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Metabotropic glutamate receptor 6: Wikis

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Glutamate receptor, metabotropic 6
Identifiers
Symbols GRM6; CSNB1B; DKFZp686H1993; GPRC1F; MGLUR6; mGlu6
External IDs OMIM604096 HomoloGene20232 IUPHAR: mGlu6 GeneCards: GRM6 Gene
RNA expression pattern
PBB GE GRM6 208035 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2916 n/a
Ensembl ENSG00000113262 n/a
UniProt O15303 n/a
RefSeq (mRNA) NM_000843 n/a
RefSeq (protein) NP_000834 n/a
Location (UCSC) Chr 5:
178.32 - 178.35 Mb
n/a
PubMed search [1] n/a

Glutamate receptor, metabotropic 6, also known as GRM6, is a protein which in humans is encoded by the GRM6 gene.[1][2]

Contents

Function

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.[1]

See also

References

  1. ^ a b "Entrez Gene: GRM6 glutamate receptor, metabotropic 6". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2916.  
  2. ^ Hashimoto T, Inazawa J, Okamoto N, Tagawa Y, Bessho Y, Honda Y, Nakanishi S (June 1997). "The whole nucleotide sequence and chromosomal localization of the gene for human metabotropic glutamate receptor subtype 6". Eur. J. Neurosci. 9 (6): 1226–35. doi:10.1111/j.1460-9568.1997.tb01477.x. PMID 9215706.  

External links

Further reading

  • Hashimoto T, Inazawa J, Okamoto N, et al. (1997). "The whole nucleotide sequence and chromosomal localization of the gene for human metabotropic glutamate receptor subtype 6.". Eur. J. Neurosci. 9 (6): 1226–35. doi:10.1111/j.1460-9568.1997.tb01477.x. PMID 9215706.  
  • Dhingra A, Lyubarsky A, Jiang M, et al. (2001). "The light response of ON bipolar neurons requires G[alpha]o.". J. Neurosci. 20 (24): 9053–8. PMID 11124982.  
  • Valerio A, Ferraboli S, Paterlini M, et al. (2001). "Identification of novel alternatively-spliced mRNA isoforms of metabotropic glutamate receptor 6 gene in rat and human retina.". Gene 262 (1-2): 99–106. doi:10.1016/S0378-1119(00)00547-3. PMID 11179672.  
  • Dryja TP, McGee TL, Berson EL, et al. (2005). "Night blindness and abnormal cone electroretinogram ON responses in patients with mutations in the GRM6 gene encoding mGluR6.". Proc. Natl. Acad. Sci. U.S.A. 102 (13): 4884–9. doi:10.1073/pnas.0501233102. PMID 15781871.  
  • Zeitz C, van Genderen M, Neidhardt J, et al. (2005). "Mutations in GRM6 cause autosomal recessive congenital stationary night blindness with a distinctive scotopic 15-Hz flicker electroretinogram.". Invest. Ophthalmol. Vis. Sci. 46 (11): 4328–35. doi:10.1167/iovs.05-0526. PMID 16249515.  
  • Zeitz C, Forster U, Neidhardt J, et al. (2007). "Night blindness-associated mutations in the ligand-binding, cysteine-rich, and intracellular domains of the metabotropic glutamate receptor 6 abolish protein trafficking.". Hum. Mutat. 28 (8): 771–80. doi:10.1002/humu.20499. PMID 17405131.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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