| Mario Capecchi | |
|---|---|
 |
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| Born |
October 6, 1937 Verona, Italy |
| Nationality | United States |
| Fields | Genetics |
| Institutions | Harvard
School of Medicine University of Utah |
| Alma mater | George School Antioch College, Ohio Harvard University |
| Known for | Knockout mouse |
| Notable awards | Albert
Lasker Award for Basic Medical Research (2001) Wolf Prize in Medicine (2002) Nobel Prize in Physiology or Medicine (2007) |
Mario Renato Capecchi (born 6 October 1937) is an Italian-born American molecular geneticist and a co-winner of the 2007 Nobel Prize in Physiology or Medicine.[1] He is currently Distinguished Professor of Human Genetics and Biology at the University of Utah School of Medicine, which he joined in 1973.
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Mario Capecchi was born in the Italian city of Verona in 1937. His father was Luciano Capecchi,[2] an Italian airman who would be later reported as missing in action while manning an anti-aircraft gun in the Western Desert Campaign,[3] His mother was Lucy Ramberg, an American-born[4] daughter of Impressionist painter Lucy Dodd Ramberg and German archaeologist Walter Ramberg. During World War II, his mother was sent to the Dachau concentration camp[4][5] as punishment for pamphleteering and belonging to an anti-Fascist group.[6] Prior to her arrest[2] she had made contingency plans by selling her belongings and giving the proceeds to a peasant family near Bolzano[3] to provide housing for her son. However, after one year,[7] the money was exhausted and the family was unable to care for him. At four-and-a-half years old he was left to fend for himself on the streets of northern Italy for the next four years,[3] living in various orphanages and roving through towns with groups of other homeless children.[7]
He almost died of malnutrition. His mother, meanwhile, had been freed from Dachau and began a year-long search for him. She finally found him in a hospital bed in Reggio Emilia,[3] ill with a fever and subsisting on a daily bowl of chicory coffee and bread crust. She took him to Rome, where he had his first bath in six years.[7]
In 1946 his uncle, Edward Ramberg,[2] an American physicist at RCA, sent his mother money to return to the United States. He and his mother moved to Pennsylvania to live at an intentional cooperative community called Bryn Gweled,[8] which had been co-founded by his uncle. (Capecchi's other maternal uncle, Walter Ramberg, was also an American physicist who served as the tenth president of the Society for Experimental Stress Analysis.[9]) He graduated from George School, a Quaker boarding school in Bucks County, Pennsylvania, in 1956.
Mario Capecchi received his Bachelor of Science in chemistry and physics in 1961 from Antioch College in Ohio. Capecchi came to MIT as a graduate student intending to study physics and mathematics,[10] but during the course of his studies, he became interested in molecular biology. He subsequently transferred to Harvard to join the lab of James D. Watson, co-discoverer of the structure of DNA.[11] Capecchi received his Ph.D. in biophysics in 1967 from Harvard University, with his doctoral thesis completed under the tutelage of Watson.
Capecchi was a Junior Fellow of the Society of Fellows at Harvard University from 1967 to 1969. In 1969 he became an Assistant Professor in the Department of Biochemistry at Harvard Medical School. He was promoted to Associate Professor in 1971. In 1973 he joined the faculty at the University of Utah. Since 1988 Capecchi has also been an investigator of the Howard Hughes Medical Institute. He is a member of the National Academy of Sciences. He has given a talk for Duke University's Program in Genetics and Genomics as part of their Distinguished Lecturer Series.[12]
After the Nobel committee publicly announced that Capecchi had won the Nobel prize, an Austrian woman named Marlene Bonelli claimed that Capecchi was her long-lost half-brother.[13] In May 2008, Capecchi met with Bonelli, 69, in northern Italy, and confirmed that she was his sister. [14]
Capecchi is particularly well known for his pioneering work in gene targeting of the mouse embryo-derived stem cells. This work was accomplished through the efforts of Martin Evans and Oliver Smithies working on the knockout mice. This work was awarded 2007 Nobel prize for medicine or physiology.
Capecchi has also pursued a systematic analysis of the mouse Hox gene family. This gene family plays a key role in the control of embryonic development in all multicellular animals.
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| File:Mario Capecchi | |
| Born | October 6, 1937 Verona, Italy |
|---|---|
| Field | Genetics |
| Institutions | Harvard School of Medicine Duke University University of Utah |
| Alma mater | George School Antioch College, Ohio Harvard University |
| Known for | Knockout mouse |
| Notable prizes | Albert Lasker Award for Basic Medical Research (2001) Wolf Prize in Medicine (2002) Nobel Prize in Physiology or Medicine (2007) |
Mario Renato Capecchi (born 6 October 1937) is an Italian-born American molecular geneticist who won the 2007 Nobel Prize in Physiology or Medicine along with Sir Martin J. Evans and Oliver Smithies.[1] He is a Distinguished Professor of Human Genetics and Biology at the University of Utah School of Medicine, which he joined in 1973.
