From Wikipedia, the free encyclopedia
Mandragora officinarum is a species of Mandragora
(mandrake), which is used medicinally.
Physical Characteristics
Perennial growing to 0.1m by 0.3m . It is hardy to zone 7
and is not frost tender. It is in leaf from March to July, in
flower from March to April, and the seeds ripen from July to
August. The flowers are hermaphrodite (have both male and female
organs) and are pollinated by Insects. The plant is self-fertile.
We rate it 1 out of 5 for usefulness.
The plant prefers light (sandy) and medium (loamy) soils and
requires well-drained soil. The plant prefers acid and neutral
soils. It can grow in semi-shade (light woodland) or no shade. It
requires dry or moist soil.
Habitats and Possible
Locations
Woodland, Cultivated Beds, Sunny Edge, Dappled Shade.
Edible Uses
Fruit
Fruit - raw or cooked. A delicacy[89]. The fruit is about
the size of a small apple, with a strong apple-like scent[4].
Caution is advised in the use of this fruit, it is quite possibly
poisonous[K].
Medicinal
Uses
Disclaimer Cathartic; Emetic; Hallucinogenic;
Narcotic.
Mandrake has a long history of medicinal use, though
superstition has played a large part in the uses it has been
applied to. It is rarely prescribed in modern herbalism[238],
though it contains hyoscine which is the standard pre-operative
medication given to soothe patients and reduce bronchial
secretions[244]. It is also used to treat travel sickness[244].
The fresh or dried root contains highly poisonous alkaloids and
is cathartic, strongly emetic, hallucinogenic and narcotic[4, 21,
46, 192, 244]. In sufficient quantities it induces a state of
oblivion and was used as an anaesthetic for operations in early
surgery[238]. It was much used in the past for its anodyne and
soporific properties[4]. In the past, juice from the finely grated
root was applied externally to relieve rheumatic pains, ulcers and
scrofulous tumours[244]. It was also used internally to treat
melancholy, convulsions and mania[244]. When taken internally in
large doses, however, it is said to excite delirium and madness[4].
The root should be used with caution, and only under the
supervision of a qualified practitioner[21, 238]. See the notes
above on toxicity.
The leaves are harmless and cooling. They have been used for
ointments and other external applications to ulcers etc[4].
Other
Uses
None known
Cultivation
details
Prefers a deep humus-rich light soil and a sheltered
position in full sun[238]. It also tolerates some shade[200].
Prefers a circumneutral soil[200] and dislikes chalk or gravel[4].
Plants are liable to rot in wet or ill-draining soils[4].
Plants are hardy to about -15°c[187].
The roots are somewhat carrot-shaped and can be up to 1.2 metres
long[4]. Plants are intolerant of root disturbance and should be
put out into their permanent positions as soon as
possible[188].
The root often divides into two and is vaguely suggestive of the
human body. In the past it was frequently made into amulets which
were believed to bring good fortune, cure sterility etc[244]. There
is a superstition that if a person pulls up this root they will be
condemned to hell[244]. Therefore in the past people have tied the
roots to the bodies of animals and then used these animals in order
to pull the roots out of the soil.
Propagation
Seed - best sown in a cold frame in the autumn[188]. The
seed can also be sown in spring in a cold frame. When they are
large enough to handle, prick the seedlings out into individual
pots and grow them on in the greenhouse for at least their first
winter. Plant them out into their permanent positions in late
spring or early summer, after the last expected frosts.
Root cuttings in winter[200].
Division
This can be rather difficult since the plants resent root
disturbance."
