicline • Sazetidine A • Sebacylcholine • SIB-1508Y
• SIB-1553A • SSR-180,711 • Suberylcholine • TC-1698 • TC-1734 • TC-1827 •
TC-2216 • TC-5214 • TC-5619 • TC-6683 • Tebanicline • Tropisetron • UB-165 • Varenicline • XY-4083
Antagonists: 18-Methoxycoronaridine • α-Bungarotoxin • α-Conotoxin • Alcuronium • Anatruxonium • Atracurium • Bupropion (Amfebutamone) •
Chandonium • Chlorisondamine • Cisatracurium •
Coclaurine • Coronaridine • Dacuronium • Decamethonium • Dextromethorphan • Dextropropoxyphene • Dextrorphan • Diadonium
• DHβE • Dimethyltubocurarine (Metocurine) •
Dipyrandium • Dizocilpine (MK-801) • Doxacurium • Duador • Esketamine • Fazadinium • Gallamine • Hexafluronium • Hexamethonium (Benzohexonium) • Ibogaine • Ketamine • Kynurenic Acid •
Levacetylmethadol • Malouetine • Mecamylamine • Memantine • Methadone • Methorphan
(Racemethorphan) • Methyllycaconitine • Metocurine • Mivacurium • Morphanol (Racemorphanol) •
Neramexane • Pancuronium • Pempidine • Pentamine • Pentolinium • Phencyclidine • Pipecuronium • Radafaxine • Rapacuronium • Rocuronium • Surugatoxin • Suxamethonium
(Succinylcholine) • Toxiferine • Trimethaphan •
Tropeinium • Tubocurarine • Vecuronium
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Reuptake
Inhibitors |
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Enzyme
Inhibitors |
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1-(-Benzoylethyl)pyridinium •
2-(α-Naphthoyl)ethyltrimethylammonium • 3-Chloro-4-stillbazole •
4-(1-Naphthylvinyl)pyridine • Acetylseco Hemicholinium-3 •
Acryloylcholine • AF64A • B115 • BETA • CM-54,903 •
N,N-Dimethylaminoethylacrylate •
N,N-Dimethylaminoethylchloroacetate
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Many of the
acetylcholinesterase inhibitors listed above act as
butyrylcholinesterase inhibitors.
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Others |
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