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Mesembrine
Mesembrine.svg
Mesembrine3d.png
IUPAC name
Identifiers
CAS number 468-53-1
PubChem 193296
SMILES
Properties
Molecular formula C17H23NO3
Molar mass 289.37 g mol−1
log P 1.1
Supplementary data page
Structure and
properties
n, εr, etc.
Thermodynamic
data
Phase behaviour
Solid, liquid, gas
Spectral data UV, IR, NMR, MS
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Mesembrine is an alkaloid present in Sceletium tortuosum.[1] One patent claims that mesembrine is a serotonin reuptake inhibitor [2], although there is currently no peer reviewed scientific literature to confirm this claim. It has also been shown to be a PDE4 inhibitor.[3] Mesembrine may contribute to the antidepressant effects of kanna.

References

  1. ^ Smith M, Crouch N, Gericke N, Hirst M (1996). "Psychoactive constituents of the genus Sceletium N.E.Br. and other Mesembryanthemaceae: a review". J Ethnopharmacol 50 (3): 119–30. doi:10.1016/0378-8741(95)01342-3. PMID 8691846.  
  2. ^ Pharmaceutical compositions containing mesembrine and related compounds. U.S. Patent 6,288,104 (PDF)
  3. ^ Mesembrine - an inhibitor of PDE4 that follows structure-activity relationship to rolipram. [1]
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