References
| Hallucinogens |
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Psychedelics
5-HT2AR Agonists |
Lysergamides: AL-LAD • ALD-52 • BU-LAD • CYP-LAD • DAM-57 • Diallyllysergamide • Ergometrine
(Ergonovine, Ergobasine) • ETH-LAD • LAE-32 • LSA (Ergine,
Lysergamide) • LSD • LSH • LPD-824 • LSM-775 • Lysergic Acid 2-Butyl
Amide|LSB • Lysergic Acid
2,4-Dimethylazetidide • Methylergometrine • Methylisopropyllysergamide •
Methysergide • MLD-41 • PARGY-LAD • PRO-LAD;
Phenethylamines: Aleph •
2C-B • 2C-B-FLY • 2CBFly-NBOMe • 2C-C • 2C-D • 2C-E • 2C-F • 2C-G • 2C-I • 2C-N • 2C-O • 2C-O-4 • 2C-P • 2C-T • 2C-T-2 • 2C-T-4 • 2C-T-7 • 2C-T-8 • 2C-T-9 • 2C-T-13 • 2C-T-15 • 2C-T-17 • 2C-T-21 • 2C-TFM • 2C-YN • 2CBCB-NBOMe • 25B-NBOMe • 25I-NBMD • 25I-NBOH • 25I-NBOMe • 3C-E • 3C-P • Br-DFLY • DESOXY • DMMDA-2 • DOB • DOC • DOEF • DOET • DOF • DOI
• DOM • DON • DOPR • DOTFM • Escaline • Ganesha • HOT-2 • HOT-7
• HOT-17 • Isoproscaline • Jimscaline • Lophophine • MDA •
MDEA • MDMA
• MMDA • MMDA-2 • MMDA-3a • MMDMA • Macromerine • Mescaline • Methallylescaline • Proscaline • TCB-2 • TFMFly • TMA;
Piperazines: pFPP •
TMFPP;
Tryptamines: 1-Methyl-5-methoxy-diisopropyltryptamine
• 2,N,N-TMT •
4,N,N-TMT • 4-HO-5-MeO-DMT •
4-Acetoxy-DET •
4-Acetoxy-DIPT
• 4-Acetoxy-DMT • 4-Acetoxy-DPT •
4-Acetoxy-MiPT • 4-HO-DPT
• 4-HO-MET •
4-Propionyloxy-DMT •
4-Hydroxy-N-Methyl-(a,N-trimethylene)tryptamine •
5-Me-MIPT • 5-N,N-TMT
• 5-AcO-DMT • 5-MeO-2,N,N-TMT •
5-MeO-4,N,N-TMT • 5-MeO-a,N,N-TMT • 5-MeO-a-ET • 5-MeO-a-MT • 5-MeO-DALT • 5-MeO-DET • 5-MeO-DIPT • 5-MeO-DMT • 5-MeO-DPT • 5-MeO-EiPT •
5-MeO-MET • 5-MeO-MIPT •
5-Methoxy-N-methyl-(a,N-trimethylene)tryptamine •
7,N,N-TMT • a,N,N-TMT • a-ET • a-MT • AL-37350A • Baeocystin • Bufotenin • DBT • DET • DIPT • DMT • DPT • EiPT • Ethocin • Ethocybin • Iprocin • MET
• Miprocin • MIPT
• Norbaeocystin
• PiPT • Psilocin • Psilocybin;
Others: AL-38022A • Ibogaine • Noribogaine • Voacangine
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Dissociatives
NMDAR
Antagonists |
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Deliriants
mAChR Antagonists |
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Miscellaneous
Atypicals |
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| Cholinergics |
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Receptor
Ligands |
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Agonists:
77-LH-28-1 • AC-42 • AC-260,584 • Aceclidine • Acetylcholine • AF30 • AF150(S) • AF267B
• AFDX-384 • Alvameline • AQRA-741 • Arecoline • Bethanechol • Butyrylcholine • Carbachol • CDD-0034 • CDD-0078 • CDD-0097 •
CDD-0098 • CDD-0102 • Cevimeline • cis-Dioxolane •
Ethoxysebacylcholine • LY-593,039 • L-689,660 • LY-2,033,298 •
McNA343 • Methacholine • Milameline • Muscarine • NGX-267 • Ocvimeline • Oxotremorine •
PD-151,832 • Pilocarpine • RS86 • Sabcomeline • SDZ 210-086 • Sebacylcholine
• Suberylcholine • Talsaclidine • Thiopilocarpine • Vedaclidine •
VU-0029767 • VU-0090157 • VU-0152099 • VU-0152100 • VU-0238429 •
WAY-132,983 • Xanomeline • YM-796
Antagonists: 3-Quinuclidinyl Benzilate •
4-DAMP • Atropine •
Atropine Methonitrate • Benactyzine • Benzatropine (Benztropine) • Benzydamine • BIBN 99 •
Biperiden • Bornaprine • CAR-226,086 • CAR-301,060 • CAR-302,196 •
CAR-302,282 • CAR-302,368 • CAR-302,537 • CAR-302,668 • CS-27349 •
Cyclobenzaprine • Cyclopentolate •
Darifenacin •
DAU-5884 • Dimethindene • Dexetimide • DIBD • Dicyclomine
(Dicycloverine) • Ditran • EA-3167 • EA-3443 • EA-3580 • EA-3834 • Elemicin • Etanautine • Etybenzatropine (Ethylbenztropine) • Flavoxate • Himbacine • HL-031,120 • Ipratropium • J-104,129
