He was a fullback on the Ohio State University football team from 1924 through 1926. In 1926 he was team captain and led the team to a 7-1 record. After the season he was named to several All America teams.
After college he became a backup infielder in Major League Baseball who played in six games for the Boston Red Sox in the 1927 season. A native of Braddock, Pennsylvania, he batted and threw right-handed.
Karow hit .200, going two for 10 with one double.
Following his playing career, Karow served as a coach in the United States Naval Academy (1936). He later coached for the Texas A&M University (1938–1941, 1948–1950) and Ohio State University teams, leading the Buckeyes to the College World Series four times (1951, 1965–1967), including the 1966 Championship Title. He also served in the military during World War II.
Karow died in Bryan, Texas at age 81.