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Melanocortin 5 receptor: Wikis

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Melanocortin 5 receptor
Identifiers
Symbols MC5R;
External IDs OMIM600042 MGI99420 HomoloGene4321 IUPHAR: MC5 GeneCards: MC5R Gene
RNA expression pattern
PBB GE MC5R 208565 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4161 17203
Ensembl ENSG00000176136 ENSMUSG00000007480
UniProt P33032 Q496T0
RefSeq (mRNA) NM_005913 NM_013596
RefSeq (protein) NP_005904 NP_038624
Location (UCSC) Chr 18:
13.82 - 13.82 Mb
Chr 18:
68.46 - 68.47 Mb
PubMed search [1] [2]

Melanocortin receptor 5 is a protein that in humans is encoded by the MC5R gene.[1][2] It is located on the chromosome 18 in the human genome.[2] When the melanocortin 5 receptor was disrupted in transgenic mice, it induced disruption of their exocrine glands and resulted in decreased production of sebum.[3]

Contents

See also

References

  1. ^ Chhajlani V, Muceniece R, Wikberg JE (Oct 1993). "Molecular cloning of a novel human melanocortin receptor". Biochem Biophys Res Commun 195 (2): 866-73. doi:10.1006/bbrc.1993.2125. PMID 8396929.  
  2. ^ a b "Entrez Gene: MC5R melanocortin 5 receptor". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4161.  
  3. ^ Thiboutot, Diane; Sivarajah, Aruntha; Gilliland, Kathryn ; Cong, Zhaoyuan; Clawson, Gary (2000). "The Melanocortin 5 Receptor is Expressed in Human Sebaceous Glands and Rat Preputial Cells". Journal of Investigative Dermatology 115: 614–619. doi:10.1046/j.1523-1747.2000.00094.x. http://www.nature.com/jid/journal/v115/n4/abs/5600836a.html. Retrieved 2008-01-04.  

External links

Further reading

  • Fathi Z, Iben LG, Parker EM (1995). "Cloning, expression, and tissue distribution of a fifth melanocortin receptor subtype.". Neurochem. Res. 20 (1): 107–13. doi:10.1007/BF00995160. PMID 7739752.  
  • Chowdhary BP, Gustavsson I, Wikberg JE, Chhajlani V (1994). "Localization of the human melanocortin-5 receptor gene (MC5R) to chromosome band 18p11.2 by fluorescence in situ hybridization.". Cytogenet. Cell Genet. 68 (1-2): 79–81. doi:10.1159/000133895. PMID 7956366.  
  • Griffon N, Mignon V, Facchinetti P, et al. (1994). "Molecular cloning and characterization of the rat fifth melanocortin receptor.". Biochem. Biophys. Res. Commun. 200 (2): 1007–14. doi:10.1006/bbrc.1994.1550. PMID 8179577.  
  • Gantz I, Shimoto Y, Konda Y, et al. (1994). "Molecular cloning, expression, and characterization of a fifth melanocortin receptor.". Biochem. Biophys. Res. Commun. 200 (3): 1214–20. doi:10.1006/bbrc.1994.1580. PMID 8185570.  
  • Chhajlani V (1997). "Distribution of cDNA for melanocortin receptor subtypes in human tissues.". Biochem. Mol. Biol. Int. 38 (1): 73–80. PMID 8932521.  
  • Yang YK, Ollmann MM, Wilson BD, et al. (1997). "Effects of recombinant agouti-signaling protein on melanocortin action.". Mol. Endocrinol. 11 (3): 274–80. doi:10.1210/me.11.3.274. PMID 9058374.  
  • Frändberg PA, Xu X, Chhajlani V (1997). "Glutamine235 and arginine272 in human melanocortin 5 receptor determines its low affinity to MSH.". Biochem. Biophys. Res. Commun. 236 (2): 489–92. doi:10.1006/bbrc.1997.6994. PMID 9240466.  
  • Yang YK, Thompson DA, Dickinson CJ, et al. (1999). "Characterization of Agouti-related protein binding to melanocortin receptors.". Mol. Endocrinol. 13 (1): 148–55. doi:10.1210/me.13.1.148. PMID 9892020.  
  • Hatta N, Dixon C, Ray AJ, et al. (2001). "Expression, candidate gene, and population studies of the melanocortin 5 receptor.". J. Invest. Dermatol. 116 (4): 564–70. doi:10.1046/j.0022-202x.2001.01286.x. PMID 11286624.  
  • Bednarek MA, MacNeil T, Kalyani RN, et al. (2001). "Selective, high affinity peptide antagonists of alpha-melanotropin action at human melanocortin receptor 4: their synthesis and biological evaluation in vitro.". J. Med. Chem. 44 (22): 3665–72. doi:10.1021/jm010165y. PMID 11606131.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Lapinsh M, Veiksina S, Uhlén S, et al. (2005). "Proteochemometric mapping of the interaction of organic compounds with melanocortin receptor subtypes.". Mol. Pharmacol. 67 (1): 50–9. doi:10.1124/mol.104.002857. PMID 15470082.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Lohoff FW, Berrettini WH (2006). "Lack of association between variations in the melanocortin 5 receptor gene and bipolar disorder.". Psychiatr. Genet. 15 (4): 255–8. doi:10.1097/00041444-200512000-00007. PMID 16314755.  
  • Grieco P, Cai M, Han G, et al. (2007). "Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5.". Peptides 28 (6): 1191–6. doi:10.1016/j.peptides.2007.02.012. PMID 17482720.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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