• Hyoscyamine • Mamba Toxin 3 • Mamba Toxin 7 • Mazaticol • Mebeverine • Methoctramine • Metixene • Myristicin • N-Ethyl-3-Piperidyl
Benzilate • N-Methyl-3-Piperidyl
Benzilate • Orphenadrine • Otenzepad • Oxybutynin • PBID •
PD-102,807 • Phenglutarimide • Phenyltoloxamine • Pirenzepine • Piroheptine • Procyclidine • Profenamine • RU-47,213
• SCH-57,790 • SCH-72,788 • SCH-217,443 • Scopolamine (Hyoscine) • Solifenacin • Telenzepine • Tiotropium • Tolterodine • Trihexyphenidyl
• Tripitamine • Tropatepine • Tropicamide • WIN-2299 • Zamifenacin;
Others: 1st
Generation Antihistamines ( Brompheniramine • Chlorpheniramine, Cyclizine, Cyproheptadine, Dimenhydrinate,
Diphenhydramine, Doxylamine, Hydroxyzine, Meclizine, Mepyramine/ Pyrilamine, Phenindamine, Pheniramine, Tripelennamine,
Triprolidine, etc)
• Tricyclic Antidepressants ( Amitriptyline, Doxepin, Trimipramine, etc) •
Tetracyclic Antidepressants
( Amoxapine, Maprotiline, etc) • Typical
Antipsychotics ( Chlorpromazine, Thioridazine, etc) • Atypical Antipsychotics ( Clozapine, Olanzapine, Quetiapine, etc)
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Agonists: 5-HIAA • A-84,543 • A-366,833 • A-582,941 • A-867,744 • ABT-202 • ABT-418 • ABT-560 • ABT-894 • Acetylcholine • Altinicline • Anabasine • AR-R17779 • Butyrylcholine •
Carbachol • Cotinine • Cytisine • Decamethonium • Desformylflustrabromine • Dianicline • Dimethylphenylpiperazinium •
Epibatidine • Epiboxidine •
Ethoxysebacylcholine • EVP-4473 • EVP-6124 • Galantamine • GTS-21 • Ispronicline • Lobeline • MEM-63,908 (RG-3487) • Nicotine • NS-1738 • PHA-543,613 •
PHA-709,829 • PNU-120,596 • PNU-282,987 • Pozanicline • Rivanicline • Sazetidine A • Sebacylcholine • SIB-1508Y
• SIB-1553A • SSR-180,711 • Suberylcholine • TC-1698 • TC-1734 • TC-1827 •
TC-2216 • TC-5214 • TC-5619 • TC-6683 • Tebanicline • Tropisetron • UB-165 • Varenicline • XY-4083
Antagonists: 18-Methoxycoronaridine • α-Bungarotoxin • α-Conotoxin • Alcuronium • Anatruxonium • Atracurium • Bupropion (Amfebutamone) •
Chandonium • Chlorisondamine • Cisatracurium •
Coclaurine • Coronaridine • Dacuronium • Decamethonium • Dextromethorphan • Dextropropoxyphene • Dextrorphan • Diadonium
• DHβE • Dimethyltubocurarine (Metocurine) •
Dipyrandium • Dizocilpine (MK-801) • Doxacurium • Duador • Esketamine • Fazadinium • Gallamine • Hexafluronium • Hexamethonium (Benzohexonium) • Ibogaine • Ketamine • Kynurenic Acid •
Levacetylmethadol • Malouetine • Mecamylamine • Memantine • Methadone • Methorphan
(Racemethorphan) • Methyllycaconitine • Metocurine • Mivacurium • Morphanol (Racemorphanol) •
Neramexane • Pancuronium • Pempidine • Pentamine • Pentolinium • Phencyclidine • Pipecuronium • Radafaxine • Rapacuronium • Rocuronium • Surugatoxin • Suxamethonium
(Succinylcholine) • Toxiferine • Trimethaphan •
Tropeinium • Tubocurarine • Vecuronium
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Reuptake
Inhibitors |
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Enzyme
Inhibitors |
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1-(-Benzoylethyl)pyridinium •
2-(α-Naphthoyl)ethyltrimethylammonium • 3-Chloro-4-stillbazole •
4-(1-Naphthylvinyl)pyridine • Acetylseco Hemicholinium-3 •
Acryloylcholine • AF64A • B115 • BETA • CM-54,903 •
N,N-Dimethylaminoethylacrylate •
N,N-Dimethylaminoethylchloroacetate
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Many of the
acetylcholinesterase inhibitors listed above act as
butyrylcholinesterase inhibitors.
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Others |
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