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Mebendazole: Wikis


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Systematic (IUPAC) name
methyl (5-benzoyl-1H-benzimidazol-2-yl)carbamate
CAS number 31431-39-7
ATC code P02CA01 QP52AC09
PubChem 4030
DrugBank APRD01086
ChemSpider 3890
Chemical data
Formula C16H13N3O3 
Mol. mass 295.293 g/mol
SMILES eMolecules & PubChem
Physical data
Melt. point 288.5 °C (551 °F)
Pharmacokinetic data
Bioavailability  ?
Metabolism Hepatic
Half life 2.5 to 5.5 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat. C
Legal status  ?
Routes Oral
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Mebendazole or MBZ, marketed as Ovex, Vermox, Antiox, Pripsen, is a benzimidazole drug that is used to treat infestations by worms including pinworms, roundworms, tapeworms, hookworms, and whipworms.



Mebendazole is thought to cause slow immobilization and death of the worms by selectively inhibiting the synthesis of microtubules.


Oral dosage for treatment of pinworms is 100 mg per dose, with one dose taken every two weeks.[citation needed] This regime is repeated two weeks later if the infection has not cleared up. The dosage may differ depending on which type of worm someone is infected with. Some available products deliver 500 mg in a single dose, effectively eliminating the intestinal worms. Dosage on the packaging of some products suggests that 100 mg is a suitable single dose tablet. However using this minimal dose may be ineffective.[citation needed]

Drug interactions

Carbamazepine and phenytoin lower serum levels of mebendazole. Cimetidine raises serum mebendazole levels, increasing its effectiveness.[1]

Stevens-Johnson syndrome (toxic epidermal necrolysis) when mebendazole is combined with high doses of metronidazole.[2]

See also

External links

  • Vermox (UK manufacturer's website)


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