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Melanin-concentrating hormone receptor 2
Symbols MCHR2; MCH2; GPR145; MCH2R; SLT
External IDs OMIM606111 HomoloGene50004 IUPHAR: MCH2 GeneCards: MCHR2 Gene
Species Human Mouse
Entrez 84539 n/a
Ensembl ENSG00000152034 n/a
UniProt Q969V1 n/a
RefSeq (mRNA) NM_001040179 n/a
RefSeq (protein) NP_001035269 n/a
Location (UCSC) Chr 6:
100.47 - 100.55 Mb
PubMed search [1] n/a

Melanin-concentrating hormone receptor 2, also known as MCH2, is both a human gene, and the receptor that it codes for.[1] MCH2 is found in humans, dogs, ferrets, and some other primates and carnivores, but is not found in mice or rats. This has delayed research into the receptor as a therapeutic target, due to most early pharmaceutical research usually being conducted in small mammals such as mice, rats or rabbits which lack the MCH2 gene and its receptor product.


See also


External links

Further reading

  • Hill J, Duckworth M, Murdock P, et al. (2001). "Molecular cloning and functional characterization of MCH2, a novel human MCH receptor.". J. Biol. Chem. 276 (23): 20125–9. doi:10.1074/jbc.M102068200. PMID 11274220.  
  • Mori M, Harada M, Terao Y, et al. (2001). "Cloning of a novel G protein-coupled receptor, SLT, a subtype of the melanin-concentrating hormone receptor.". Biochem. Biophys. Res. Commun. 283 (5): 1013–8. doi:10.1006/bbrc.2001.4893. PMID 11355873.  
  • Sailer AW, Sano H, Zeng Z, et al. (2001). "Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R.". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7564–9. doi:10.1073/pnas.121170598. PMID 11404457.  
  • An S, Cutler G, Zhao JJ, et al. (2001). "Identification and characterization of a melanin-concentrating hormone receptor.". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7576–81. doi:10.1073/pnas.131200698. PMID 11416225.  
  • Wang S, Behan J, O'Neill K, et al. (2001). "Identification and pharmacological characterization of a novel human melanin-concentrating hormone receptor, mch-r2.". J. Biol. Chem. 276 (37): 34664–70. doi:10.1074/jbc.M102601200. PMID 11459838.  
  • Bednarek MA, Feighner SD, Hreniuk DL, et al. (2001). "Short segment of human melanin-concentrating hormone that is sufficient for full activation of human melanin-concentrating hormone receptors 1 and 2.". Biochemistry 40 (31): 9379–86. doi:10.1021/bi010867p. PMID 11478907.  
  • Bednarek MA, Tan C, Hreniuk DL, et al. (2002). "Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1.". J. Biol. Chem. 277 (16): 13821–6. doi:10.1074/jbc.M200563200. PMID 11839762.  
  • Audinot V, Lahaye C, Suply T, et al. (2002). "SVK14 cells express an MCH binding site different from the MCH1 or MCH2 receptor.". Biochem. Biophys. Res. Commun. 295 (4): 841–8. doi:10.1016/S0006-291X(02)00763-5. PMID 12127971.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Logan DW, Bryson-Richardson RJ, Pagán KE, et al. (2003). "The structure and evolution of the melanocortin and MCH receptors in fish and mammals.". Genomics 81 (2): 184–91. doi:10.1016/S0888-7543(02)00037-X. PMID 12620396.  
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Vitale RM, Pedone C, De Benedetti PG, Fanelli F (2004). "Structural features of the inactive and active states of the melanin-concentrating hormone receptors: insights from molecular simulations.". Proteins 56 (3): 430–48. doi:10.1002/prot.20125. PMID 15229878.  
  • Hawes BE, Green B, O'Neill K, et al. (2004). "Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2.". Obes. Res. 12 (8): 1327–34. doi:10.1038/oby.2004.167. PMID 15340116.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  


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