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Systematic (IUPAC) name
10-(4-azabicyclo[2.2.2] oct-7-ylmethyl) phenothiazine
CAS number 29216-28-2
ATC code R06AD07
PubChem 4066
DrugBank APRD00386
Chemical data
Formula C 20H22N2S 
Mol. mass 322.468 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
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Mequitazine (Primalan) is an antihistamine and anticholinergic of the phenothiazine chemical class. It is used to treat allergies and rhinitis.

See also


  • Ramírez Chanona N, del Rio Navarro B, Pérez Martín J. "Efficacy of mequitazine (Primalan) on the relief of symptoms of allergic rhinoconjunctivitis in children. Documented clinical experience". Rev Alerg Mex 52 (6): 221–5. PMID 16568706.  
  • Theunissen E, Vermeeren A, van Oers A, van Maris I, Ramaekers J (2004). "A dose-ranging study of the effects of mequitazine on actual driving, memory and psychomotor performance as compared to dexchlorpheniramine, cetirizine and placebo.". Clin Exp Allergy 34 (2): 250–8. doi:10.1111/j.1365-2222.2004.01874.x. PMID 14987305.  
  • Nakamura K, Yokoi T, Kodama T, Inoue K, Nagashima K, Shimada N, Shimizu T, Kamataki T (1998). "Oxidation of histamine H1 antagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes.". J Pharmacol Exp Ther 284 (2): 437–42. PMID 9454781.  
  • Persi L, Dupin O, Arnaud B, Trinquand C, Michel F, Bousquet J (1997). "Efficacy of mequitazine in comparison with placebo assessed by ocular challenge with allergen in allergic conjunctivitis.". Allergy 52 (4): 451–4. doi:10.1111/j.1398-9995.1997.tb01028.x. PMID 9188930.  


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