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Mesoridazine
Systematic (IUPAC) name
10-{2-[(RS)1-Methylpiperidin-2-yl]ethyl}- 2-methylsulfinyl- 10H-phenothiazine
Identifiers
CAS number 5588-33-0
ATC code N05AC03
PubChem 4078
DrugBank APRD00610
Chemical data
Formula C 21H26N2OS2  
Mol. mass 386.576 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 4%
Metabolism Hepatic/Renal
Half life 24 to 48 hours
Excretion Biliary and renal
Therapeutic considerations
Pregnancy cat. C(US)
Legal status Prescription only
Routes oral, intravenous
 Yes check.svgY(what is this?)  (verify)

Mesoridazine (Serentil) is a piperidine neuroleptic drug belonging to the class of drugs called phenothiazines, used in the treatment of schizophrenia. It is a metabolite of thioridazine. The name is partially derived from the MEthyl-SulfOxy group in the structure.

It has central antiadrenergic, antidopaminergic, antiserotonergic and weak muscarinic anticholinergic effects.

Serious side effects include akathisia, tardive dyskinesia and the potentially fatal neuroleptic malignant syndrome.

Mesoridazine was withdrawn from the United States market in 2004 due to dangerous side effects, namely irregular heart beat and QT-prolongation of the electrocardiogram.[1]

References

  1. ^ [1]







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