Contents |
Mario Capecchi was born in the Italian city of Verona in 1937. His father was called Luciano Capecchi,[2] . Luciano was an Italian airman who would was reported as missing in action while using in an anti-aircraft gun in the Western Desert Campaign,[3] His mother was called Lucy Ramberg. Lucy was an American-born[4] daughter of Impressionist painter Lucy Dodd Ramberg and German archaeologist Walter Ramberg. During World War II, his mother was sent to the Dachau concentration camp[4][5] as punishment for handing out pamphlets and belonging to an anti-Fascist group.[6] Before her arrest[2] she had sold her belongings and gave the money to a poor family near Bolzano[3] to give her son a place to live. After one year,[7] the money was all spent and the family was unable to care for him. At four-and-a-half years old he was left to live on the streets of northern Italy for the next four years,[3] living in various orphanages and roving through towns with groups of other homeless children.[7]
He almost died of hunger. His mother had been freed from Dachau and began a year-long search for him. She finally found him in a hospital bed in Reggio Emilia,[3] ill with a fever and living one bowl of chicory coffee and bread crust each day. She took him to Rome, where he had his first bath in six years.[7]
In 1946 his uncle, Edward Ramberg,[2] an American physicist at RCA, sent his mother money to return to the United States. Mario and his mother moved to Pennsylvania to live at an intentional cooperative community called Bryn Gweled,[8] which had been started by his uncle. (Capecchi's other maternal uncle, Walter Ramberg, was also an American physicist who served as the tenth president of the Society for Experimental Stress Analysis.[9]) Professor Capecchi graduated from George School, a Quaker boarding school in Bucks County, Pennsylvania, in 1956.
Mario Capecchi received his Bachelor of Science in chemistry and physics in 1961 from Antioch College in Ohio. Capecchi came to MIT as a graduate student to study physics and mathematics,[10] but he soon became interested in molecular biology. He moved to Harvard to join the laboratory of James D. Watson, co-discoverer of the shape of DNA.[11] Capecchi received his Ph.D. in biophysics in 1967 from Harvard University, he was taught for his exams by Watson.
Capecchi was a Junior Fellow of the Society of Fellows at Harvard University from 1967 to 1969. In 1969 he became an Assistant Professor in the Department of Biochemistry at Harvard Medical School. He was promoted to Associate Professor in 1971. In 1973 he joined the faculty at the University of Utah. Since 1988 Capecchi has also been an investigator of the Howard Hughes Medical Institute. He is a member of the National Academy of Sciences. He has taught for Duke University's Program in Genetics and Genomics.[12]
After the Nobel committee announced that Capecchi had won the Nobel prize, an Austrian woman named Marlene Bonelli claimed that Capecchi was her long-lost half-brother.[13]
Mario Capecchi is well known for his new work in gene targeting of the mouse embryonic stem cells which helped him study other transgenic technologies such as cloning and genetic changing. This work was finished with the efforts of Martin Evans and Oliver Smithies working on the knockout mice. This work was awarded the 2007 Nobel Prize in Physiology or Medicine.
Dr. Capecchi has also pursued a systematic analysis of the mouse Hox gene family. This gene family is used to control embryonic development in all multicellular animals.
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   | Howard Hughes Medical Institute biography - HHMI Scientist Bio: Mario R. Capecchi, Ph.D. |
| | University of Utah biography - Neuroscience Graduate Program; University of Utah: Faculty: Capecchi |
| | U. scientist Mario Cappechi scores a 'knockout' - U. scientist Mario Cappechi scores a 'knockout' - Salt Lake Tribune |
| | U. scientist Capecchi wins Nobel Prize - Deseret News | U. scientist Capecchi wins Nobel Prize |
| | US, UK Scientists Win Nobel in Medicine - ABC News - ABC News |
| | "Ero un ragazzo di strada mia madre mi ha salvato" - "Ero un ragazzo di strada mia madre mi ha salvato" - Scienza & Tecnologia - Repubblica.it |
| | Edward G. Ramberg Papers - Edward G. Ramberg Papers, American Philosophical Society |
| | Scientist Profile: Mario Capecchi - Mario's Transgenic Technology Knocks Out The Nobel Prize |
| | Interviews with Mario Capecchi from Dolan DNA Learning Center's ''DNA Interactive'' - Use of DNA Analysis in Identification, Health, & Human Origins |
| | Capecchi animation from Dolan DNA Learning Center's ''DNA from the Beginning'' - DNA From The Beginning |
| | From Child on Street to Nobel Laureate - From Child on Street to Nobel Laureate |
| | March of Dimes Prize in Developmental Biology: Previous Recipients - Previous Recipients - March of Dimes |
| | Distinguished Lecture Series - Program in Genetics and Genomics |
| | 'Nobel laureate is my lost sibling' - News - A Step Beyond: 'Nobel laureate is my lost sibling' |
| | Reunion beckons for Nobel winner and his long lost step-sister - Reunion beckons for Nobel winner and his long lost step-sister - Science, News - The Independent |
| | Nobel Winner Reunited With Sister Lost in WWII - ABC News - ABC News |
| | Mario Capecchi Nobel Prize lecture - Mario R. Capecchi - Nobel Lecture |
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