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Melanin-concentrating hormone receptor 2
Identifiers
Symbols MCHR2; MCH2; GPR145; MCH2R; SLT
External IDs OMIM606111 HomoloGene50004 IUPHAR: MCH2 GeneCards: MCHR2 Gene
Orthologs
Species Human Mouse
Entrez 84539 n/a
Ensembl ENSG00000152034 n/a
UniProt Q969V1 n/a
RefSeq (mRNA) NM_001040179 n/a
RefSeq (protein) NP_001035269 n/a
Location (UCSC) Chr 6:
100.47 - 100.55 Mb
n/a
PubMed search [1] n/a

Melanin-concentrating hormone receptor 2, also known as MCH2, is both a human gene, and the receptor that it codes for.[1] MCH2 is found in humans, dogs, ferrets, and some other primates and carnivores, but is not found in mice or rats. This has delayed research into the receptor as a therapeutic target, due to most early pharmaceutical research usually being conducted in small mammals such as mice, rats or rabbits which lack the MCH2 gene and its receptor product.

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Further reading

  • Hill J, Duckworth M, Murdock P, et al. (2001). "Molecular cloning and functional characterization of MCH2, a novel human MCH receptor.". J. Biol. Chem. 276 (23): 20125–9. doi:10.1074/jbc.M102068200. PMID 11274220.  
  • Mori M, Harada M, Terao Y, et al. (2001). "Cloning of a novel G protein-coupled receptor, SLT, a subtype of the melanin-concentrating hormone receptor.". Biochem. Biophys. Res. Commun. 283 (5): 1013–8. doi:10.1006/bbrc.2001.4893. PMID 11355873.  
  • Sailer AW, Sano H, Zeng Z, et al. (2001). "Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R.". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7564–9. doi:10.1073/pnas.121170598. PMID 11404457.  
  • An S, Cutler G, Zhao JJ, et al. (2001). "Identification and characterization of a melanin-concentrating hormone receptor.". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7576–81. doi:10.1073/pnas.131200698. PMID 11416225.  
  • Wang S, Behan J, O'Neill K, et al. (2001). "Identification and pharmacological characterization of a novel human melanin-concentrating hormone receptor, mch-r2.". J. Biol. Chem. 276 (37): 34664–70. doi:10.1074/jbc.M102601200. PMID 11459838.  
  • Bednarek MA, Feighner SD, Hreniuk DL, et al. (2001). "Short segment of human melanin-concentrating hormone that is sufficient for full activation of human melanin-concentrating hormone receptors 1 and 2.". Biochemistry 40 (31): 9379–86. doi:10.1021/bi010867p. PMID 11478907.  
  • Bednarek MA, Tan C, Hreniuk DL, et al. (2002). "Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1.". J. Biol. Chem. 277 (16): 13821–6. doi:10.1074/jbc.M200563200. PMID 11839762.  
  • Audinot V, Lahaye C, Suply T, et al. (2002). "SVK14 cells express an MCH binding site different from the MCH1 or MCH2 receptor.". Biochem. Biophys. Res. Commun. 295 (4): 841–8. doi:10.1016/S0006-291X(02)00763-5. PMID 12127971.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Logan DW, Bryson-Richardson RJ, Pagán KE, et al. (2003). "The structure and evolution of the melanocortin and MCH receptors in fish and mammals.". Genomics 81 (2): 184–91. doi:10.1016/S0888-7543(02)00037-X. PMID 12620396.  
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Vitale RM, Pedone C, De Benedetti PG, Fanelli F (2004). "Structural features of the inactive and active states of the melanin-concentrating hormone receptors: insights from molecular simulations.". Proteins 56 (3): 430–48. doi:10.1002/prot.20125. PMID 15229878.  
  • Hawes BE, Green B, O'Neill K, et al. (2004). "Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2.". Obes. Res. 12 (8): 1327–34. doi:10.1038/oby.2004.167. PMID 15340116.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
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