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Manidipine
Systematic (IUPAC) name
2-[4-(diphenylmethyl)piperazin-1-yl]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Identifiers
CAS number 89226-50-6 120092-68-4
ATC code C08CA11
PubChem 4008
Chemical data
Formula C 35H38N4O6  
Mol. mass 610.69 g/mol
Physical data
Melt. point 125–128 °C (257–262 °F)
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

History

Manidipine patents were registered at Europe on 1983 and at the United States on 1990 to Takeda Chemical Industries under patent numbers USP 4892875 and EP 94159.

Currently Manidipine is marketed by:

-Greek Pharmaceutical group Chiesi Hellas under the brands Manyper, Artedil, Manivasc and Iperten(formerly sold by Torrex Pharma GmbH, now owned by Chiesi Hellas), in Germany, Greece, France, Austria, Spain, Italy and Brazil.

-Takeda Chemical Industries, under the brands Vascoman, Calslot, and Madiplot, in Italy, Japan, Philippines and Thailand.

Medicinal effects

Manidipine (INN) is a calcium channel blocker (dihydropyridin type). And an antihypertensive[1][2][3][4][5].

References

  1. ^ Cheer, S.M.; McClellan, K. (2001), "Manidipine: A Review of its Use in Hypertension", Drugs 61 (12): 1777, http://drugs.adisonline.com/pt/re/drugs/abstract.00003495-200161120-00010.htm, retrieved 2009-06-20  
  2. ^ McKeage, K.; Scott, L.J. (2004), "Manidipine: A Review of its Use in the Management of Hypertension", Drugs 64 (17): 1923, http://drugs.adisonline.com/pt/re/drugs/abstract.00003495-200464170-00011.htm, retrieved 2009-06-20  
  3. ^ Roca-cusachs, A.; Triposkiadis, F. (2005), "Antihypertensive Effect of Manidipine", Drugs 65: 11, http://drugs.adisonline.com/pt/re/drugs/abstract.00003495-200565002-00003.htm, retrieved 2009-06-20  
  4. ^ Otero, M.L. (2007), "Manidipine-delapril combination in the management of hypertension", Vascular Health and Risk Management 3 (3): 255, http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2293964, retrieved 2009-06-20  
  5. ^ Mizuno, Kenji; Hiroshi Haga, Michihiko Takahashi, Soitsu Fukuchi (1992-08). "Evaluation of manidipine hydrochloride, a new calcium antagonist, in the treatment of hypertensive patients with renal disorders". Current Therapeutic Research 52 (2): 248–253. doi:10.1016/S0011-393X(05)80475-8. http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VS8-4GHBHXV-5&_user=10&_coverDate=08%2F31%2F1992&_rdoc=5&_fmt=high&_orig=browse&_srch=doc-info(%23toc%236256%231992%23999479997%23600363%23FLP%23display%23Volume)&_cdi=6256&_sort=d&_docanchor=&_ct=16&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=4a139e549c7d88da59d7ebdfe6f44be7. Retrieved 2009-06-20.  
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