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Medifoxamine: Wikis

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1 : 1 mixture (racemate)
Systematic (IUPAC) name
(RS)-N,N-dimethyl-2,2-diphenoxyethanamine
Identifiers
CAS number 32359-34-5
ATC code N06AX13
PubChem 36109
Chemical data
Formula C 16H19NO2  
Mol. mass 257.328 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Medifoxamine (Cledial) is an antidepressant drug which acts as a dopamine reuptake inhibitor[1] and acts as an agonist at the 5HT2A and 5HT2C receptors.[2] It was used mainly in France,[3] but was withdrawn following problems with hepatotoxicity.[4]

References

  1. ^ Saleh S, Turner P. Ocular hypotensive effects of medifoxamine. British Journal of Clinical Pharmacology. 1992 Sep;34(3):269-71. PMID 1389953
  2. ^ Martin P, Lemonnier F. The role of type 2 serotonin receptors, 5-HT2A and 5-HT2C, in depressive disorders: effect of medifoxamine. (French) L'Encéphale. 1994 Jul-Aug;20(4):427-35. PMID 7988407
  3. ^ Mitchell PB. Novel French antidepressants not available in the United States. Psychopharmacology Bulletin. 1995;31(3):509-19. PMID 8668756
  4. ^ Dumortier G, Cabaret W, Stamatiadis L, Saba G, Benadhira R, Rocamora JF, Aubriot-Delmas B, Glikman J, Januel D. Hepatic tolerance of atypical antipsychotic drugs. (French). L'Encéphale. 2002 Nov-Dec;28(6 Pt 1):542-51. PMID 12506267
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