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Marchiafava-Bignami disease: Wikis


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Marchiafava-Bignami disease
Classification and external resources
ICD-10 G37.1
ICD-9 341.8
DiseasesDB 31494
eMedicine neuro/204
MeSH D054319

Marchiafava-Bignami disease is a progressive neurological disease characterized by corpus callosum demyelination and necrosis and subsequent atrophy.



It was first described in 1903 by the Italian pathologists Amico Bignami and Ettore Marchiafava in an Italian Chianti drinker.[1][2] In this patient, Marchiafava and Bignami noticed that the middle two-thirds of the corpus callosum were necrotic.


It is classically associated with chronic alcoholics and sometimes nutritional deficiencies.

See also

Central pontine myelinolysis


  1. ^ synd/2922 at Who Named It?
  2. ^ E. Marchiafava, A. Bignami. Sopra un' alterazione del corpo calloso osservata da sogetti alcoolisti. Rivista di patologia nervosa e mentale, 1903, 8 (12): 544-549.

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