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Meptazinol
Systematic (IUPAC) name
(RS)-3-(3-ethyl-1-methylazepan-3-yl)phenol
Identifiers
CAS number 54340-58-8
ATC code N02AX05
PubChem 41049
Chemical data
Formula C 15H23NO 
Mol. mass 233.34922 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism The peak analgesic effect is seen within 30–60 minutes and lasts about 3–4 hours.
Half life Half-Life (1.4–4 hours).
Excretion The drug is rapidly metabolised to the glucuronide, and mostly excreted in the urine.
Therapeutic considerations
Pregnancy cat.  ?
Legal status POM (UK)
Dependence Liability Low
Routes Oral, IM, IV

Meptazinol (trade name Meptid) is an opioid analgesic for use with moderate to severe pain, most commonly used to treat pain in obstetrics (childbirth). A partial µ-opioid receptor agonist, its mixed agonist/antagonist activity affords it a lower risk of dependence and abuse than full µ agonists like morphine. Meptazinol exhibits not only a short onset of action, but also a shorter duration of action relative to other opioids such as morphine, pentazocine, or buprenorphine.[1]

References

  1. ^ Holmes B, Ward A. "Meptazinol. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy." Drugs. 1985 Oct; 30(4):285-312. PMID 2998723

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