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Melanocortin 5 receptor: Wikis


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Melanocortin 5 receptor
Symbols MC5R;
External IDs OMIM600042 MGI99420 HomoloGene4321 IUPHAR: MC5 GeneCards: MC5R Gene
RNA expression pattern
PBB GE MC5R 208565 at tn.png
More reference expression data
Species Human Mouse
Entrez 4161 17203
Ensembl ENSG00000176136 ENSMUSG00000007480
UniProt P33032 Q496T0
RefSeq (mRNA) NM_005913 NM_013596
RefSeq (protein) NP_005904 NP_038624
Location (UCSC) Chr 18:
13.82 - 13.82 Mb
Chr 18:
68.46 - 68.47 Mb
PubMed search [1] [2]

Melanocortin receptor 5 is a protein that in humans is encoded by the MC5R gene.[1][2] It is located on the chromosome 18 in the human genome.[2] When the melanocortin 5 receptor was disrupted in transgenic mice, it induced disruption of their exocrine glands and resulted in decreased production of sebum.[3]


See also


  1. ^ Chhajlani V, Muceniece R, Wikberg JE (Oct 1993). "Molecular cloning of a novel human melanocortin receptor". Biochem Biophys Res Commun 195 (2): 866-73. doi:10.1006/bbrc.1993.2125. PMID 8396929.  
  2. ^ a b "Entrez Gene: MC5R melanocortin 5 receptor".  
  3. ^ Thiboutot, Diane; Sivarajah, Aruntha; Gilliland, Kathryn ; Cong, Zhaoyuan; Clawson, Gary (2000). "The Melanocortin 5 Receptor is Expressed in Human Sebaceous Glands and Rat Preputial Cells". Journal of Investigative Dermatology 115: 614–619. doi:10.1046/j.1523-1747.2000.00094.x. Retrieved 2008-01-04.  

External links

Further reading

  • Fathi Z, Iben LG, Parker EM (1995). "Cloning, expression, and tissue distribution of a fifth melanocortin receptor subtype.". Neurochem. Res. 20 (1): 107–13. doi:10.1007/BF00995160. PMID 7739752.  
  • Chowdhary BP, Gustavsson I, Wikberg JE, Chhajlani V (1994). "Localization of the human melanocortin-5 receptor gene (MC5R) to chromosome band 18p11.2 by fluorescence in situ hybridization.". Cytogenet. Cell Genet. 68 (1-2): 79–81. doi:10.1159/000133895. PMID 7956366.  
  • Griffon N, Mignon V, Facchinetti P, et al. (1994). "Molecular cloning and characterization of the rat fifth melanocortin receptor.". Biochem. Biophys. Res. Commun. 200 (2): 1007–14. doi:10.1006/bbrc.1994.1550. PMID 8179577.  
  • Gantz I, Shimoto Y, Konda Y, et al. (1994). "Molecular cloning, expression, and characterization of a fifth melanocortin receptor.". Biochem. Biophys. Res. Commun. 200 (3): 1214–20. doi:10.1006/bbrc.1994.1580. PMID 8185570.  
  • Chhajlani V (1997). "Distribution of cDNA for melanocortin receptor subtypes in human tissues.". Biochem. Mol. Biol. Int. 38 (1): 73–80. PMID 8932521.  
  • Yang YK, Ollmann MM, Wilson BD, et al. (1997). "Effects of recombinant agouti-signaling protein on melanocortin action.". Mol. Endocrinol. 11 (3): 274–80. doi:10.1210/me.11.3.274. PMID 9058374.  
  • Frändberg PA, Xu X, Chhajlani V (1997). "Glutamine235 and arginine272 in human melanocortin 5 receptor determines its low affinity to MSH.". Biochem. Biophys. Res. Commun. 236 (2): 489–92. doi:10.1006/bbrc.1997.6994. PMID 9240466.  
  • Yang YK, Thompson DA, Dickinson CJ, et al. (1999). "Characterization of Agouti-related protein binding to melanocortin receptors.". Mol. Endocrinol. 13 (1): 148–55. doi:10.1210/me.13.1.148. PMID 9892020.  
  • Hatta N, Dixon C, Ray AJ, et al. (2001). "Expression, candidate gene, and population studies of the melanocortin 5 receptor.". J. Invest. Dermatol. 116 (4): 564–70. doi:10.1046/j.0022-202x.2001.01286.x. PMID 11286624.  
  • Bednarek MA, MacNeil T, Kalyani RN, et al. (2001). "Selective, high affinity peptide antagonists of alpha-melanotropin action at human melanocortin receptor 4: their synthesis and biological evaluation in vitro.". J. Med. Chem. 44 (22): 3665–72. doi:10.1021/jm010165y. PMID 11606131.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Lapinsh M, Veiksina S, Uhlén S, et al. (2005). "Proteochemometric mapping of the interaction of organic compounds with melanocortin receptor subtypes.". Mol. Pharmacol. 67 (1): 50–9. doi:10.1124/mol.104.002857. PMID 15470082.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Lohoff FW, Berrettini WH (2006). "Lack of association between variations in the melanocortin 5 receptor gene and bipolar disorder.". Psychiatr. Genet. 15 (4): 255–8. doi:10.1097/00041444-200512000-00007. PMID 16314755.  
  • Grieco P, Cai M, Han G, et al. (2007). "Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5.". Peptides 28 (6): 1191–6. doi:10.1016/j.peptides.2007.02.012. PMID 17482720.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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